A5100390181- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Retinoids in leukemia and cellular processes
- Vitamin C and Antioxidants Research
- Renal and related cancers
- Ubiquitin and proteasome pathways
- Protist diversity and phylogeny
- Erythrocyte Function and Pathophysiology
- Advanced Electron Microscopy Techniques and Applications
- Antioxidant Activity and Oxidative Stress
- Microbial metabolism and enzyme function
- Open Source Software Innovations
- Chronic Kidney Disease and Diabetes
- Fungal and yeast genetics research
- Endoplasmic Reticulum Stress and Disease
- PARP inhibition in cancer therapy
- Hereditary Neurological Disorders
- Wnt/β-catenin signaling in development and cancer
- Bioactive Compounds and Antitumor Agents
- Mobile Crowdsensing and Crowdsourcing
- Muscle Physiology and Disorders
- Epigenetics and DNA Methylation
- Synthesis of Organic Compounds
- Metabolism and Genetic Disorders
Hangzhou Cancer Hospital
2022-2025
Qilu Hospital of Shandong University
2024
Sun Yat-sen University
2019-2023
Wuhan University
2023
Shandong University of Traditional Chinese Medicine
2023
Stomatology Hospital
2022-2023
Ethics and Public Policy Center
2022
Weatherford College
2022
SUNY Upstate Medical University
2010
ZheJiang Academy of Agricultural Sciences
2008
Periodontitis is admittedly a microbe-driven intractable infectious disease, in which Porphyromonas gingivalis (Pg) plays keystone role. Pg can selectively impair the antimicrobial responses of periodontal resident macrophages including their phagocytic and bactericidal activity without interfering proinflammatory activity, leads to microflora disturbance, destructive inflammation alveolar bone loss eventually. Here, an injectable ROS-sensitive hydrogel developed for releasing active...
Abstract The relationship of obesity and osteoporosis has been widely studied over the past years. However, implications for bone health remain controversial, underlying molecular mechanism is not yet fully understood. This study demonstrated that high‐fat diet‐induced leads to significantly decreased volume/tissue volume (BV/TV), trabecular number (Tb.N), cortical thickness (Ct.Th) male rat femur after mechanical loading effects body weight were controlled. HFD‐induced obese rats exhibited...
Abstract The meninges produce essential signaling molecules and major protein components of the pial basement membrane during normal brain development. Disruptions in underlie neural ectopia seen those congenital muscular dystrophies (CMDs) caused by mutations genes involved O‐mannosyl glycosylation. In mammals, biosynthesis glycans is initiated a complex mutually indispensable O‐mannosyltransferases 1 2 (POMT1 2). To study roles O‐mannosylation development we generated conditional allele...
Strontium ranelate (SR) is a pharmaceutical agent used for the prevention and treatment of osteoporosis fragility fracture. However, little attention has been paid to effect SR on alveolar bone remodeling during orthodontic tooth movement its underlying mechanism. Here, we investigated influence resorption in Sprague-Dawley rats relationship between nuclear factor-kappa B (NF-κB) pathway, autophagy, osteoclastogenesis after administration vitro vivo. In this study, it was found that reduced...
To verify the role of YAP/WNT5A/FZD4 axis in stretch-induced osteogenic differentiation hPDLCs.During orthodontic tooth movement, human periodontal ligament cells (hPDLCs) at tension side mediates new bone formation. WNT5A promotes osteogenesis and its regulator Yes-associated protein (YAP) is responsive to mechanical stimulation hPDLCs. However, mechanisms YAP alveolar remodeling remain unclear.Cyclic stretch was applied hPDLCs mimic stretching force. Osteogenic determined by alkaline...
Abstract N , ‐dimethylformamide (DMF) is a colorless industrial solvent that frequently used for chemical reactions. Epidemiologic studies and clinical case reports have consistently indicated the main toxic effect after exposure to DMF hepatotoxicity. Previous suggested oxidative stress pivotal molecular event of DMF‐mediated hepatotoxicity; however, its underlying mechanism remains unclear. In this study, we found (0–150 mM) induced an increase in reactive oxygen species (ROS) levels...
Rheumatoid arthritis (RA) is a chronic immune disease involving the small joints, which often causes irreversible damage. In recent years, elevated interleukin 20 (IL-20) has been observed in synovial fluid, while IL-20 receptor overexpression cells. pleiotropic cytokine that participates various diseases. Further understanding of relationship between and RA can help to identify potential clinical treatment for RA. This study demonstrated regulate osteoclast differentiation function...
Epimedium has gained widespread clinical application in Traditional Chinese Medicine, with the functions of promoting bone reproduction, regulating cell cycle and inhibiting osteoclastic activity. However, its precise cellular pharmacological therapeutic mechanism on osteoporosis (OP) remains elusive. This study aims to elucidate molecular epimedium treatment OP based system bioinformatic approach. Predicted targets were collected from TCMSP, BATMAN-TCM ETCM databases. Differentially...
To achieve software crowdsourcing, it is significant to develop a suitable framework for development and quality control motivate workers participate well-perform in crowdsourcing. Although the existing works have achieved some positive results, they do not secure efficient crowdsourcing due "trust" "efficiency" issues. For example, centralized suffers from lack of trust, low reliability, high costs. We first exploit blockchain technologies propose blockchain-empowered decentralized Then we...
Abstract Human urinary induced pluripotent stem cells (hUiPSCs) produced from exfoliated renal epithelial present in urine may provide a non‐invasive source of endothelial progenitors for the treatment ischaemic diseases. However, their differentiation efficiency is unsatisfactory and underlying mechanism still unknown. Gremlin1 (GREM1) an important gene involved cell differentiation. Therefore, we tried to elucidate roles GREM1 during expansion progenitors. HUiPSCs were into by three...
Abstract Ovarian cancer is a disease with increasing incidence worldwide, and there an urgent need for chemotherapy biological targeted therapy.Epithelial-mesenchymal transformation (EMT) important initiation stage tumor cells to acquire the ability invade metastasize.A growing number of findings suggest that human Schlafen family member 5(SLFN5) plays key role in malignancy.However, SLFN5 ovarian has not been fully elucidated.Samples were collected from patients diagnosed Hangzhou First...