A5054956422- Restless Legs Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Dysphagia Assessment and Management
- Prion Diseases and Protein Misfolding
- Nutritional Studies and Diet
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Alzheimer's disease research and treatments
- Eating Disorders and Behaviors
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Obesity, Physical Activity, Diet
- Nerve injury and regeneration
- Neurological diseases and metabolism
Ruijin Hospital
2019-2022
Shanghai Jiao Tong University
2019-2022
The University of Texas Health Science Center at Houston
2022
Cerebral microbleeds (CMBs) are frequently found in the healthy elderly. However, data on prevalence and risk factors of CMBs general population China lacking.A cross-sectional study focusing was conducted stroke-free elderly from Shanghai Wuliqiao community. MRI performed at 3Tesla cardiovascular (eg, age, smoking history, hypertension), cerebral small vessel disease (CSVD) markers white matter hyperintensities, lacunar infarction, enlarged perivascular space) genetic information APOE, CR1)...
MAP2K5, a member of the MAPK family, is associated with central nervous system disorders. However, neural functional Map2k5 from animal models were not well examined so far. Here, we established Map2k5-targeted knockout mouse model to investigate behavior phenotypes and its underlying molecular mechanism. Our results showed that female mutant mice manifested decreased circadian-dependent ambulatory locomotion, coordination, fatigue. Male displayed impairment in open field exploration...
<b><i>Backgrounds:</i></b> Several recent case-control studies have suggested some candidate genes being responsible for causing the restless legs syndrome (RLS). However, association between those and risk RLS among Asian population has not been well investigated. <b><i>Objectives:</i></b> The aim of study was to investigate genetic factors Chinese Population. <b><i>Methods:</i></b> A total 158 patients 229 controls...
Extensive experimental and human-derived evidence suggest that misfolded Aβ particles spread similarly to infectious prions. Moreover, peripheral administration of seeds accelerates brain amyloidosis in both susceptible animals humans. The mechanisms elements governing the transport from periphery are not fully understood, although circulation retrograde axonal have been proposed. Here, we demonstrate injection tongue, a highly innervated organ, substantially appearance plaques Tg2576 mice....
ABSTRACT Creutzfeldt-Jakob disease (CJD) is a prion disease, usually presented with memory loss, ataxia, dementia, myoclonus, involuntary movements and psychiatric problems. D178N-homozygous 129M genotype has been recognized in the diagnosis of fatal familial insomnia (FFI) globally. Here we report patient progressive left upper limb stiffness, bradykinesia, hypomimia weight loss (10 kg) initially. She progressed to dysphasia, dysphonia be bedridden quickly but did not present insomnia. was...