Abstract Hypertrophic scar (HS) formation is a skin fibroproliferative disease that occurs following cutaneous injury, leading to functional and cosmetic impairment. To date, few therapeutic treatments exhibit satisfactory outcomes. The mechanical force has been shown be key regulator of HS formation, but the underlying mechanism not completely understood. Piezo1 channel identified as novel mechanically activated cation (MAC) reportedly capable regulating force-mediated cellular biological...

Abstract Skin fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) caused fibrotic disorders skin. In recent years, ECM stiffness has emerged as a prominent mechanical cue that precedes skin and drives its progression promoting fibroblasts activation. However, how influences activation for remains unknown. Here, we report positive feedback loop mediated mechanosensitive ion channel Piezo1 aberrant tissue mechanics in driving fibrosis. upregulated both humans...

The increased mechanics of fibrotic skin tissue continuously regulate fibroblast functions such as survival and differentiation. Although all these processes consume metabolites, it is unclear whether how cells adapt their metabolic activity to matrix stiffness. Here, we show that transferring mouse dermal fibroblasts from soft stiff substrates causes an up-regulation arginine proline metabolism. Increased stiffness stimulates the expression key enzymes, leading synthesis L-proline, a major...

Content adaptation is an important technique for mobile devices. Existing content systems have been developed with specific goals. In this paper, we present extensible system, Xadaptor. We take a rule-based approach to facilitate extensible, systematic, and adaptive adaptation. It integrates mechanisms various types organizes them into the rule base. Rules are invoked based on individual client information. classify HTML page objects structure, content, pointer objects. techniques mainly...

Macrophages (Mφs) can be used as a part of cell‐based cancer immunotherapy. However, they may hampered by failure to effectively and stably regulate their polarization state enhance tumoricidal effects. In this work, mechanical stretch (MS), biology‐free modulatory method, was shown M1 By using an in vitro Flexcell Tension system, we found that murine Mφ RAW264.7 cells showed higher polarization‐related mRNA expression cytokine release after MS. Further molecular analyses focal adhesion...

In this study, infrared thermography is used for vibration-based structural health monitoring (SHM). Heat sources are employed as sensors. An acrylic frame structure was experimentally investigated using the heat marker points to record vibration response. The effectiveness of measurement system verified by comparing results obtained an thermal imager with those accelerometers. average error in natural frequency between only 0.64% and 3.84%. To guarantee applicability system, study mode...

We report a series of novel poly(ethylene terephthalate) (PET) copolymers with improved properties through the incorporation bioadvantaged dimethyl 2,7-naphthalenedicarboxylate (2,7-N) as comonomer. PET is among most commonly used engineering thermoplastics, ubiquitous in food packaging industry. However, its application limited by poor thermal (low Tg) and oxygen barrier performance. A terephthalate-stat-2,7-naphthalate) were synthesized from ethylene glycol (EG), terephthalic acid (TPA),...

The epithelial-mesenchymal transition (EMT) process has emerged as a central regulator of embryonic development, tissue repair and tumor malignancy. In recent years, researchers have specifically focused on how mechanical signals drive the EMT program in epithelial cells. However, cells leverage force to control remains unclear. Here, we show that bona fide mechanically activated cation channel Piezo1 plays critical role EMT. is expressed human primary epidermal keratinocytes (HEKs)...

A miniaturized dual-band dual-beam filtering patch antenna with orthogonal beam pointing is proposed. By using a cross-shaped feedline two pairs of common-mode (CM) currents, TM02 and TM20 modes are excited suppression adjacent TM10 TM12 modes, radiation null 1 (RN1) introduced in both polarizations. Due to far-field nulls patterns, intrinsic (RN <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$_{\mathrm...

Abstract This paper presents a tunable planar auxetic metamaterial (PAM) for controlling and filtering acoustic waves provides guidelines bandgap design of the proposed PAMs. Numerical results deformed undeformed PAMs were obtained from several finite element analyses based on Bloch–Floquet theory. The band structures calculated with periodic boundaries. Tunable bandgaps in certain frequency ranges generated by various deformations applied to Wave attenuation experimental transmission loss...

In this paper, the design of an ultra-wideband polarizer based on a metasurface with high-performance is reported and demonstrated. The composed dielectric substrate double semicircular gap patches metal film. Multiple strong resonance points enable to convert incident linearly polarized waves into cross-polarized in 14.8–28.0 GHz range, fractional bandwidth 61.7% corresponding polarization conversion rate (PCR) above 95%. Further simulated results show that PCR remains 87% 14.37–24.75 range...

A combination tillage with disks, rippers, and roller baskets allows the loosening of compacted soils crumbling soil clods. Statistical methods for evaluating tilth quality are limited. Light Detection Ranging (LiDAR) data machine learning models (Random Forest (RF), Support Vector Machine (SVM), Neural Network (NN)) proposed to investigate basket pressure settings on quality. Soil profiles were measured using LiDAR (stop go on-the-go) RGB visual images from a Completely Randomized Design...

Hardware data prefetching is a well-studied technique to bridge the processor-memory performance gap. Bit-pattern-based prefetchers are one of most promising spatial that achieve substantial gains. In bit-pattern-based prefetchers, region size crucial parameter, which denotes memory can be recorded by pattern or prefetched prediction. However, existing only support fixed size. Our experiment shows cannot meet requirements for numerous applications and leads suboptimal high hardware overhead....

Basic helix-loop-helix (bHLH) transcription factors (TFs) participate in many physiological and cellular processes eukaryotes. However, their functions remain unclear the macro basidiomycete Ganoderma lucidum (G. lucidum). In this study, a gene encoding bHLH TF, GlbHLH, was identified G. lucidum. The knockdown of GlbHLH by RNA interference reduced hyphal growth, branching, resistant to osmotic, oxidative, cell wall stress. content components β-1,3 glucan chitin expression synthesis genes...

Abstract Arbitrarily manipulating the polarization states of electromagnetic waves has gained interest due to its wide application in modern wireless communication systems. However, conventional polarizers face major bottlenecks such as bulky size, low efficiency and narrow frequency band. This paper proposes a reflective linear-to-circular polarizer using Wi-Fi shaped metasurface, designed can efficiently convert linearly polarized incident into nearly perfect circularly reflected wideband...

Myofibroblasts contribute to the excessive production, remodeling and cross-linking of extracellular matrix that characterizes progression skin fibrosis. An important insight into pathogenesis tissue fibrosis has been discovery increased stiffness during is involved in myofibroblast activation. However, mechanistic basis for this phenomenon remains elusive.

Micro-arrayed donut-shaped chambers (DSCs) in a range of volumes (fL to nL) have been developed and produced for various biochemical reaction measurements offer an inexpensive simple system live cell analysis the corresponding single content.

In this paper, an ultra-wideband (UWB) polarizer with high performance based on the metasurface is designed and demonstrated, which composed of a dielectric substrate double-gap circular pattern metal film. Multiple strong resonance points enable design to achieve conversion from incident linearly polarized waves cross-polarized at 6.49–11.64 GHz, fractional bandwidth 56.8% corresponding polarization rate (PCR) 90%. The PCR remains above 90% 6.49–11.52 GHz when electromagnetic wave obliquely...

Abstract Background: Scleroderma is characterized by inflammation and fibrosis, predominantly occurring in the skin extending to various parts of body. The pathophysiology scleroderma multifaceted, with current understanding including endothelial damage, inflammatory cell infiltration, fibroblast activation its progression. Nonetheless, mechanism cellular interactions precise spatial distribution these events within fibrotic tissues remain elusive, highlighting a critical gap our...

Abstract Point cloud segmentation and recognition for virtual 3D wind turbine modeling in thermal plants are disjointed, limiting coverage elevating mean square error. A design leveraging bilateral filtering of point data is proposed to address this. This approach encompasses acquisition, preprocessing, multi-level enhance coverage. Bilateral then applied calculate the model, with edge correction verification. Tests reveal that compared traditional k-means clustering, reduced project space,...