A5002555523- Protein Hydrolysis and Bioactive Peptides
- Advanced Glycation End Products research
- interferon and immune responses
- Proteins in Food Systems
- Signaling Pathways in Disease
- Fungal Biology and Applications
- Polysaccharides and Plant Cell Walls
- Phytochemicals and Antioxidant Activities
- Biochemical effects in animals
- Seaweed-derived Bioactive Compounds
- SARS-CoV-2 and COVID-19 Research
- Meat and Animal Product Quality
- Phytoestrogen effects and research
- Galectins and Cancer Biology
- Animal Nutrition and Physiology
- Parasites and Host Interactions
- Cytokine Signaling Pathways and Interactions
- Animal Virus Infections Studies
- Heat shock proteins research
- Viral Infections and Vectors
- Phagocytosis and Immune Regulation
- Drug-Induced Ocular Toxicity
- Protein Interaction Studies and Fluorescence Analysis
- Mosquito-borne diseases and control
- Medicinal Plants and Bioactive Compounds
Second Affiliated Hospital of Zhejiang University
2024
Institute of High Energy Physics
2024
Chinese Academy of Sciences
2024
Henan Agricultural University
2020-2023
Tianjin University of Science and Technology
2020-2022
State Key Laboratory of Food Science and Technology
2020-2022
Jiangnan University
2020-2022
Binzhou University
2016-2022
Binzhou Medical University
2016-2022
Ministry of Education of the People's Republic of China
2018
Abstract The excessive and inappropriate production of reactive oxygen species (ROS) can cause oxidative stress is implicated in the pathogenesis lung cancer. Cyclophilin A (CypA), a member immunophilin family, secreted response to ROS. To determine role CypA injury, we investigated that plays human carcinoma (A549) cells. Here, showed protective effect recombinant (hCypA) on hydrogen peroxide (H2O2)-induced damage A549 cells, which play crucial roles Our results demonstrated hCypA...
The interaction of soy protein isolate (SPI) and its hydrolysates (SPIHs) with cyanidin-3-O-glucoside (C3G) at pH 7.0 were investigated to clarify the changes in antioxidant capacity their complexes. results intrinsic fluorescence revealed that C3G binds SPI/SPIHs mainly through hydrophobic interaction, binding affinity SPI was stronger than SPIHs. Circular dichroism Fourier-transform infrared spectroscopy analyses did not significantly change secondary structures SPI/SPIHs, while surface...
Abstract In the present study, a novel cold water‐soluble polysaccharide fraction (LGP) with average molecular weight of 1.78×10 6 Da was extracted and purified from Leucopaxillus giganteus its primary structure as well in vivo antitumor activity evaluated. The monosaccharide composition LGP determined by ion chromatography to be galactose, xylose, glucose fucose molar ratio 2.568 : 1.209 1 0.853. Its backbone composed α‐D‐Glu, α‐D‐Xyl, α‐D‐Gal α‐L‐Fuc. results experiment demonstrated that...
Numerous polysaccharides isolated from plants have been used to augment traditional drugs in the treatment of cancer. In order explore influence hepatocellular carcinoma, a novel cold water-soluble polysaccharide was separated Rhodiola rosea L. root (RLP) and then its structure anti-cancer activities were tested. The chemical compositions high performance gel permeation chromatography (HPGPC) results indicated that RLP an acid heteropolysaccharide with molecular weight about 1.15×106 Da....
Cyclophilin A (CypA, also known as PPIA) is an essential member of the immunophilin family. As intracellular target immunosuppressive drug cyclosporin (CsA) or a peptidyl-prolyl cis/trans isomerase (PPIase), it catalyzes cis-trans isomerization proline amidic peptide bonds, through which regulates variety biological processes, such signaling, transcription and apoptosis. In this study, we found that CypA enhanced Twist1 phosphorylation at Ser68 inhibited apoptosis in A549 cells....
In this study, the Tianjin and Baiyangdian duck eggs were used to pickle preserved by a novel technology—vacuum technology. The curing time of vacuum technology was reduced three times compared with traditional method. weight gain rates pickled method first increased then decreased, while weightless at day. With prolonging time, pH egg yolks showed rising trend, no matter or cholesterol contents 16.22% 29.59% eggs. Besides, there 15 kinds fatty acid detected in SEM images that eggshells...
Abstract Background Cytosolic RNA sensing can elicit immune responses against viral pathogens. However, antiviral must be tightly regulated to avoid the uncontrolled production of type I interferons (IFN) that might have deleterious effects on host. Upon bacterial infection, germinal center kinase MST4 directly phosphorylate adaptor TRAF6 limit inflammatory responses, thereby avoiding damage caused by excessive activation. molecular mechanism how regulates virus-mediated IFN remains unknown....
Pyridaben is a broad-spectrum acaricide widely used in agriculture, accidental or self-administration of large doses pyridaben can cause multiple organ failure patients. Due to its damage organs and no specific antidote, the mortality rate high. This paper reports two patients who took amount pyridaben, developed severe metabolic acidosis, hyperlactatemia, toxic encephalopathy, liver, kidney, heart digestive tract damage. After timely gastric lavage, catharsis, support andblood purification...