A5022376467- Cancer Cells and Metastasis
- interferon and immune responses
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Estrogen and related hormone effects
- Cancer-related Molecular Pathways
- Cytomegalovirus and herpesvirus research
- Pluripotent Stem Cells Research
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
- Endoplasmic Reticulum Stress and Disease
- Calcium signaling and nucleotide metabolism
- Genomics and Chromatin Dynamics
- Immune cells in cancer
- Immune Cell Function and Interaction
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Phagocytosis and Immune Regulation
- Zebrafish Biomedical Research Applications
- Cancer Immunotherapy and Biomarkers
The University of Texas Southwestern Medical Center
2012-2024
Southwestern Medical Center
2022-2024
Zhejiang University
2014-2023
Resident and inflammatory mononuclear phagocytes (MPhs) with functional plasticity in the intestine are critically involved pathology of bowel diseases (IBDs), mechanism which remains incompletely understood. In present study, we found that increased expression E3 ligase F-box WD repeat domain–containing 7 (FBXW) inflamed was significantly correlated IBD severity both human mouse models. Myeloid Fbxw7 deficiency protected mice from colitis induced by dextran sodium sulfate (DSS) or...
Activation of the cGAS-STING pathway is traditionally considered a "trigger-release" mechanism where detection microbial DNA or cyclic di-nucleotides sets off type I interferon response. Whether this can be activated without pathogenic ligand exposure less well understood. Here we show that loss Golgi-to-lysosome STING cofactors, but not ER-to-Golgi selectively activates tonic signalling. Impairment post-Golgi trafficking extends Golgi-dwell time, resulting in elevated immune signalling and...
The presence of cancer stem cells (CSC), which possess the ability self-renewal and initiation, is correlated with poor prognosis drug resistance breast patients. But molecular regulatory networks for maintenance CSC function still remain unclear. Here, we identified that an estrogen-inducible gene FXYD3, whose expression significantly upregulated in ER+ CSCs, a critical player regulating function. FXYD3 amplification crucial mediating tamoxifen cells. Interestingly, also find cell-related...
Gastric cancer (GC) patients with metastasis had limited treatment options and dismal outcome. We have previously reported the aberrant expression of Zic family member 1 (Zic1) in GC. However, functional roles underlying mechanism Zic1 GC remain unknown. Here, we demonstrate that lower was correlated more lymph node poor outcome patients. Ectopic suppressed both lung peritoneal tumor dissemination mice. The metastatic suppressing ability mediated by regulating process cell invasion, adhesion...
Abstract Three-prime repair exonuclease 1 (TREX1) is the major DNase in mammalian cells that degrades cytosolic DNA to prevent activation of cGAS-STING pathway. Genotoxic stress, damage, and radiotherapy induce TREX1 expression cancer cells, allowing them evade innate immune type I interferon (IFN-I)-mediated antitumor response. How can be targeted for immunotherapy remains elusive. Here, we report a high-throughput small-molecule inhibitor (SMI) screen using cell-free assay. We identify two...
<div>Abstract<p>The presence of cancer stem cells (CSC), which possess the ability self-renewal and initiation, is correlated with poor prognosis drug resistance breast patients. But molecular regulatory networks for maintenance CSC function still remain unclear. Here, we identified that an estrogen-inducible gene <i>FXYD3</i>, whose expression significantly upregulated in ER<sup>+</sup> CSCs, a critical player regulating function. FXYD3 amplification...
<p>S1. FXYD3 is required for the maintenance of ER+ cancer stem cells. S2. A) Immunohistochemistry in a tissue microarray (TMA) human breast cancers showed representative examples strong (score 4), moderate 3), weak 2), and negative 1) staining. Scale bar, 100 μm (upper), 20 (lower). B) Bioinformatics analysis public dataset (GEO: GSE75688) expression based on indicated stratifications (unpaired t test, *p<0.05, **p<0.01, ***p<0.001). cancer, N=85; triple-negative (TNBC),...
<p>S1. FXYD3 is required for the maintenance of ER+ cancer stem cells. S2. A) Immunohistochemistry in a tissue microarray (TMA) human breast cancers showed representative examples strong (score 4), moderate 3), weak 2), and negative 1) staining. Scale bar, 100 μm (upper), 20 (lower). B) Bioinformatics analysis public dataset (GEO: GSE75688) expression based on indicated stratifications (unpaired t test, *p<0.05, **p<0.01, ***p<0.001). cancer, N=85; triple-negative (TNBC),...
<div>Abstract<p>The presence of cancer stem cells (CSC), which possess the ability self-renewal and initiation, is correlated with poor prognosis drug resistance breast patients. But molecular regulatory networks for maintenance CSC function still remain unclear. Here, we identified that an estrogen-inducible gene <i>FXYD3</i>, whose expression significantly upregulated in ER<sup>+</sup> CSCs, a critical player regulating function. FXYD3 amplification...
Abstract STING is an endoplasmic reticulum (ER)-associated transmembrane protein that essential for the host innate immune response to pathogens. activated by second messenger cyclic dinucleotides which produced from invading pathogen or DNA sensor cGAS. Activation of triggers its trafficking ER, through ERGIC/Golgi, vesicles, during time activates and quickly terminates downstream interferon signaling. Despite importance signaling in infection, autoimmune disease cancer immunotherapy,...