A5065529900- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Species Distribution and Climate Change
- Plant and animal studies
- Cancer Cells and Metastasis
- Mathematical Biology Tumor Growth
- Immune Cell Function and Interaction
- Evolution and Genetic Dynamics
- Cancer Immunotherapy and Biomarkers
- Remote Sensing in Agriculture
- Pancreatic and Hepatic Oncology Research
- Advanced Image Processing Techniques
- vaccines and immunoinformatics approaches
- Drug-Induced Hepatotoxicity and Protection
- Infectious Disease Case Reports and Treatments
- Phytochemistry and Biological Activities
- Trace Elements in Health
- Nephrotoxicity and Medicinal Plants
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- AI in cancer detection
- Bladder and Urothelial Cancer Treatments
- Biosensors and Analytical Detection
- Liver physiology and pathology
- Influenza Virus Research Studies
Shanghai Jiao Tong University
2019-2025
Cancer immunotherapy has revolutionized cancer treatment, and it relies heavily on the comprehensive understanding of immune landscape tumor microenvironment (TME). Here, we obtain a detailed cell atlas esophageal squamous carcinoma (ESCC) at single-cell resolution. Exhausted T NK cells, regulatory cells (Tregs), alternatively activated macrophages tolerogenic dendritic are dominant in TME. Transcriptional profiling coupled with receptor (TCR) sequencing reveal lineage connections...
<p>Magnetic nanoparticle-mediated hyperthermia (MHT) is a promising tumor theranostic technology due to its noninvasive nature and ability penetrate deep tissues without greatly damaging normal tissues. To advance the clinical translation application of MHT, we present comprehensive overview topics related including basic physical heating principles, magnetic nanoparticle design, biological effects applications. First, fundamental principles through which nanoparticles mediate are...
Adenocarcinoma of the bladder is a rare urinary carcinoma with limited therapy options due to lack molecular characterization. Here, we aimed reveal mutational and transcriptomic landscapes adenocarcinoma assess any relationship prognosis. Between February 2015 June 2021, total 23 patients were enrolled. These included 16 primary adenocarcinomas seven urachal adenocarcinoma. Whole exome sequencing (16 patients), whole genome bulk RNA (RNA-seq) (19 single-cell RNA-seq (5 patients) conducted...
Uncontrolled and excessive progression of liver fibrosis is thought to be the prevalent pathophysiological cause cirrhosis hepatocellular cancer, there are currently no effective antifibrotic therapeutic options available. Intercellular communication cellular heterogeneity in involved fibrosis, but exact nature phenotypic changes patterns interregulatory remain unclear. Here, we performed single-cell RNA sequencing on nonparenchymal cells (NPCs) isolated from normal fibrotic mouse livers. We...
Due to climate change, it is significant explore the impact of rising temperatures on distribution Dendrolimus houi Lajonquiere (Lepidoptera) and its host plants, Pinus yunnanensis Cryptomeria fortunei, simulate their suitable future areas in order provide a theoretical basis for monitoring of, early warning about, D. formulation effective prevention control policies. Based known relevant data for, houi, P. yunnanensis, C. habitat China was predicted using ENMeval package adjust maximum...
Abstract Satyrium is an endangered and rare genus of plant that has various pharmacodynamic functions. In this study, optimized MaxEnt models were used in analyzing potential geographical distributions under current future climatic conditions (the 2050s 2070s) dominant environmental variables influencing their geographic distribution. The results provided reference for implementation long‐term conservation management approaches the species. showed area total suitable habitat ciliatum ( S. )...
Recently deep neutral networks have achieved promising performance for filling large missing regions in image inpainting tasks. They usually adopted the standard convolutional architecture over corrupted image, leading to meaningless contents, such as color discrepancy, blur and artifacts. Moreover, most approaches cannot well handle continuous area cases. To address these problems, we propose a generic framework capable of handling with incomplete images on both discontinuous areas, an...
The aristolochic acids (AAs), derived from Aristolochia and Asarum species used widely in herbal medicines, are closely associated with liver cancer. major AA derivatives acid I (AAI) II (AAII), which can bind DNA covalently to form AA-DNA adducts after metabolic activation vivo. Among all these adducts, 7-(deoxyadenosine-N6-yl) aristolactam (dA-AL-I) is the most abundant persistent lesion patients. However, direct evidence indicating exposure human cancer still missing. Here, we analyzed...
Abstract Tumor clonal structure is closely related to future progression, which has been mainly investigated as mutation abundance clustering in bulk samples. With relatively limited studies at single‐cell resolution, a systematic comparison of the two approaches still lacking. Here, using and mutational data from liver colorectal cancers, we checked whether co‐mutations determined by analysis had corresponding variant allele frequency (VAF) peaks. While suggested absence subclonal peaks...
Although B lymphocytes are widely known to participate in the immune response, conclusive roles of lymphocyte subsets antitumor response have not yet been determined.Single-cell data from GEO datasets were first analyzed, and then a cell flow cytometry panel was used analyze peripheral blood 89 HCC patients 33 healthy controls recruited our research.Patients with had higher frequency B10 cells lower percentage MZB than controls.And changes might occur at an early stage.Moreover, decreased...
Navigation and recognition of disease lesions remain challenging during colorectal cancer diagnosis treatment, given that the precision capacity using specific surface antigens as sites are relatively lacking. Moreover, low penetration rate noninvasive detection methods has delayed in developing countries. We developed a bacterial device targeting Thomsen–Friedenreich antigen, which is abundant on lesion tissue, produced vesicles serve markers for ultrasonic detection. The uses cell display...
ABSTRACT Inspired by fusion-inhibitory peptides from heptad repeat 1 (HR1) and 2 (HR2) domains human immuno-deficiency virus type (HIV-1) envelope glycoprotein gp41 severe acute respiratory syndrome-coronavirus (SARS-CoV) based on viral fusogenic mechanism in the present work, we provided a similar approach to design synthesized against entry into host cells of SARA-CoV-2 that causes 2019 novel coronavirus disease (COVID-19). These derived HR1 HR2 spike protein were further tested for their...
Satyrium is an endangered and rare genus of plant that has various pharmacodynamic functions. In this study, MaxEnt default parameters were adjusted by the ENMeval package. Optimized models used in analyzing potential geographical distributions under current future climatic conditions (the 2050s 2070s) dominant environmental variables influencing their geographic distribution. The results provided reference for implementation long-term conservation management approaches species. showed area...
Abstract Introduction Tumor clonal structure is closely related to future progression, which has been mainly investigated via mutation abundance clustering in bulk sample. With limited studies at single-cell resolution, a systematic comparison of the two approaches still lacking. Methods Here, using and mutational data from liver colorectal cancers, we would like check possibility obtaining accurate tumor structures bulk-level analysis. We checked whether co-mutations determined by analysis...
Abstract Genetic heterogeneity of tumor is closely related to clonal evolution, phenotypic diversity and treatment resistance. Such has been characterized in liver cancer at single-cell sub-chromosomal scale, a more precise single-variant resolution analysis lacking. Here we employed strategy analyze both the genomic mutations transcriptomic changes 5 patients with cancer. Target sequencing was done for total 480 single cells patient-specific manner. DNA copy number status point obtained...
Satyrium is an endangered and rare genus of plant that has various pharmacodynamic functions. The prediction potentially suitable habitat species to analyze their changes, the model MaxEnt niche was applied; furthermore, receiver operating characteristic curve applied accuracy. results provided available reference for implementation long-term conservation management approaches species. Under current climatic conditions, area total ciliatum (S. ciliatum) in China 32.51 × 104 km2, nepalense...