A5016165906- Epigenetics and DNA Methylation
- Carbon and Quantum Dots Applications
- Ubiquitin and proteasome pathways
- Genomics, phytochemicals, and oxidative stress
- Cholinesterase and Neurodegenerative Diseases
- interferon and immune responses
- Cell death mechanisms and regulation
- Inflammasome and immune disorders
- Alzheimer's disease research and treatments
- Glutathione Transferases and Polymorphisms
- Lipid metabolism and disorders
- Genetics and Neurodevelopmental Disorders
- PARP inhibition in cancer therapy
- Immune Response and Inflammation
Huazhong University of Science and Technology
2022-2024
During viral infection, sensing of RNA by retinoic acid–inducible gene-I–like receptors (RLRs) initiates an antiviral innate immune response, which is mediated the mitochondrial adaptor protein VISA (virus-induced signal adaptor; also known as signaling [MAVS]). regulated various posttranslational modifications (PTMs), such polyubiquitination, phosphorylation, O -linked β-d- N -acetylglucosaminylation (O-GlcNAcylation), and monomethylation. However, whether other forms PTMs regulate...
Nonsmall cell lung cancer (NSCLC) is highly malignant with limited treatment options, platinum-based chemotherapy a standard for NSCLC resistance commonly seen. cells exploit enhanced antioxidant defense system to counteract excessive reactive oxygen species (ROS), which contributes largely tumor progression and chemotherapy, yet the mechanisms are not fully understood. Recent studies have suggested involvement of histones in cellular response; however, whether major histone variant H1.2...
The redox-active metal ions, especially Cu2+, are highly correlated to Alzheimer's disease (AD) by causing ion-mediated oxidative stress and toxic metal-bound β-amyloid (Aβ) aggregates. Numerous pieces of evidence have revealed that the regulation homeostasis could be an effective therapeutic strategy for AD. Herein, in virtue interaction both amino-containing silane ethylenediaminetetraacetic acid disodium salt silicon–carbon dots (SiCDs) deliberately prepared using these two raw materials...
Methyl‐CpG binding protein 2 (MeCP2) is an important X‐linked DNA methylation reader and a key heterochromatin organizer. The expression level of MeCP2 crucial, as indicated by the observation that loss‐of‐function mutations MECP2 cause Rett syndrome, whereas extra copy spanning locus results in duplication both being progressive neurodevelopmental disorders. Our previous study demonstrated rapidly induced renal ischemia–reperfusion injury (IRI) protects kidney from IRI through...