A5078383322- Insect Resistance and Genetics
- Entomopathogenic Microorganisms in Pest Control
- Insect and Arachnid Ecology and Behavior
- Safety Warnings and Signage
- Inflammatory Myopathies and Dermatomyositis
- Ocular Diseases and Behçet’s Syndrome
- Renin-Angiotensin System Studies
- Food Safety and Hygiene
- Telomeres, Telomerase, and Senescence
- Forest Insect Ecology and Management
- CRISPR and Genetic Engineering
- Systemic Lupus Erythematosus Research
- Cancer Research and Treatments
- Microbial Metabolic Engineering and Bioproduction
- Metabolomics and Mass Spectrometry Studies
- Nanoplatforms for cancer theranostics
- Evaluation and Optimization Models
- Hormonal Regulation and Hypertension
- Insect symbiosis and bacterial influences
- Atherosclerosis and Cardiovascular Diseases
- E-commerce and Technology Innovations
- Extracellular vesicles in disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bioinformatics and Genomic Networks
- Eosinophilic Disorders and Syndromes
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Northwest A&F University
2019-2020
Harbin Medical University
2017
China National Center for Food Safety Risk Assessment
2015
Complex diseases cannot be understood only on the basis of single gene, mRNA transcript or protein but effect their collaborations. The combination consequence in molecular level can captured by alterations metabolites. With rapidly developing biomedical instruments and analytical platforms, a large number metabolite signatures complex were identified documented literature. Biologists' hardship face this amount papers recorded metabolic experiments' results calls for an automated data...
Abstract Cellular senescence (CS), a state of permanent growth arrest, is intertwined with tumorigenesis. Due to the absence specific markers, characterizing levels and senescence-related phenotypes across cancer types remain unexplored. Here, we defined computational metrics as CS scores delineate landscape 33 29 normal tissues explored CS-associated by integrating multiplatform data from ~20 000 patients ~212 single-cell profiles. showed type-specific associations genomic immune...
Behçet’s disease (BD) is a chronic vasculitis characterized by systemic immune aberrations. However, comprehensive understanding of disturbances in BD and how they contribute to pathogenesis lacking. Here, we performed single-cell bulk RNA sequencing profile peripheral blood mononuclear cells (PBMCs) isolated monocytes from patients healthy donors. We observed prominent expansion transcriptional changes PBMCs patients. Deciphering the monocyte heterogeneity revealed accumulation C1q-high...
Abstract Background Anti‐melanoma differentiation‐associated gene 5‐positive dermatomyositis (anti‐MDA5+ DM) is a rare inflammatory autoimmune disorder often complicated by life‐threatening rapidly progressive interstitial lung disease (RP‐ILD). The underlying mechanisms driving immune dysfunction and injury, however, remain poorly understood. study aims to gain insights into the disrupted landscape in peripheral pulmonary compartments of severe anti‐MDA5+ DM explore potential therapeutic...
Objective Angiotensin Ⅱ (Ang Ⅱ)-induced vascular damage is a major risk of hypertension. However, the underlying molecular mechanism AngⅡ-induced still unclear. In this study, we explored novel associated with Ang II-induced Methods We treated 8- to 12-week-old C57BL/6J male mice saline and Ⅱ(0.72 mg/kg·d) for 28 days, respectively. Then RNA media from collected aortas was extracted transcriptome sequencing. Principal component analysis applied show clear separation different samples...
Abstract WAM‐1 is a cathelicidin antimicrobial peptide found on the Macropus eugenii (Tammar wallaby) genome. It possesses antibiotic activity against broad spectrum of bacteria and fungi. In order to investigate impact this development midgut microbial composition Plutella xylostella (DBM) larvae, was introduced into Arabidopsis thaliana using Agrobacterium‐mediated floral‐dip transformation method. expression confirmed by reverse transcriptase PCR analysis. The larval growth developmental...