A5087375429- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Helicobacter pylori-related gastroenterology studies
- Metal-Organic Frameworks: Synthesis and Applications
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- Circular RNAs in diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Coccidia and coccidiosis research
- Nerve Injury and Rehabilitation
- Silymarin and Mushroom Poisoning
- Helminth infection and control
- Parasitic Infections and Diagnostics
- Hydrogen's biological and therapeutic effects
Zhejiang University
2018-2024
Blood Center of Zhejiang Province
2020-2024
Second Affiliated Hospital of Zhejiang University
2020-2024
Zhejiang Cancer Hospital
2024
Zhejiang Lab
2024
Jinhua Central Hospital
2018-2022
Harbin Medical University
2021
Creative Research Enterprises (United States)
2018
Jinhua Academy of Agricultural Sciences
2018
Chinese Academy of Agricultural Sciences
2005
The incorporation of new modalities into chemotherapy greatly enhances the anticancer efficacy combining merits each treatment, showing promising potentials in clinical translations. Herein, a hybrid nanomedicine (Au/FeMOF@CPT NPs) is fabricated using metal-organic framework (MOF) nanoparticles and gold (Au as building blocks for cancer chemo/chemodynamic therapy. MOF NPs are used vehicles to encapsulate camptothecin (CPT), hybridization by Au improves stability physiological environment....
Abstract Liver fibrosis represents a reversible stage of various chronic liver diseases that progresses to cirrhosis. This condition is characterized by an imbalance between tissue damage and repair, the production fibers in exceeds their degradation. Oxidative stress (OS) resulting from injury endoplasmic reticulum (ERS) triggered overproduction proteins are pivotal factors fibrosis. Melatonin demonstrates capability neutralize free radicals, shielding cells oxidative harm. It also specific...
Abstract Systemic chemotherapy for oral squamous cell carcinoma (OSCC) is associated with multidrug resistance and systemic adverse effects. Cobalt‐ferrocene metal–organic framework (Co‐Fc) a nanoparticle synthetized by ferrocene cobalt stronger Fenton reaction that can locally generate hydroxyl radical effectively kill tumors. However, tumor cells remove exogenous substances through autophagy activity to maintain the internal environment homeostasis. Herein, Co‐Fc loaded classical inhibitor...
Purpose: The purpose of this study was to construct a novel risk scoring model with prognostic value that could elucidate tumor immune microenvironment hepatocellular carcinoma (HCC). Samples and methods: Data were obtained through Cancer Genome Atlas (TCGA) database. Univariate Cox analysis, least absolute shrinkage selection operator (LASSO) multivariate analysis carried out screen for glycolysis-related long noncoding RNAs (lncRNAs) provide value. Finally, we established score describe...
OBJECTIVES: Preoperative decision-making for differentiating malignant from benign lesions in the gallbladder remains challenging. We aimed to create a diagnostic nomogram identify cancer (GBC), especially incidental GBC (IGBC), before surgical resection. METHODS: A total of 587 consecutive patients with pathologically confirmed hospital were randomly assigned training cohort (70%) and an internal validation (30%), 287 other centers as external cohort. Radiological features developed by...
Purpose: Despite considerable efforts to improve treatment modalities for cholangiocarcinoma, a common form of malignant tumor, its long-term survival rate remains poor. Hydroxychloroquine (HCQ) is 4-aminoquinoline derivative antimalarial drug that has and autophagy inhibition effects exhibits comprehensive therapeutic on various cancers. In this study, we aimed explore the anticancer potential underlying molecular mechanism HCQ in cholangiocarcinoma vitro vivo . Methods: Autophagy-related...
Effective and accurate delivery of drugs to tissue with spinal cord injury (SCI) is the key rehabilitating neurological deficits. Sustained-release microspheres (MS) have excellent degradability can aid in long-term release drugs. However, burst phenomenon cause unexpected side effects. Herein, we developed optimized an injectable poly(lactic-co-glycolic acid) (PLGA) MS loaded melatonin(Mel), which were mixed further Laponite hydrogels (Lap/MS@Mel, a micro-gel compound) order reduce MS....
Hepatocellular carcinoma (HCC) is one of the most common and aggressive tumors in world while accuracy present tests for detecting HCC poor. A novel diagnostic prognostic biomarker urgently needed. Overwhelming evidence has demonstrated regulatory roles small nucleolar RNA (snoRNA) carcinogenesis. This study aimed at analyzing expression a snoRNA, SNORA52, exploring correlation between its various clinical characteristics patients. By using quantitative real-time PCR, we found that SNORA52...
Background . Small nucleolar RNAs (snoRNAs) have been proved to play important roles in various cellular physiological process. Recently, dysregulation of snoRNA SNORA71A has found involved tumorigenesis malignant cancers. However, the emerging effects hepatocellular carcinoma (HCC) remain largely unclear. In this study, we aimed explore expression and its underlying significance HCC. Methods Expression cell lines clinical specimens was measured by quantitative real-time PCR. Then, all...
Accumulating evidence suggests that extracellular signal-regulated kinase (ERK) is a valuable target molecule for cancer. However, antitumor drugs targeting ERK are still in their clinical phase and no FDA-approved medications exist. In this study, we identified an inhibitor (ERKi; Vx-11e) with potential activities, which was reflected by the inhibition survival proliferation of Osteosarcoma (OS) cells. Mechanistically, ERKi regulated autophagic flux promoting translocation transcription...
For lack of accurate diagnosis and ideal prognosis assessment, hepatocellular carcinoma (HCC) has become the fourth cancers-related death malignant diseases. Small nuclear RNAs (snRNAs) have been investigated as a new class regulators associated with pathogenesis clinical evaluation tumors such HCC. As for RNU5E-1, one newly identified snRNA, may similar functions. However, relationship between RNU5E-1 expression HCC tumorigenesis remains unclear.The relative was measured in several cell...
Background: Silibinin is widely utilized drug in various cancer treatments, though its application cholangiocarcinoma has not yet been explored. For the first time, we evaluated anticancer potential and underlying molecular mechanism of silibinin treatment treatment. Methods: HuCCT-1 CCLP-1 cells were chosen to be an vitro study model exposed concentrations for indicated times. Cell viability was by cell counting kit-8 (CCK-8) assay half maximal inhibitory (IC50) calculated. proliferation...
Abstract Background: For lack of accurate early diagnosis and prognostic assessment, hepatocellular carcinoma (HCC) becomes severe challenge with the fourth cancer-related mortality. Recently, non-coding RNA (ncRNA) was identified to make functions in progression various tumors. Among that, a novel ncRNA, small nucleolar C/D box 31 (SNORD31) suggested previous study function as potential tumor suppressing role. In present study, we aimed investigate expression patterns clinical significance...
Liver Fibrosis In article number 2310443, Zhengwei Mao, Yuan Ding, Weilin Wang, and co-workers constructed cell membrane-camouflaged nanoparticles (HSCM@PLGA@Melatonin PM@PLGA@Melatonin NPs) using platelet membranes activated hepatic stellate membranes. The release of melatonin targeting the inflamed liver during homing improves endoplasmic reticulum stress oxidative in liver, significantly enhancing therapeutic effect fibrosis.
Background and AimsFor high morbidity mortality, hepatocellular carcinoma (HCC) becomes a major health issue worldwide. Nowadays, numerous non-coding RNAs (ncRNAs) are known to regulate the occurrence pathogenesis of tumors. Some ncRNAs have also been developed as tumor biomarkers therapeutic targets. However, potential function small Cajal body-specific RNA (scaRNA) SCARNA16, newly identified ncRNA, remains be explored in HCC.
Objective To evaluate modified Blumgart anastomosis and conventional in operation time, postoperative pancreatic fistula (POPF) hospital stay patients undergoing pancreaticoduodenectomy (PD). Methods The clinical date of 104 PD with Tianjin Medical University Cancer Hospital from January 1, 2011 to 2015 were retrospectively divided into the group (42 cases) (62 according ways pancreaticojejunostomy was conducted. Results The average time 281±67 minutes, while for traditional...
Rationale: This study explored the safety and feasibility of 3D laparoscopy intraoperative ultrasound techniques, which made minimally invasive pancreatic surgery more precise detailed. Patient concern: Case 1 was a 51-year-old man with primary complaint tumor. 2 60-year-old woman complaints tinnitus for week. 3 21-year-old epigastric pain abdominal distension day. Diagnosis: were diagnosed neuroendocrine tumors, an infected solid pseudopapillary tumor pancreas. Interventions: All patients...
Laparoscopic hepatopancreatoduodenectomy (LHPD) is a complex surgical procedure with high rates of complications and mortality performed in limited number medical centers. The present study reports case synchronous primary malignant tumor the left hepatic common bile ducts. A 63‑year‑old male was admitted to Affiliated Jinhua Hospital, Zhejiang University School Medicine (Jinhua, China) 1 week history right upper abdominal distension pain associated yellow sclera. Preoperative CT MRI imaging...