A5059449711- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Bone health and osteoporosis research
- Cancer-related Molecular Pathways
- Advanced Glycation End Products research
- Single-cell and spatial transcriptomics
- Bone Metabolism and Diseases
- Chemokine receptors and signaling
- Venous Thromboembolism Diagnosis and Management
- HIV-related health complications and treatments
- Histone Deacetylase Inhibitors Research
- Blood groups and transfusion
- Animal Virus Infections Studies
- interferon and immune responses
- Platelet Disorders and Treatments
- TGF-β signaling in diseases
- Cancer Cells and Metastasis
- Blood properties and coagulation
- Cell death mechanisms and regulation
- Bone and Joint Diseases
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
Shanghai Jiao Tong University
2014-2025
Tongren Hospital
2017-2025
Northwestern University
2024
Second Hospital of Shandong University
2024
Jinan University
2016-2019
University of Benin
2016
Chinese Academy of Medical Sciences & Peking Union Medical College
1997
Academy of Medical Sciences
1997
Abstract TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. Group innate lymphoid cells (ILC3s) regulate intestinal immunity highly express DR3. Here, we report that activation DR3 signaling by an agonistic anti-DR3 antibody increases GM-CSF production from ILC3s through p38 MAPK pathway. causes accumulation eosinophils, neutrophils CD11b + CD11c myeloid cells, resulting loss intestine IL-23-dependent...
Although many bacteria are tolerant to heavy metals and play important roles in the immobilization of metals, they cannot always be dependably reproduced under field conditions. In this work, a cadmium (Cd)-resistant bacterium was isolated from Cd-contaminated oil identified as Pseudomonas aeruginosa (Pse-w). We then determined various plant growth promoting features such solubilization phosphate, production indole-3-acetic acid siderophores. Lastly, we engineered strain Pse-w-MT by...
Background Long‐term administration of α‐lipoic acid (α‐ LA ) is proved to ameliorate renal impairment. Herein we assessed serum, urinary biomarkers and vascular endothelium function evaluate its short‐period therapeutic effect identify novel for diabetic nephropathy ( DN ). Methods Sixty‐two microalbuminuria‐stage patients were randomly divided into two groups received the following treatment 8 weeks: (1) routine treatment( DM group); (2) with 600 mg/d intravenously group). Another total 21...
Group 2 innate lymphoid cells (ILC2s) manifest tissue heterogeneity and are crucial modulators of regional immune responses. The molecular mechanisms regulating ILC2 properties remain elusive. Here, we interrogate the signatures ILC2s from five tissues at transcriptome epigenetic level. We have found that microenvironment strongly shapes identities. intestine induces Aiolos+ILC2s, whereas lung pancreas enhance Galectin-1+ILC2s. Though being a faithful gut feature under steady state, Aiolos...
Treg cells acquire distinct transcriptional properties to suppress specific inflammatory responses. Transcription characteristics of are regulated by epigenetic modifications, the mechanism which remains obscure. Here, we report that Setd2, a histone H3K36 methyltransferase, is important for survival and suppressive function cells, especially those from intestine. Setd2 supports GATA3+ST2+ intestinal thymic-derived (tTreg) facilitating expression reciprocal relationship GATA3 ST2 in tTreg...
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), which are drugs used for treating type 2 diabetes, have been reported to exert anti-inflammatory effects on inflammatory bowel disease (IBD), the mechanism of remains elusive. Here, we report that GLP-1RAs ameliorate dextran sulfate sodium (DSS)-induced colitis in both wild-type and T/B-cell-deficient mice through modulating group 3 innate lymphoid cells (ILC3s), a subset regulate intestinal immunity. promote IL-22 production by ILC3,...
Emerging epidemiological evidence suggest an association between metabolic syndrome and fractures. However, whether is independent risk or protective factor of fractures remains controversial. Our goal to provide a quantitative assessment the bone by conducting meta-analysis observational studies.The PubMed Embase database were searched through March 2013 identify studies that met pre-established inclusion criteria. Reference lists retrieved articles also reviewed. Summary effect estimates...
Drug resistance constitutes one of the main obstacles for clinical recovery acute myeloid leukemia (AML) patients. Therefore, treatment AML requires new strategies, such as adding a third drug. To address whether GATA2 could act regulator chemotherapy in human cells, we observed KG1a cells and patients' with classic drug (Cerubidine) Gefitinib. After utilizing chemotherapy, expression its target genes (EVI, SCL WT1) surviving were significantly enhanced to double quadrupled compared original...
D-dimer, a soluble degradation product of cross-linked fibrin, is commonly used as an important marker for the diagnosis disseminated intravascular coagulation and differential thrombosis. Herein, we present geriatric case with unusually elevated D-dimer level.An 82-year-old woman, admitted to ward chronic heart failure, was noted have remarkably level, beyond qualified range (> 100 mg/L), utilizing Innovating Sysmex CS-5100 System™. However, no evidence, including clinical symptoms,...
Abstract This study aimed to compare the performance of BD FACSPresto system with conventional standard-of-care technologies for measurement absolute CD4 count (AbsCD4), percentage (CD4%) and total hemoglobin concentration (Hb) in capillary venous blood samples HIV-negative HIV-positive subjects. A 1304 participants were included this prospective cohort study. Both analyzed using results compared against FACSCalibur enumerating AbsCD4 CD4% Sysmex XT-4000i hematology analyzer determining Hb...
Myeloid-derived suppressor cells (MDSCs) occupy a pivotal role in the intricate pathogenesis of autoimmune disorder, Type 1 diabetes mellitus (T1DM). Since our previous work demonstrated that trichosanthin (TCS), an active compound Chinese herb medicine Tian Hua Fen, regulated immune response, we aimed to clarify efficacy and molecular mechanism TCS treatment T1DM. To this end, T1DM mouse model was established by streptozotocin (STZ) induction. The mice were randomly divided into normal...
Psoriasis is a chronic skin disorder characterized by epidermal keratinocyte hyperproliferation and inflammatory infiltration. CCN1 (also termed CYR61 or cysteine-rich angiogenic inducer 61) an extracellular matrix-associated protein that involved in multiple physiological functions. In psoriasis, we recently demonstrated the overexpression of promoted proliferation activation. Furthermore, was highly expressed psoriatic lesions from psoriasis vulgaris patients. Here, dissect underlying...
Purpose: To investigate whether UL43 protein, which is highly conserved in alpha- and gamma herpes viruses, a non-glycosylated transmembrane involved virus entry virus-induced cell fusion.Methods: Mutagenesis was accomplished by markerless two-step Red recombination mutagenesis system implemented on the Herpes simplex 1 (HSV-1) bacterial artificial chromosome (BAC). Growth properties of HSV-1 mutants were analyzed using plaque morphology one-step growth kinetics. SDS-PAGE Western blot...
Nongenetic plasticity has emerged as a key driver of cancer drug resistance, yet its precise origins, nature, and consequences are not fully clarified. This review examines technological, computational, conceptual developments in the nongenetic determinants resistance. We begin by proposing refined definitions cellular state, fate, plasticity. subsequently contextualize findings from multimodal approaches to investigate plasticity, highlighting how new single-cell lineage-tracing methods...
Although B lymphocytes are widely known to participate in the immune response, conclusive roles of lymphocyte subsets antitumor response have not yet been determined.Single-cell data from GEO datasets were first analyzed, and then a cell flow cytometry panel was used analyze peripheral blood 89 HCC patients 33 healthy controls recruited our research.Patients with had higher frequency B10 cells lower percentage MZB than controls.And changes might occur at an early stage.Moreover, decreased...
Objective To investigate the effects of genetic polymorphisms in osteoporosis-related genes and gene-gene interaction on bone mineral density (BMD) osteoporotic fractures.Methods Thirty-nine single nucleotide polymorphism (SNP) sites 23 that related to ( BMD ) fractures were scanned 683 Shanghai Han postmenopausal women.TaqMan SNP Genotyping Assay or Sequenom Mass ARRAY System applied for genotyping analysis.The relation these with analyzed.Results Altogether,12 SNPs 9 candidate rs7524102...