A5101876440- Plant Virus Research Studies
- Plant and Fungal Interactions Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Traditional Chinese Medicine Analysis
- Plant Disease Resistance and Genetics
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- Peroxisome Proliferator-Activated Receptors
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- TGF-β signaling in diseases
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Pharmacological Effects of Natural Compounds
- Biochemical Acid Research Studies
- Phytochemistry and Biological Activities
- Microbial Natural Products and Biosynthesis
- Medicinal Plant Pharmacodynamics Research
- Protein Kinase Regulation and GTPase Signaling
- Cocoa and Sweet Potato Agronomy
- Transgenic Plants and Applications
- Angiogenesis and VEGF in Cancer
- Biochemical and Molecular Research
- Kruppel-like factors research
University of Michigan
2025
Harbin Institute of Technology
2025
Dalian Medical University
2009-2023
Hainan University
2023
Soochow University
2013-2022
Harbin University of Commerce
2007-2022
MRC Laboratory of Molecular Biology
2013
Shihezi University
2009-2012
Fudan University
2010
Huashan Hospital
2010
Abstract Accumulating evidence indicates that heat shock protein (HSP) 60 is strongly associated with the pathology of atherosclerosis (AS). However, precise mechanisms by which HSP60 promotes remain unclear. In present study, we found mRNA and expression levels in thoracic aorta are enhanced not only a mouse model AS but also high-fat diet (HFD) mice. secretion was activated platelet-derived growth factor-BB (PDGF-BB) interleukin (IL)-8 both human umbilical vein endothelial cells (HUVECs)...
To identify the interaction between known regulators of atherosclerosis, microRNA-92a (miR-92a), Rho-associated coiled-coil-forming kinase (ROCK) and myosin light chain (MLCK), we examined their expressions during proliferation migration platelet-derived growth factor-BB (PDGF-BB)-regulated vascular smooth muscle cells (VSMCs), both in vivo vitro. During formation atherosclerosis plaque mice, a parallel increase expression levels MLCK miR-92a was observed while reduced ML-7 (an inhibitor...
BACKGROUND: Abdominal aortic aneurysm (AAA) is a complex vascular pathology without pharmaceutical interventions. This study aimed to evaluate whether restoring smooth muscle cell (VSMC) mitochondrial function could prevent AAA development. METHODS: Ang II (angiotensin II)–induced was established in Ldlr -deficient mice, and the gene expression profiles abdominal tissues exhibiting varying degrees of severity were analyzed. Synthetic high-density lipoprotein (sHDL) formulated with Apoa1...
Efficient dye sieving and salt separation can facilitate the recycling of valuable resources in textile wastewater treatment. This study focuses on developing a high-performance nanofiltration membrane (NF) by co-depositing activated polydopamine (O-PDA), oxidized with KMnO4, polyethyleneimine (PEI) onto polysulfone support (PSF), thereby enabling effective separation. Due to high hydrophilicity PDA formation molecular polymers after oxidation, it was anticipated that O-PDA would crosslink...
Abstract It has been known that Rho‐associated protein kinase (ROCK) signaling regulates the migration of vascular smooth muscle cells (VSMCs). However, isoform‐specific roles ROCK and its underlying mechanism in VSMC are not well understood. The current study thus aimed to investigate ROCK1/2 their relationship MAPK pathway platelet‐derived growth factor (PDGF)‐induced rat aorta by manipulating gene expression. results revealed ROCK1 small interfering ribonucleic acid (siRNA) rather than...
Estrogen is traditionally thought to exert genomic actions through members of the nuclear receptor family. Here, we investigated rapid nongenomic effects 17β-estradiol (E2) on tumor necrosis factor α (TNF-α) production following lipopolysaccharide (LPS) stimulation in mouse bone marrow-derived macrophages (BMMs). We found that LPS induced TNF-α BMMs via phosphorylation p38 mitogen-activated protein kinase (MAPK). E2 itself did not affect MAPK pathway, although it attenuated LPS-induced...
Pharmacognosy Magazine,2016,12,45,1-3.DOI:10.4103/0973-1296.175988Published:February 2016Type:Original ArticleAuthors:Yan Xin-Jia, Liu Wei, Zhao Ying, Chen Ning, Xu Wu Jian, Wang Tan, Li Yue, and Xiang Zheng Author(s) affiliations:Yan Xin-Jia1, Wei1, Ying1, Ning1, Jian1, Tan2, Yue2, Zheng1 1 Harbin University of Commerce, 150076, PR China 2 Beijing Center for Physical Chemical Analysis, 100094, Abstract:Results: One new stereoisomer biphenylneolignan with four known compounds was isolated...
Novel components of the mitochondrial fission machinery, dynamics proteins 49 kDa (MiD49) and 51 (MiD51), have been recently described, their potential therapeutic targets for treating cardiovascular disease shown, including acute myocardial infarction (AMI), anthracycline cardiomyopathy pulmonary arterial hypertension (PAH). Here, we examined role MiD49 MiD51 in atherosclerosis. MiD49/51 expression was increased aortic valve endothelial cells (ECs) high-fat diet-induced atherosclerosis...
Salvianolic acid A is a water-soluble component from Danshen, which frequently used in traditional Chinese medicine. High performance liquid chromatography was often to analyze content of salvianolic A. The yield increased by the technological improvement extraction and separation. possessed multiple pharmacological activities, including antioxidants, myocardial ischemic protection, antithrombatic, neuroprotection, anti fibrosis, prevention diabetes complications. Recently, preliminary...
Background: Diabetic cognitive dysfunction (DCD) is one of severe diabetic complications and might develop to irreversible dementia. Early diagnosis detection DCD significant for prevention treatment. Objective: The main objective this study was investigate the amino acid profiles rat with in cerebrospinal fluid (CSF) distinguish early specific biomarkers. Methods: In total, rats were assigned into control model groups. Model induced by intraperitoneal injection streptozotocin. Morris water...
Panax quinquefolius (PQ) and Acorus gramineus (AG) are drug target pairs in traditional Chinese medicine (TCM), which used to treat age-related diseases. In the present study, we simultaneously determined contents of four main bioactive ginsenosides (Rb1, Rb2, Rd, Re) rat plasma using an ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method. Plasma specimens were purified by solid-phase extraction procedure, separation was performed on Waters ACQUITY UPLC...
In response to the planting patterns and trenching fertilization requirements in hilly orchards China, this study employed discrete element simulation software establish soil particle models soil-trenching equipment interaction models. The aim was investigate influence of structural parameters operating on energy consumption segmented trenchers during operation. A surface experimental design adopted simulate process. Based research results regarding effects forward speed, helical...