A5101860985- Breast Cancer Treatment Studies
- Estrogen and related hormone effects
- Colorectal Cancer Treatments and Studies
- Cancer Risks and Factors
- Advanced Breast Cancer Therapies
- Hepatocellular Carcinoma Treatment and Prognosis
- Statistical Methods and Inference
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Statistical Methods and Bayesian Inference
- Neuroendocrine Tumor Research Advances
- Advanced Causal Inference Techniques
- Breast Lesions and Carcinomas
- Colorectal Cancer Screening and Detection
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Wnt/β-catenin signaling in development and cancer
- Global Cancer Incidence and Screening
- Colorectal and Anal Carcinomas
- Healthcare Systems and Challenges
- Infection Control and Ventilation
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
Zhejiang University
2016-2023
Second Affiliated Hospital of Zhejiang University
2016-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2021
University Gastroenterology
2020
Zero to Three
2017
The features related to the prognosis of patients with mucinous breast cancer (MBC) remain controversial. We aimed explore prognostic factors MBC and develop a nomogram for predicting survival outcomes.The Surveillance, Epidemiology, End Results (SEER) database was searched identify 139611 women resectable from 1990 2007. Survival curves were generated using Kaplan-Meier methods. 5-year 10-year cancer-specific (CSS) rates calculated Life-Table method. Based on Cox models, constructed predict...
Senescent microenvironments play an important role in tumor progression. Here, we report that doxorubicin ( DOX )‐pretreated or replicative senescent stromal cells WI ‐38 and HUVEC ) promote colorectal cancer CRC cell growth invasion vitro vivo . These pro‐tumorigenic effects were attenuated by exogenous administration of Klotho, anti‐aging factor. We subsequently identified several senescence‐associated secretory phenotype SASP )‐associated genes, including CCL 2, which significantly...
Small intestinal neuroendocrine tumors (SiNETs) without distant metastasis typically behave in an indolent manner, but there can be heterogeneity. We aimed to define the survival outcomes and impacts of surgical intervention.A retrospective cohort study was conducted by using data from Surveillance, Epidemiology, End Results (SEER) database. Clinicopathologic features were analyzed 4407 patients between 2000 2012. The cancer specific (CSS) calculated Kaplan-Meier method. Multivariable Cox...
Gastric cancer (GC) patients with metastasis had limited treatment options and dismal outcome. We have previously reported the aberrant expression of Zic family member 1 (Zic1) in GC. However, functional roles underlying mechanism Zic1 GC remain unknown. Here, we demonstrate that lower was correlated more lymph node poor outcome patients. Ectopic suppressed both lung peritoneal tumor dissemination mice. The metastatic suppressing ability mediated by regulating process cell invasion, adhesion...
BACKGROUND The real‐world occurrence rate of non–breast cancer–specific death (non‐BCSD) and its impact on patients with breast cancer are poorly recognized. METHODS Women resectable from 1990 to 2007 in the Surveillance, Epidemiology, End Results database (n = 199,963) were analyzed. outcome events classified as (BCSD), non‐BCSD, or survival. Binary logistics was used estimate rates non‐BCSD BCSD different clinicopathological factors. Gray method measure cumulative incidence BCSD. ratio...
Signet ring cell carcinoma (SRCC) is a uniquely separated subgroup in metastatic colorectal cancer (mCRC). The aims are to investigate the value of resection patients with resectable signet cancer.Patients mCRC who underwent Surveillance, Epidemiology, and End Results database during 1998-2010 were retrospectively analyzed. Kaplan-Meier COX models used analyze differences survival. Logistic regression evaluate relationship between SRCC other clinicopathological factors.Among 3,568 patients,...
<b><i>Background:</i></b> The effectiveness of the current Tumor, Lymph node, Metastases (TNM) staging system in small intestinal neuroendocrine tumors (SiNETs) is unsatisfactory. Current N classification only distinguishes between node-negative and node-positive status. We aim to refine for updated TNM stage. <b><i>Methods:</i></b> During period from 1988 2012, patients with non-metastatic SiNETs were enrolled Surveillance, Epidemiology, End...
Although it is widely accepted that hormone receptor (HR) status associated with later post-diagnostic periods, a debate exists as to whether the association independent of age. The aim our study was confirm impact HR on period breast cancer-specific death (LP-BCSD) and non-breast (LP-non-BCSD) in different age subgroups.Surveillance, Epidemiology, End Results databases were utilized identify 181,108 cancer patients > 5 years survival. cumulative incidence LP-BCSD LP-non-BCSD calculated...
Although adjuvant chemotherapy is recommended for patients with stage II colon cancer characterized by poor prognostic features, its pros and cons remain a controversial issue. We aim to evaluate the real effectiveness of on as well select suitable patients.Patients during 1988-2013 were identified from Surveillance, Epidemiology, End Results (SEER) database. The competing risk regression model propensity score matching method used colon-cancer-specific death (CCSD) non-CCSD. Also,...
Clinically, a considerable portion of patients with early T stage who were supposed to have low distant metastatic probability diagnosed liver colorectal cancer (CRLM). Our study aims evaluate the prognostic value for and establish convenient individual assessment model clinicians explore preoperative predictors. The mRNA profiles tumors (N = 19) obtained by microarray at our clinical center. A total 5,618 CRLM from 2010 2015 enrolled Surveillance, Epidemiology, End Results (SEER) database....
The number of reported young breast cancer cases has increased dramatically recently.The impact age on the outcomes cancers remains controversial.Our study aimed to explore factors that can stratify prognosis early patients.In total, 244,324 patients with in Surveillance, Epidemiology, and End Results database were identified from 1990 2007.Survival curves generated using Kaplan-Meier method.The 5-and 10-year cancer-specific survival (CSS) rates calculated Life-Table method.Multivariable...
Abstract Background Distant metastasis (DM) is relatively rare in superficial gastric cancer (SGC), especially patients without lymph node metastasis. This study aimed to explore the main clinical risk factors for DM with cancer‐no (SGC‐NLNM) and prognostic DM. Methods Records of SGC‐NLNM between 2004 2015 were collected from public Surveillance, Epidemiology, End Results (SEER) database. Both univariate multivariate logistic regressions performed analyze The Kaplan–Meier method Cox...
To evaluate the value of lymph node status primary tumors in predicting prognosis synchronous resectable metastatic colorectal cancer (mCRC).The characteristics mCRC are substantially different from other cancers, and prognostic factors still controversial.The data 2007 patients with who received resection lesions synchronously were reviewed Surveillance, Epidemiology End-Result database. The Kaplan-Meier method was used to capacity factors. Univariate multivariate logistic regression models...
The Kaplan–Meier method and Cox proportional hazards regression model are the most common analyses in survival framework. These relatively easy to apply interpret can be depicted visually. However, when competing events (e.g., cardiovascular cerebrovascular accidents, treatment-related deaths, traffic accidents) present, standard methods should applied with caution, real-world data cannot correctly interpreted. It may desirable distinguish different kinds of that lead failure treat them...
The Kaplan–Meier method and Cox proportional hazards regression model are the most common analyses in survival framework. These relatively easy to apply interpret can be depicted visually. However, when competing events (e.g., cardiovascular cerebrovascular accidents, treatment-related deaths, traffic accidents) present, standard methods should applied with caution, real-world data cannot correctly interpreted. It may desirable distinguish different kinds of that lead failure treat them...
e15049 Background: T classification is considered as a detail and credible category of the depth tumor invasion. Generally, with increasing category, risk metastases should be continuously rising. However, there group metastatic patients early classification, who were supposed to have low probability. Our study aims present on liver colorectal cancer (CRLM) in both clinical biological aspects, explore preoperative predictions develop convenient individual assessment model for clinicians...
Background: The estrogen receptor (ER)-negative/progesterone (PR)-positive (sPR positive) phenotype is an infrequent and independent biological entity. However, the prognosis of patients with sPR positive her-2 negative still controversial, it not always easy to decide treatment strategies for them. Methods: Patients during 2010–2014 were identified from Surveillance, Epidemiology, End Results (SEER) database. Kaplan-Meier method was used evaluate cancer-specific survival (CSS). propensity...
Abstract Background: The estrogen receptor (ER)-negative/progesterone (PR)-positive (sPR positive) phenotype is an infrequent and independent biological entity. However, the prognosis of patients with sPR positive her-2 negative still controversial, it not always easy to decide treatment strategies for them. Methods: Patients during 2010–2014 were identified from Surveillance, Epidemiology, End Results (SEER) database. Kaplan-Meier method was used evaluate cancer-specific survival (CSS)....
Objective: To analyze the clinicopathological features and prognostic factors of patients with uterine clear cell carcinoma (UCCC). Methods: UCCC who underwent surgery complete follow-up at Cancer Hospital, Chinese Academy Medical Sciences Peking Union College between January 1, 2004 December 31, 2014 were retrospectively reviewed. The Kaplan-Meier method Cox regression analysis used for survival analysis. Results: study included 34 patients. Only 18 (52.9%) diagnosed preoperatively 8...