A5102793199- Breast Cancer Treatment Studies
- Nematode management and characterization studies
- Estrogen and related hormone effects
- Entomopathogenic Microorganisms in Pest Control
- Plant Pathogenic Bacteria Studies
- Tracheal and airway disorders
- Plant-Microbe Interactions and Immunity
- Epigenetics and DNA Methylation
- Advanced Breast Cancer Therapies
- Plant Pathogens and Fungal Diseases
- Gastric Cancer Management and Outcomes
- Species Distribution and Climate Change
- Insect Resistance and Genetics
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Legume Nitrogen Fixing Symbiosis
- RNA modifications and cancer
- Insect and Pesticide Research
- CO2 Reduction Techniques and Catalysts
- Plant and animal studies
- Advanced Photocatalysis Techniques
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Intraperitoneal and Appendiceal Malignancies
Renji Hospital
2006-2024
Shanghai Jiao Tong University
2014-2024
Zhejiang A & F University
2010-2024
Dongyang People's Hospital
2024
Robert Bosch (Germany)
2024
Institute of Catalysis and Petrochemistry
2024
Wenzhou Medical University
2024
Zhejiang University
2020-2023
Jinhua Central Hospital
2020-2021
ORCID
2020
Purpose: The purpose of this study was to construct a novel risk scoring model with prognostic value that could elucidate tumor immune microenvironment hepatocellular carcinoma (HCC). Samples and methods: Data were obtained through Cancer Genome Atlas (TCGA) database. Univariate Cox analysis, least absolute shrinkage selection operator (LASSO) multivariate analysis carried out screen for glycolysis-related long noncoding RNAs (lncRNAs) provide value. Finally, we established score describe...
The fungal microbiota is an important component of the complex multikingdom microbial community colonizing mammalian gastrointestinal tract and has role in immune regulation. However, how fungi regulate inflammatory bowel disease (IBD) poorly understood. This study found that intestinal responses IBD. Antibiotic-mediated depletion facilitated development Fungi greatly enhanced oxidative phosphorylation (OXPHOS) by enhancing glutaminolysis. Mechanistically, we could activate dectin-1-Syk-...
Verticillium dahliae is a destructive, soil-borne pathogen that causes significant losses on numerous important dicots. Recently, beneficial microbes inhabiting the rhizosphere have been exploited and used to control plant diseases. In present study, Burkholderia gladioli KRS027 demonstrated excellent inhibitory effects against wilt in cotton seedlings. Plant growth development was promoted by affecting biosynthesis signaling pathways of brassinosteroids (BRs), gibberellins (GAs), auxins,...
China produces and consumes a large amount of neonicotinoids. A non-negligible exposure to neonicotinoids might occur for Chinese pregnant women, but relevant data remain limited. To investigate the by urinary biomonitoring in women from Wenzhou City, East China. We selected 432 City 2022. total eight parent four metabolites were determined single spot urine liquid chromatography coupled mass spectrometry. Basic characteristics, physical activity, pre-pregnant body index, intake drinking...
BACKGROUND Intraductal oncocytic papillary neoplasm (IOPN) of the pancreas is an extremely rare pancreatic tumor, with only sporadic cases reported in literature. IOPN difficult to diagnose and highly prone misdiagnosis. carries a certain risk progressing invasive cancer. Surgical resection primary treatment for IOPN. According existing literature reports, vast majority patients undergo open surgery, while one case laparoscopic surgery have been reported. CASE SUMMARY This report presents...
Emamectin benzoate (EB) has recently been successfully applied as a trunk injection for preventative control of the pine wilt disease (PWD) caused by Bursaphelenchus xylophilus (Steiner & Buhrer) Nickle. Here, whole-organism transcriptomic analysis provides comprehensive insights into adverse effects EB on B. xylophilus.A large set differentially expressed genes (DEGs) were found, demonstrating antagonistic embryonic and larval development, reproduction, nervous motor systems, pathogenesis....
Metabolic reprogramming is a vital factor in the development of many types cancer, including colon cancer. Serine metabolic major feature tumor metabolism. Yes-associated protein (YAP) participates organ size control and tumorigenesis. However, relationship between YAP serine metabolism cancer unclear. In this study, RNA sequencing metabolomics analyses indicated significant enrichment glycine, serine, threonine pathways starvation–resistant cells. Short-term deficiency inhibited activation,...
Although anti-TNF antibodies are extensively used to treat Crohn's disease (CD), a significant proportion of patients, up 40%, exhibit an inadequate response this therapy. Our objective was identify potential targets that could improve the effectiveness therapy in CD. Through integration and analysis transcriptomic data from various CD databases, we found expression AQP9 significantly increased therapy-resistant specimens. The mouse model enhanced by specifically inhibiting AQP9. Further...
The type III secretion system (T3SS) is considered one of the major virulence factors in many bacterial pathogens. This report demonstrates that RssB, ClpXP, and RpoS play a role T3SS regulation Dickeya dadantii 3937. ClpP serine-type protease which associates with ClpX chaperone to form functional Clp proteolytic complex for degradation proteins. With assistance recognition factor ClpXP degrades sigma factor. positively regulates expression rsmA gene encoding an RNA-binding regulatory...
The hypersensitive response and pathogenicity (hrp) genes of Dickeya dadantii 3937 encode a type III secretion system (T3SS) which is essential for its full virulence. Previous studies the T3SS regulation in D. revealed that expression hrp regulated by master regulator, HrpL, through HrpX-HrpY-HrpS-HrpL GacS-GacA-rsmB-RsmA pathways. In this work, we identified novel regulator SlyA/MarR family, SlyA, regulates HrpL regulon parallel with dadantii. SlyA two-tier manner. It negatively hrpL...
Methionine is one of the essential amino acids. How tumor cells adapt and adjust their signal transduction networks to avoid apoptosis in a methionine-restricted environment worthy further exploration. In this study, we investigated molecular mechanism glioma response methionine restriction, providing theoretical basis for new treatment strategies glioma.We constructed methionine-restriction-tolerant order study environment. The transcriptome analysis tolerant showed significant changes...
Due to climate change, it is significant explore the impact of rising temperatures on distribution Dendrolimus houi Lajonquiere (Lepidoptera) and its host plants, Pinus yunnanensis Cryptomeria fortunei, simulate their suitable future areas in order provide a theoretical basis for monitoring of, early warning about, D. formulation effective prevention control policies. Based known relevant data for, houi, P. yunnanensis, C. habitat China was predicted using ENMeval package adjust maximum...
Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is a currently widely used strategy for locally advanced esophageal cancer (EC). However, the conventional imaging methods have certain deficiencies in evaluation and prediction of efficacy nCRT. This study aimed to explore value functional predicting response neoadjuvant squamous cell carcinoma (ESCC).Fifty-four patients diagnosed with ESCC from August 2017 September 2019 treated nCRT were retrospectively analyzed. DW-MRI scanning was...
The primary culprits of pine wilt disease (PWD), an epidemic forest that significantly endangers the human environment and world’s resources, are pinewood nematodes (PWN, Bursaphelenchus xylophilus). MaxEnt model has been used to predict analyze potential geographic spread PWD in China under effects climate change can serve as a foundation for high-efficiency monitoring, supervision, prompt prevention management. In this work, model’s criteria settings were optimized using data from 646...
Abstract Background Anastomotic leakage (AL) is one of most severe postoperative complications following low anterior resection (LAR) for rectal cancer, and has an adverse impact on recovery. The occurence AL associated with several factors, while few studies explored the role intracorporeal barbed suture reinforcement in it. Methods Consecutive cases underwent laparoscopic LAR cancer from Mar. 2018 to Feb. 2021 our center were retrospectively collected. Cases classified into group control...
Abstract Due to its decade‐long progression, colorectal cancer (CRC) is most suitable for population screening achieve a significant reduction in incidence and mortality. DNA methylation has emerged as potential marker the early detection of CRC. However, current mainstream method represented by bisulfite conversion issues such tedious operation, damage, unsatisfactory sensitivity. Herein, new high‐performance CRC tool based on promising specific terminal‐mediated polymerase chain reaction...
Conidiobolus obscurus is a widespread fungal entomopathogen with aphid biocontrol potential. This study focused on de novo transcriptomic analysis of C. obscurus.A number pathogenicity-associated factors were annotated for the first time from assembled 17 231 unigenes, including those encoding subtilisin-like proteolytic enzymes (Pr1s), trypsin-like proteases, metalloproteases, carboxypeptidases and endochitinases. Many these genes transcriptionally up-regulated by at least twofold in...
Bacteria use signal transduction systems to sense and respond their external environment. The two-component system CpxA/CpxR senses misfolded envelope protein stress responds by up-regulating factors down-regulating virulence in several animal pathogens. Dickeya dadantii is a phytopathogen equipped with type III secretion (T3SS) for manipulating the host immune response. We found that deletion of cpxR enhanced expression T3SS marker gene hrpA designated T3SS-inducing minimal medium (MM). In...
Actinomycetes are an important microbial resource closely related to human production and life. Approximately 70% of the antibiotics currently used produced by various actinomycetes. Pine wilt disease (PWD) is caused pine wood nematode (PWN) (Bursaphelenchus xylophilus), which a devastating forest pest that can cause wilting death trees. The purpose this work was screen out, identify, ferment active actinomycetes with high lethality nematodes study compounds in their secondary metabolites. A...
The aim of the current study was to explore association between age and outcomes in breast cancer.Patients during 2010-2015 were identified from Surveillance, Epidemiology, End Results (SEER) database. Overall survival (OS) cancer-specific death (BCSD) taken as endpoints. restrict cubic spline graph (RCS) used relationship patients, cumulative incidence BCSD non-BCSD calculated using Gray method. Age-specific gene expression profiles studied RNA sequence data Cancer Genome Atlas (TCGA)...