A5047288770- Fluoride Effects and Removal
- Heavy Metal Exposure and Toxicity
- Neuroinflammation and Neurodegeneration Mechanisms
- Trace Elements in Health
- Bone and Dental Protein Studies
- Alzheimer's disease research and treatments
- Vitamin D Research Studies
- Autophagy in Disease and Therapy
- Aquatic Ecosystems and Phytoplankton Dynamics
- Folate and B Vitamins Research
- Air Quality and Health Impacts
- Traditional Chinese Medicine Analysis
- Health, Environment, Cognitive Aging
- Sirtuins and Resveratrol in Medicine
- Organizational Learning and Leadership
- Neurogenesis and neuroplasticity mechanisms
- Genomics, phytochemicals, and oxidative stress
- Selenium in Biological Systems
- Neurological Disease Mechanisms and Treatments
- Research in Cotton Cultivation
- Cancer, Hypoxia, and Metabolism
- Quality and Supply Management
- Plant Stress Responses and Tolerance
- Neuroscience and Neuropharmacology Research
- Dental Health and Care Utilization
Zhengzhou University
2016-2025
Chinese Academy of Agricultural Sciences
2024-2025
Anyang Institute of Technology
2025
Innovation Team (China)
2020-2024
Soochow University
2019-2023
Eighth Affiliated Hospital of Sun Yat-sen University
2023
Sun Yat-sen University
2023
Wenzhou Medical University
2022
The People's Hospital of Guangxi Zhuang Autonomous Region
2022
Duke University
2021
The beginnings of late onset Alzheimer's disease (LOAD) are still unknown; however, the progressive and latent nature neurodegeneration suggests that triggering event occurs earlier in life. Aging primates exposed to lead (Pb) as infants exhib
Pb is a potential risk factor for cognition, mainly mediated by enhanced oxidative stress. Resveratrol, natural polyphenol with crucial anti-oxidative property, recently implicated in preventing cognitive deficits normal aging and neurodegenerative disorders. Its beneficial effects have been linked to sirtuin 1(SIRT1) activation. The aim of this work investigate the possible linkage between alterations Pb-induced damage impairment prolonged treatment resveratrol. Male C57BL/6 mice were given...
Microcystin-leucine arginine (MC-LR) is a cyclic heptapeptide intracellular toxin released by cyanobacteria that exhibits strong reproductive toxicity. However, little known about its biotoxicity to the female system. The present study investigates unexplored molecular pathways which oxidative stress acts on MC-LR-induced endoplasmic reticulum (ERs) and autophagy. In study, immortalized murine ovarian granular cells (KK-1 cells) were exposed 8.5, 17, 34 μg/mL (IC50) of MC-LR with or without...
The main purpose of the current article is to introduce a framework complexity childhood obesity based on family environment. A conceptual model that quantifies relationships and interactions among parental socioeconomic status, food security level, child's intake certain aspects feeding behaviour presented using structural equation modeling (SEM) concept. Structural models are analysed in terms direct indirect connections latent measurement variables lead child weight indicator. To...
Microcystins (MCs), the secondary metabolites of blue-green algae, are a ubiquitous and major cyanotoxin contaminant. Besides hepatopancreas/liver, reproductive system is regarded as most important target organ for MCs. Although reactive oxygen species (ROS) have been implicated in MCs-induced toxicity, role MCs this pathway remains unclear. In present study, Sertoli cells were employed to investigate apoptotic death involved male toxicity microcystin-LR (MC-LR). After exposure various...
Cinobufacini is a traditional Chinese medicine used clinically that has antitumor and anti-inflammatory effects. It improves colitis outcomes in the clinical setting, but mechanism underlying its function yet to be uncovered. We investigated protective effects mechanisms of cinobufacini on using dextran sulfate sodium (DSS)-induced mouse model, mainly focusing impact macrophage polarization. Our results showed dramatically ameliorated DSS-induced mice. treatment reduced infiltration...
Lead (Pb) poses a potential environmental risk factor for cognitive dysfunction during early life and childhood. Resveratrol is considered promising antioxidant with respect to the prevention of deficits act as potent SIRT1 agonist. Herein, this study aims investigate profile neurogenesis markers following Pb exposure determine regulatory role resveratrol in process. We confirmed firstly protective effects against Pb-induced impairments hippocampal Male SD rats. caused altered expression...
Fine particulate matter (PM2.5) constitutes the most significant air pollutant that causes health risks. However, mechanism(s) underlying PM2.5-induced male reproductive injury has not been clarified. In present study we explored whether PM2.5 activated inositol-requiring enzyme 1 (IRE1)/c-Jun NH 2-terminal kinase (JNK)/autophagy-signaling pathway, and this pathway mediated in rats. We established a Sprague–Dawley rat model of (1.5 mg/kg) exposure-induced injury, observed intervention...
This study examined the neuroprotective properties of resveratrol (Res) and its target sirtuin1 (SIRT1) against lead (Pb)-mediated toxicity discovered that both treatment SIRT1 overexpression restored blocked autophagic flux as well reduced β-amyloid (Aβ) contents. Four-week-old male C57BL/6 mice were employed to consumed 0.2% Pb(Ac)2 solution or deionized water for 3 months followed by 12 Res (50 mg/kg BW) vehicle gavage. In in vitro study, SH-SY5Y cells pretreated with activator SRT1720 (2...
As an emerging pollutant in the aquatic environment, microcystin-LR (MC-LR) can enter body through multiple pathways, and then induce apoptosis gonadal damage, affecting reproductive function. Previous studies focused on male toxicity induced by MC-LR neglecting its effects females. The apoptotic signal-regulated kinase 1 (ASK1) is upstream protein of P38/JNK pathway, closely associated with organ damage. However, role ASK1 MC-LR-induced unclear. Therefore, this study investigated mouse...
<title>Abstract</title> Esophageal cancer is a common malignant tumor of the digestive system, squamous cell carcinoma (ESCC) major histological subtype esophageal cancer. Multiple epidemiological evidence shows that consumption hot temperature food and beverages an important risk factor for developing ESCC, however, it underlying mechanism remains unclear. Herein, first time, we constructed animal model precancerous lesions induced by heat stimulation in rats simulated human habit eating...
Phenylalanine (Phe), an aromatic amino acid, is a key precursor of flavonoids, which are crucial for plant growth and development. Arogenate dehydratase (ADT) catalyzes the final step in Phe biosynthesis. This study identified eleven ADT genes G. hirsutum, twelve barbadense, six arboreum, raimondii. Among them, GhADT5 exhibited highest upregulation under alkali stress. Silencing using virus-induced gene silencing (VIGS) reduced cotton tolerance to also led decreased phenylalanine content,...