A5027270760- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic and Kidney Cyst Diseases
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Cancer, Lipids, and Metabolism
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Peptidase Inhibition and Analysis
- Gallbladder and Bile Duct Disorders
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Genetic factors in colorectal cancer
- Prion Diseases and Protein Misfolding
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Renal cell carcinoma treatment
- Eosinophilic Disorders and Syndromes
Saga University
2016-2025
Creative Research Enterprises (United States)
2017-2018
Histopathological diagnosis of pancreatic ductal adenocarcinoma (PDAC) on endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB) specimens has become the mainstay preoperative pathological diagnosis. However, EUS-FNB specimens, accurate histopathological evaluation is difficult due to low specimen volume with isolated cancer cells and high contamination blood, inflammatory digestive tract cells. In this study, we performed annotations for training sets by expert pathologists trained...
Tumor budding is a major risk factor for T1 colorectal cancer. Quality control of the pathological diagnosis crucial, irrespective pathologist's experience. This study examines interobserver variability according to pathologists' experience and evaluates influence cytokeratin (CK) immunostaining in assessment budding. Hematoxylin-eosin (HE) CK-immunostained slides 40 cases with primary cancer were examined. Budding grades individually evaluated by 12 pathologists who we categorized into...
Aim Hepatocellular carcinoma ( HCC ) is the second leading cause of cancer mortality worldwide. An excess iron in liver tissue causes oxidative stress, to hepatocellular carcinogenesis. Iron metabolism, which regulated by a complex mechanism, important for cell survival. The aim this study clarify role regulatory protein progression and patient outcome. Methods results We first investigated mRNA level metabolism‐related genes, including hepcidin, ferroportin 1 FPN ‐1) transferrin receptor...
Based on the antibody profiles of inflammatory myositis patients, we investigated type 1 IFN (T1-IFN) signature in serum and DM skin to determine relationship between T1-IFN vasculopathy anti-melanoma differentiation-associated 5 gene (MDA5) antibody-positive patients.We examined 47 patients with new-onset myositis. We divided them into three groups: anti-MDA5 (MDA5 group, n = 16), anti-aminoacyl-tRNA synthetase (aminoacyl-tRNA 12), double-negative (n 19). Serum signatures were revealed by a...
ABSTRACT Background Multiplex genetic testing is recommended when treating nonsmall cell lung cancer. A certain percentage of test failures in RNA assays owing to poor surgical specimen quality have been documented, and fixation failure a possible cause. At our institution, sheet‐like performed reduce time. This study aimed compare the from resected cancer specimens following different methods. Methods Sheet‐like ( n = 15), conventional same lungs other collected for subjected multiplex...
High tumour mutational burden (TMB-high), identified through comprehensive genomic profiling (CGP), is a biomarker that predicts the efficacy of immune checkpoint inhibitors. CGP testing recommended for rare cancers with limited effective treatment options. Here, we provide first report malignant phyllodes breast demonstrating TMB-high status and pembrolizumab. The patient initially underwent right resection was diagnosed tumour. Recurrence observed at same site metastases to pulmonary hilar...
Dendritic cells (DCs) are the most specialized antigen-presenting cells, and lymph nodes (LNs) play an important role in DC-mediated T-cell response. We evaluated infiltration of CD1a-positive DCs (CD1a-DCs), i.e., immature DCs, S100-positive dendritic (S100-DCs), a mixture mature 73 cases laryngeal cancer its regional LNs. Among them, 31 patients underwent radiotherapy (RT) or chemoradiotherapy (CRT) prior to surgery. No significant difference was found for CD1a-DC primary tumors,...
The molecular mechanisms underlying the peritoneal dissemination of gastric cancer remain unclear. Using in vivo metastatic models, this study attempted to clarify role hypoxia inducible factor (HIF)-1α development cancer. HIF-1α knockdown (KD) cells were established scirrhous cell line 58As9. KD and control (SC) cells, presence was assessed orthotopic implantation (o.i.) intraperitoneal injection (i.p.) models. A series vitro analyses also conducted. Finally, tumor angiogenesis...
Solid tumors are often exposed to hypoxia. Hypoxia inducible factor (HIF)-1α upregulates numerous target genes associated with the malignant behavior of hypoxic cancer cells. A member angiopoietin family, angiopoietin-like protein 4 (ANGPTL4) is a hypoxia-inducible gene. The present study aimed clarify whether ANGPTL4 regulated by HIF‑1α in gastric also assessed expression clinicopathological factors or tissues. Hypoxia‑induced was quantitatively analyzed using reverse...
Abstract Background A hypoxic environment often persists within solid tumors, including hepatocellular carcinoma (HCC). Hypoxia-inducible factor-1α (HIF-1α) can accelerate cancer malignancy by inducing hypoxia-dependent expression of various genes. Tumor hypoxia also induce metabolic reprogramming fatty acid (FA) metabolism, through which HIF-1α plays an essential role in diminishing β-oxidation (FAO) cells. Methods We aimed to investigate potential new drug therapy options for targeting...
Among several chemotherapeutic agents, 5-fluorouracil (5-FU) has been widely used as a key drug in adjuvant chemotherapy for gastric cancer. However, no reliable marker, which predicts the response to 5-FU an setting, identified. Hypoxia-induced resistance, via upregulation of HIF-1alpha, is major obstacle development effective cancer therapy. few clinical studies have so far assessed relationship between HIF-1alpha expression and chemo-resistance patients setting. We established 2 knockdown...
Dendritic cells (DCs) are the most specialized antigen-presenting and lymph nodes (LNs) play an important role in DC-mediated T-cell response. We evaluated infiltration of CD1a-positive DCs (CD1a-DCs) i.e. immature DCs, S100-positive dendritic (S100-DCs), a mixture immature- mature 73 cases laryngeal cancer its regional LNs. Among them, 31 patients underwent radiotherapy (RT) or chemoradiotherapy (CRT) prior to surgery. No significant difference was found for CD1a-DC primary tumor,...
Trefoil factor 1 (TFF1) is considered to be a tumor suppressor gene in gastric cancer. However, the role of TFF1 expression and its regulation cancer patients remain unclear. The aims this study were clarify clinical significance determine regulatory mechanisms. We assessed immunohistochemical 182 examined whether or not associated with clinicopathological factors patient survival. In vitro using knockdown cells evaluated invasion. Bisulfite sequencing was performed assess DNA methylation...
A 40‐year‐old Japanese man was admitted to our hospital for evaluation of upper abdominal pain. Abdominal computed tomography (CT) revealed a well‐circumscribed multicystic mass measuring approximately 7 × 6 cm. The contained solid lesion 3 2 Biopsy swollen cervical lymph node led diagnosis diffuse large B‐cell lymphoma. After initial chemotherapy lymphoma, the surgically resected. tumor composed and lesion. Histopathologic examination that locules were lined by biliary epithelium,...
The G-Project committee was erected by the Japan Society for Gastroenterological Carcinogenesis with an aim of establishing a new classification scheme based on molecular biological characteristics that would supplement conventional TNM to better predict outcome.In literature search involving 822 articles gastric cancer, eight molecules including p53, vascular endothelial growth factor (VEGF)-A, VEGF-C, matrix metalloproteinase-7 (MMP-7), human epidermal receptor 2, Regenerating...
<b><i>Background:</i></b> Mammary analogue secretory carcinoma (MASC) of the salivary gland shows morphologic similarities and shares an immunophenotype characteristic <i>ETV6-NTRK3</i> translocation with breast. We present a buccal case MASC along survey-based debate about its cytologic diagnosis by fine-needle aspiration (FNA). <b><i>Case:</i></b> FNA nodule 58-year-old Japanese man was initially performed 3 cytologists who gave...
Clear cell carcinoma (CCC) of the uterine cervix without prenatal diethylstilbestrol exposure is rare, and its etiology unclear. We present a case cervical CCC presenting as submucosal tumor, which strongly suggests an association between endometriosis CCC. A 56-year-old postmenopausal Japanese woman visited gynecologic clinic with complaint watery vaginal discharge. few atypical cells suggesting adenocarcinoma were detected in cytologic specimen. Magnetic resonance imaging revealed cystic...