A5108050153- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Cancer-related Molecular Pathways
- Wnt/β-catenin signaling in development and cancer
- Lipid metabolism and biosynthesis
- Flavonoids in Medical Research
- Tendon Structure and Treatment
- Wound Healing and Treatments
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Developmental Biology and Gene Regulation
- Clusterin in disease pathology
- RNA Research and Splicing
- Muscle Physiology and Disorders
- Renal and related cancers
- PI3K/AKT/mTOR signaling in cancer
- TGF-β signaling in diseases
- Histone Deacetylase Inhibitors Research
- Calpain Protease Function and Regulation
- Fibroblast Growth Factor Research
- Nanoplatforms for cancer theranostics
- Aortic Disease and Treatment Approaches
- Cancer Research and Treatments
- Hair Growth and Disorders
- Enhanced Recovery After Surgery
China Agricultural University
2022-2024
Shanghai Children's Hospital
2019-2023
Shanghai Jiao Tong University
2011-2023
University of Science and Technology of China
2023
First Affiliated Hospital of Henan University
2023
Shandong Provincial Hospital
2023
Shandong First Medical University
2023
Peking University
2022
Peking University Third Hospital
2022
Capital Medical University
2021-2022
Periostin is a multifunctional extracellular matrix protein involved in various inflammatory diseases and tumor metastasis; however, evidence regarding whether how periostin actively contributes to inflammation-associated tumorigenesis remains elusive. Here, we demonstrate that deficiency significantly inhibits the occurrence of colorectal cancer azoxymethane/dextran sulfate sodium-treated mice ApcMin/+ mice. Moreover, attenuates severity colitis reduces proliferation cells. Mechanistically,...
Mechanical stimulation and histone deacetylases (HDACs) have essential roles in regulating the osteogenic differentiation of bone marrow stromal cells (BMSCs) formation. However, little is known regarding what regulates HDAC expression therefore BMSCs during osteogenesis. In this study, we investigated whether mechanical loading directly examined role HDACs loading-triggered We first studied microarrays samples from patients with osteoporosis found that NOTCH pathway skeletal development...
Abstract The Drosophila Eyes Absent Homologue 1 (EYA1) is a component of the retinal determination gene network and serves as an H2AX phosphatase. cyclin D1 encodes regulatory subunits holoenzyme that phosphorylates inactivates pRb protein. Herein, comparison with normal breast showed EYA1 overexpressed in luminal B cancer subtype. enhanced tumor growth mice vivo, requiring phosphatase domain. cellular proliferation, inhibited apoptosis, induced contact-independent abundance. induction...
Re-epithelialization is a complex process during skin wound healing, and cell migration an integral part of this phenomenon. Here we identified role for LRG1 as key regulator epidermal keratinocyte where acts via enhancement HIF-1α stability. We showed that upregulated at murine edges addition recombinant human accelerates healing. Furthermore, transcription factor ELK3 downstream effector LRG1. confirmed elevated levels manipulated by can promote through upregulation Because hyperglycemia...
We examined the impact of statins on Yes-associated Protein (YAP) localization, phosphorylation and transcriptional activity in human mouse pancreatic ductal adenocarcinoma (PDAC) cells. Exposure sparse cultures PANC-1 MiaPaCa-2 cells to cerivastatin or simvastatin induced a striking re-localization YAP from nucleus cytoplasm inhibited expression YAP/TEAD-regulated genes Connective Tissue Growth Factor (CTGF) Cysteine-rich angiogenic inducer 61 (CYR61). Statins also prevented nuclear import...
Abstract Biomechanical force and pathological angiogenesis are dominant features in fibro-proliferative disorders. Understanding the role regulation of mechanical microenvironment which occurs is an important challenge when investigating numerous angiogenesis-related diseases. In skin fibrosis, dermal fibroblasts vascular endothelial cells integral to hypertrophic scar formation. However, few studies have been conducted closely investigate their relationship. Here we show, that...
Emerging evidence shows that Hippo signal pathways can regulate the progression of various cancer. While roles Yes-associated protein (YAP), key transducer signals, in development endometrial cancer (EC) are rarely investigated.The expression YAP cells and tissues was measured. Its proliferation interleukins (ILs) were investigated by use its specific siRNA or inhibitor (verteporfin, VP).YAP upregulated tissues. Knockdown VP suppress while increase chemo-sensitivity EC cells. We found...
Background/Aims: Paclitaxel (PTX) is one of the most effective anti-cancer drugs. However, multiple drug resistance still main factor that hinders treatment cancer with PTX. Several factors including YAP over-expression can cause PTX resistance. In this study, we aimed to verify role plays in resistance, explore reversal by verteporfin (VP) and investigate effect combination therapy VP on resistant colon cells (HCT-8/T). Methods: To study relationship between a stable YAP-over-expression or...
Macrophages (Mφs) can be used as a part of cell‐based cancer immunotherapy. However, they may hampered by failure to effectively and stably regulate their polarization state enhance tumoricidal effects. In this work, mechanical stretch (MS), biology‐free modulatory method, was shown M1 By using an in vitro Flexcell Tension system, we found that murine Mφ RAW264.7 cells showed higher polarization‐related mRNA expression cytokine release after MS. Further molecular analyses focal adhesion...
Metabolic reprogramming is a vital factor in the development of many types cancer, including colon cancer. Serine metabolic major feature tumor metabolism. Yes-associated protein (YAP) participates organ size control and tumorigenesis. However, relationship between YAP serine metabolism cancer unclear. In this study, RNA sequencing metabolomics analyses indicated significant enrichment glycine, serine, threonine pathways starvation–resistant cells. Short-term deficiency inhibited activation,...
The pathogenesis and therapy of hypertrophic scars (HS) have not yet been established. aim the present study was to investigate potential effect naringenin on HS its underlying mechanisms. mouse model prepared by a mechanical stretch device then treated with at various concentrations. Histological studies were performed evaluate scar hypertrophy hematoxylin eosin, as well Masson's trichrome staining. activation fibroblasts determined based reverse transcription‑quantitative polymerase chain...
Defective skeletal muscle regeneration is often accompanied by fibrosis. Fibroblast/adipose progenitors (FAPs) are important in these processes, however, the regulation of FAP fate decisions unclear. Here, using inducible conditional knockout mice, we show that blocking mammalian Ste20-like kinases 1/2 (MST1/2) FAPs prevented apoptosis and reduced interleukin-6 secretion vivo vitro, which impaired myoblast proliferation differentiation, as well regeneration. Deletion Mst1/2 increased...
Skin fibrosis is mainly characterized by excessive collagen deposition. Studies have recently identified a number of flavonoids with variable structures that the potency inhibiting synthesis and thus attenuating organ fibrosis. In this study, we found flavones 5, 7, 3', 4' hydroxy substitution reduced expression most efficiently. Among those flavones, luteolin, quercetin, myricetin were selected for follow-up. vivo, three compounds ameliorated skin Further analysis showed had significant...
// Guanglin Xu 1, 2, 3 , Jing Wang 1 Fangfang Wu Na Wenli Zhou Qian Pan Guizhen Ao 4 Jiquan Yang 2 College of Life Sciences, Nanjing Normal University, Nanjing, China Jiangsu Key Laboratory 3D Printing Equipment and Manufacturing, for Molecular Medical Biotechnology, Science, Department Medicinal Chemistry, School Pharmacy, Soochew Jiangsu, Correspondence to: Yang, email: xudunlop@126.com Keywords: YAP, 14-3-3, COX-2, HCC, Hep G Received: March 31, 2016 Accepted: June 30, Published: July 18,...
This study aimed to evaluate the inhibitory effects of herbal extracts on caries-related bacteria, glucan and biofilm in vitro. Sensitive tests bacteria were carried out by broth dilution method a 96-microwell plate. Glucan inhibition using phenol sulphate method. A minimum concentration (MBIC) test was performed an artificial mouth model. The results MBIC agents 8, 16 32 mg mL−1 for eugenol, tannic acid magnolol, respectively. For tests, over 63%, 28% 27% occurred insoluble syntheses...