A5052522513- Dermatologic Treatments and Research
- Wound Healing and Treatments
- Cellular Mechanics and Interactions
- Algal biology and biofuel production
- Erythrocyte Function and Pathophysiology
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Tendon Structure and Treatment
- Epigenetics and DNA Methylation
- Erythropoietin and Anemia Treatment
- Histone Deacetylase Inhibitors Research
- Aquaculture Nutrition and Growth
- Hippo pathway signaling and YAP/TAZ
- Laser Applications in Dentistry and Medicine
- Blood properties and coagulation
- Ubiquitin and proteasome pathways
- Skin and Cellular Biology Research
- Connective Tissue Growth Factor Research
- Body Contouring and Surgery
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Hair Growth and Disorders
- Inflammatory mediators and NSAID effects
- Burn Injury Management and Outcomes
- Cancer, Lipids, and Metabolism
Ocean University of China
2025
Chengde Medical University
2025
MedStar Union Memorial Hospital
2025
Liaoning University of Traditional Chinese Medicine
2025
Shanghai Ninth People's Hospital
2015-2024
Shanghai Jiao Tong University
2015-2024
Ningbo University
2023-2024
Nanjing Drum Tower Hospital
2024
Tianjin First Center Hospital
2024
Tianjin Medical University
2024
Tie2 is a novel receptor tyrosine kinase that expressed almost exclusively by vascular endothelium. Disruption of function in transgenic mice resulted embryonic lethality secondary to characteristic defects; similar defects occurred after disruption the ligand. These findings indicate Tie2/Tie2 ligand pathway plays important roles during development vasculature. To determine whether was involved pathologic angiogenesis adult tissues, soluble form extracellular domain murine (ExTek.6His)...
Abstract Hypertrophic scar (HS) formation is a skin fibroproliferative disease that occurs following cutaneous injury, leading to functional and cosmetic impairment. To date, few therapeutic treatments exhibit satisfactory outcomes. The mechanical force has been shown be key regulator of HS formation, but the underlying mechanism not completely understood. Piezo1 channel identified as novel mechanically activated cation (MAC) reportedly capable regulating force-mediated cellular biological...
Mechanical stimulation and histone deacetylases (HDACs) have essential roles in regulating the osteogenic differentiation of bone marrow stromal cells (BMSCs) formation. However, little is known regarding what regulates HDAC expression therefore BMSCs during osteogenesis. In this study, we investigated whether mechanical loading directly examined role HDACs loading-triggered We first studied microarrays samples from patients with osteoporosis found that NOTCH pathway skeletal development...
Bone morphogenetic protein 2 (BMP2) has been used to induce bone regeneration by promoting osteogenic differentiation of marrow-derived mesenchymal stem cells (MSCs). However, its effect is attenuated in osteoporotic conditions unknown mechanisms. In this study, we investigated the molecular mechanisms reduced BMP2 conditions. By interrogating microarray data from osteoporosis patients, revealed an upregulation epigenetic modifying lysine (K)-specific demethylase 5A (KDM5A) and decreased...
Abstract Skin fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) caused fibrotic disorders skin. In recent years, ECM stiffness has emerged as a prominent mechanical cue that precedes skin and drives its progression promoting fibroblasts activation. However, how influences activation for remains unknown. Here, we report positive feedback loop mediated mechanosensitive ion channel Piezo1 aberrant tissue mechanics in driving fibrosis. upregulated both humans...
Obesity and its associated metabolic disorders such as diabetes, hepatic steatosis chronic heart diseases are affecting billions of individuals. However there is no satisfactory drug to treat diseases. In this study, we found that alisol A, a major active triterpene isolated from the Chinese traditional medicine Rhizoma Alismatis, could significantly attenuate high-fat-diet-induced obesity. Our biochemical detection demonstrated A remarkably decreased lipid levels, alleviated glucose...
Adipose-derived stem cells (ADSCs) are a subset of mesenchymal (MSCs), which have promised vast therapeutic potential in tissue regeneration. Recent studies demonstrated that combining with mechanical stretch may strengthen the efficacy regenerative therapies. However, exact influences on MSCs still remain inconclusive. In this study, human ADSCs (hADSCs) were applied cyclic stimulation under an vitro stretching model for designated duration. We found significantly promoted proliferation,...
Journal Article Baicalein attenuates hypertrophic scar formation via inhibition of the transforming growth factor‐β/Smad2/3 signalling pathway Get access Y.F. Zhang, Zhang Department Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Jiao Tong University 200011 China Search for other works by this author on: Oxford Academic Google Scholar S.Z. Zhou, Zhou X.Y. Cheng, Cheng Anesthesiology Renji Hospital; School Medicine B. Yi, Yi Clinical College General Beijing Military...
Macrophages (Mφs) can be used as a part of cell‐based cancer immunotherapy. However, they may hampered by failure to effectively and stably regulate their polarization state enhance tumoricidal effects. In this work, mechanical stretch (MS), biology‐free modulatory method, was shown M1 By using an in vitro Flexcell Tension system, we found that murine Mφ RAW264.7 cells showed higher polarization‐related mRNA expression cytokine release after MS. Further molecular analyses focal adhesion...
The increased mechanics of fibrotic skin tissue continuously regulate fibroblast functions such as survival and differentiation. Although all these processes consume metabolites, it is unclear whether how cells adapt their metabolic activity to matrix stiffness. Here, we show that transferring mouse dermal fibroblasts from soft stiff substrates causes an up-regulation arginine proline metabolism. Increased stiffness stimulates the expression key enzymes, leading synthesis L-proline, a major...
Transplantation of adipose-derived stem cells (ASCs) is a promising option in the field chronic wounds treatment. However, effectiveness ASCs therapies has been hampered by highly inflammatory environment wound areas. These problems could be partially circumvented using efficient approaches that boost survival and anti-inflammatory capacity transplanted ASCs. Here, application mechanical stretch (MS), we show exhibits increased immunoregulatory properties vitro. MS triggers secretion...
Tumour hypoxia has been shown to increase mutation rate, angiogenesis, and metastatic potential, decrease response conventional therapeutics. Improved tumour oxygenation should translate into increased treatment response. Exogenous recombinant erythropoietin (rEpo) recently in a mammary carcinoma model. The mechanism of this action is not yet understood completely. presence Epo its receptor (EpoR) have demonstrated on several normal neoplastic tissues, including blood vessels various solid...
Alzheimer's disease (AD), the most common form of dementia, currently has no effective cure. Epimedii Folium (EF), a traditional Chinese medicine known as Yin-yang-huo, demonstrated significant neuroprotective properties. In this study, neural stem cells overexpressing APPswe gene (APP-NSCs) were used an in vitro AD model. The CCK-8, LDH, neurosphere formation, and BrdU incorporation assays employed to identify bioactive metabolite EF promoting NSC proliferation. Subsequently, JC-1 staining,...
This study aims to investigate the scientificity and efficacy of compatibility Jinlingzi San from pharmacokinetics. Liquid chromatography-tandem mass spectrometry(LC-MS/MS) was utilized determine plasma concentrations active components: toosendanin, tetrahydropalmatine A, B at various time points following gavage its single medicines in rats. Subsequently, WinNonlin employed calculate pertinent pharmacokinetic parameters. The parameters rat were compared between compound formula San. It...
Hypertrophic scar (HPS) presents as excessive extracellular matrix (ECM) deposition and abnormal function of fibroblasts. However, there is no single satisfactory method to prevent HPS formation so far. Here we found that honokiol (HKL), a natural compound isolated from Magnolia tree, had an inhibitory effect on both in vitro vivo. Firstly, HKL could dose-dependently down regulate the mRNA protein levels type I collagen (COL I), III III) α-smooth muscle actin (α-SMA) hypertrophic...
The pathogenesis and therapy of hypertrophic scars (HS) have not yet been established. aim the present study was to investigate potential effect naringenin on HS its underlying mechanisms. mouse model prepared by a mechanical stretch device then treated with at various concentrations. Histological studies were performed evaluate scar hypertrophy hematoxylin eosin, as well Masson's trichrome staining. activation fibroblasts determined based reverse transcription‑quantitative polymerase chain...