A5115599138- Ocular Diseases and Behçet’s Syndrome
- Research in Cotton Cultivation
- Plant Stress Responses and Tolerance
- Invertebrate Taxonomy and Ecology
- Heavy metals in environment
- Environmental Toxicology and Ecotoxicology
- Soil Carbon and Nitrogen Dynamics
- Plant Molecular Biology Research
- Inflammasome and immune disorders
- Signaling Pathways in Disease
- Genetic and phenotypic traits in livestock
- TGF-β signaling in diseases
- Systemic Lupus Erythematosus Research
- Plant Gene Expression Analysis
- Bone Metabolism and Diseases
- Plant Reproductive Biology
- Vasculitis and related conditions
- Otitis Media and Relapsing Polychondritis
- Galectins and Cancer Biology
- Municipal Solid Waste Management
- Extracellular vesicles in disease
- Energy Efficiency and Management
- Radar Systems and Signal Processing
- Acoustic Wave Phenomena Research
- Plant nutrient uptake and metabolism
Land Consolidation and Rehabilitation Center
2022-2025
South China Agricultural University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Peking Union Medical College Hospital
2022-2025
Chinese Academy of Agricultural Sciences
2023-2025
Zhengzhou University
2018-2025
Ministry of Natural Resources
2025
Anyang Institute of Technology
2023-2025
Cotton Research Institute
2023-2024
Ministry of Agriculture and Rural Affairs
2024
Behçet’s disease (BD) is a chronic vasculitis characterized by systemic immune aberrations. However, comprehensive understanding of disturbances in BD and how they contribute to pathogenesis lacking. Here, we performed single-cell bulk RNA sequencing profile peripheral blood mononuclear cells (PBMCs) isolated monocytes from patients healthy donors. We observed prominent expansion transcriptional changes PBMCs patients. Deciphering the monocyte heterogeneity revealed accumulation C1q-high...
Abstract The excessive and inappropriate production of reactive oxygen species (ROS) can cause oxidative stress is implicated in the pathogenesis lung cancer. Cyclophilin A (CypA), a member immunophilin family, secreted response to ROS. To determine role CypA injury, we investigated that plays human carcinoma (A549) cells. Here, showed protective effect recombinant (hCypA) on hydrogen peroxide (H2O2)-induced damage A549 cells, which play crucial roles Our results demonstrated hCypA...
Soil calcium is a vital component in plant growth and soil health. Earthworm activities impact metal distribution speciation lot by changing pH. Nevertheless, little known about how ecological earthworm species, particularly Terra Rossa soil, affect Ca distribution. This research examined the effects of four different species (epigeic Eisenia fetida (noted as EF), endogeic Amynthas robustus AR) Pontoscolex corethrurus PC), anecic aspergillum AA)) on speciations (water-soluble (CaWs),...
Phenylalanine (Phe), an aromatic amino acid, is a key precursor of flavonoids, which are crucial for plant growth and development. Arogenate dehydratase (ADT) catalyzes the final step in Phe biosynthesis. This study identified eleven ADT genes G. hirsutum, twelve barbadense, six arboreum, raimondii. Among them, GhADT5 exhibited highest upregulation under alkali stress. Silencing using virus-induced gene silencing (VIGS) reduced cotton tolerance to also led decreased phenylalanine content,...
Immune checkpoint V-domain Ig suppressor of T-cell activation (VISTA) exhibits distinct expression patterns and non-redundant immunoregulatory mechanisms in different autoimmune diseases. This study aims to investigate the VISTA patients with uveitis experimental (EAU) mice, explore its clinical significance preliminary disease development. We found that on 12 subsets peripheral blood immune cells was lower than healthy volunteers, especially neutrophils. The neutrophil active markedly...
Farmland ecosystems, as the most active carbon pool, are integral to global climate change and cycling. Therefore, systematically studying roles of sources sinks in farmland ecosystems is essential deepening our understanding cycle meeting goals “peak emissions” “carbon neutrality” agriculture. Using Web Science database, this study reviewed 1411 articles (2002–2023) via bibliometric analysis identify key research themes, trends, future priorities address suggestions for directions ecosystem...
Abstract The VIM (belonged to E3 ubiquitin ligase) gene family is crucial for plant growth, development, and stress responses, yet their role in salt remains unclear. We analyzed phylogenetic relationships, chromosomal localization, conserved motifs, structure, cis -acting elements, expression patterns of the four cotton varieties. Our findings reveal 29, 17, 14 members Gossypium hirsutum (G.hirsutum), barbadense (G.barbadense), arboreum (G.arboreum), raimondii (G. raimondii) , respectively,...
Litter size has increased and farrowing duration also prolonged in recent years. The aim of this study was to analyze the effect litter parity on (FAR) estimate possibility selecting a short duration. We recorded 32,200 parturitions 8420 Landrace × Yorkshire sows, determined duration, size, parity, gestation length. Results showed that total number born (TNB) obeyed cubic (p = 0.0004, p 0.004) relationship while alive (NBA) dead (NBD) linear 0.0239, 0.0035) with FAR. Gestation length 0.02)...
Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one the main ingredients in cigarettes and an agonist aryl hydrocarbon receptor (AhR). Mesenchymal stem cells (MSCs) including C3H10T1/2 MEF cells, adult multipotent can be differentiated toward osteoblasts during induction osteogenic factor-bone morphogenetic protein 2(BMP2). Accumulating evidence suggests that BaP decreases bone development mammals, but further mechanisms on BMP2-induced formation...
Cysteine, an early sulfur-containing compound in plants, is of significant importance sulfur metabolism. CYS encodes cysteine synthetase that further catalyzes synthesis. In this investigation, genes, identified from genome-wide analysis Gossypium hirsutum bioinformatically, led to the discovery GhCYS2 as pivotal gene responsible for Cd2+ response. The silencing through virus-induced (VIGS) rendered plants highly susceptible stress. Silencing resulted diminished levels and glutathione while...
TNF inhibitors have been used to treat autoimmune and autoinflammatory diseases. Here we report an unexpected mechanism underlying the therapeutic effects of in Behçet's disease (BD), inflammatory disorder. Using serum metabolomics peripheral immunocyte transcriptomics, find that polymorphonuclear neutrophil (PMN) from patients with BD (BD-PMN) has dysregulated mevalonate pathway subsequently increased farnesyl pyrophosphate (FPP) levels. Mechanistically, FPP induces TRPM2-calcium signaling...
Cyclophilin A (CypA, also known as PPIA) is an essential member of the immunophilin family. As intracellular target immunosuppressive drug cyclosporin (CsA) or a peptidyl-prolyl cis/trans isomerase (PPIase), it catalyzes cis-trans isomerization proline amidic peptide bonds, through which regulates variety biological processes, such signaling, transcription and apoptosis. In this study, we found that CypA enhanced Twist1 phosphorylation at Ser68 inhibited apoptosis in A549 cells....
Identification, evolution, and expression patterns of BSK (BR signaling kinase) family genes revealed that BSKs participated in the response cotton to abiotic stress maintained growth extreme environment. The steroidal hormone brassinosteroids (BR) play important roles different plant biological processes. This study focused on which were downstream regulatory element BR, order help decipher functions from development responses stresses lean evolutionary relationship BSKs. are a class...
Yunan is a crossed lean meat pig breed in China. Backfat thickness the gold standard for carcass quality grading. However, over 14 years after registration, backfat of thickened and consistency decreased. Meanwhile, no genetic study has been ever performed on population. So, this we collected all 120 nucleus individuals recorded six traits them, carried out population structure analysis, selection signals analysis genome-wide association pigs with help their founder Duroc Chinese native...
A comprehensive understanding of the influence earthworms on growth and Pb accumulation leafy vegetables is significant for soil management human health. This study was aimed to evaluate different influences two ecological earthworm species Brassica campestris in a Pb-contaminated their relationship with physico-chemical properties. In 30-day microcosm experiment, anecic native Amynthas aspergillum epigeic Eisenia fetida were inoculated artificially contaminated at levels (i.e., 0, 100, 500,...
To investigate the potential role of shelterin dysfunction in naïve CD4+ T cells pathogenesis Behçet's disease (BD).
Abstract The VIM gene family plays a vital role in the growth, development, and stress responses of plants, while molecular mechanism genes responding to salt is remain unclear. This study analyzed phylogenetic relationships, chromosomal localization, conserved motifs, structure, cis-acting elements, expression patterns four cotton varieties. A total 29, 17, 14 members were identified Gossypium hirsutum (G.hirsutum), barbadense(G.barbadense), arboreum (G.arboreum), raimondii (G. raimondii) ,...