A5101761882- Inflammatory Bowel Disease
- COVID-19 Clinical Research Studies
- Microscopic Colitis
- SARS-CoV-2 and COVID-19 Research
- Gastrointestinal motility and disorders
- Long-Term Effects of COVID-19
- Bacteriophages and microbial interactions
- Liver Disease Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Pregnancy and Medication Impact
- Cytomegalovirus and herpesvirus research
- COVID-19 and healthcare impacts
- Microbial infections and disease research
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Biosensors and Analytical Detection
- Saffron Plant Research Studies
- Infant Nutrition and Health
- Alzheimer's disease research and treatments
- Animal Virus Infections Studies
- Flavonoids in Medical Research
- Adolescent and Pediatric Healthcare
- Material Properties and Applications
- Metal Forming Simulation Techniques
- Nutritional Studies and Diet
Wuhan University
2023-2025
Renmin Hospital of Wuhan University
2023-2025
The University of Queensland
2024
Southeast University
2023
Henan University
2022
Lanzhou University
2020-2021
First Hospital of Lanzhou University
2020-2021
Army Medical University
2020-2021
Army Medical College
2020
Chinese PLA General Hospital
2020
Abstract The Western diet, characterized by its high content of long-chain fatty acids (LCFAs), is widely recognized as a significant triggering factor for inflammatory bowel disease (IBD). While the link between high-fat diet and colitis has been observed, specific effects mechanisms remain incompletely understood. Our study provides evidence that rich in LCFAs can disrupt integrity intestinal barrier exacerbate experimental mice. Mechanistically, upregulate signal transducer activator...
To investigate the current situation of mental psychology and quality life (QoL) in patients with inflammatory bowel disease (IBD) China, analyze influencing factors.
Background: Most studies have primarily focused on assessing the association between diet or exercise patterns and metabolic dysfunction-associated steatotic liver disease (MASLD). This study adopted a more comprehensive approach by introducing oxidative balance score (OBS) to evaluate combined effects of lifestyle body’s antioxidant ability. Our main objective was investigate OBS burden MASLD in United States. Methods: Participants with complete information from 2001 2018 were included. In...
Iridocyclitis (IC) is a common extraintestinal manifestation of inflammatory bowel disease (IBD). Observational studies showed patients with ulcerative colitis (UC) and Crohn's (CD) both have higher risk IC. However, due to the inherent limitations observational studies, association its directionality between two forms IBD IC remain undiscerned. Genetic variants for were selected as instruments from genome-wide (GWAS) FinnGen database instrumental variables, respectively. A bidirectional...
Objective: To explore the gender differences in psychological symptoms, sleep quality, and quality of life patients with inflammatory bowel disease (IBD). Methods: A unified questionnaire was developed to collect clinical data on psychology IBD from 42 hospitals 22 provinces China September 2021 May 2022. The general characteristics, different genders were analyzed via a descriptive statistical analysis. multivariate logistic regression analysis conducted, independent influencing factors...
Previous observational studies have found that fistulas are common in Crohn's disease (CD) and less ulcerative colitis (UC). However, some patients a fistula before diagnosis. Based on retrospective analysis, it was not possible to determine whether there bi-directional causal relationship between inflammatory bowel (IBD) fistulas.Data were extracted from the open GWAS database; 25,042 cases 34,915 controls included for IBD, 6926 30,228 fistula. Two-sample Mendelian randomization...
Aims This study aimed to evaluate the related research on artificial intelligence (AI) in inflammatory bowel disease (IBD) through bibliometrics analysis and identified basis, current hotspots, future development. Methods The literature was acquired from Web of Science Core Collection (WoSCC) 31 December 2024. Co-occurrence cooperation relationship (cited) authors, institutions, countries, cited journals, references, keywords were carried out CiteSpace 6.1.R6 software Online Analysis...
Despite the exciting progress of bifunctional degrader molecules, also known as proteolysis-targeting chimeras (PROTACs), rapidly expanding field is still significantly hampered by lack available E3 ligase ligands. Our research bridges this gap uncovering a series small-molecule ligands to TRIM21 through DNA-Encoded Library (DEL) technology. We confirmed their interaction with using crystallography and demonstrated antiproliferative effects across various cancer cell types. Furthermore,...
Male novel coronavirus disease (COVID-19) patients tend to have poorer clinical outcomes than female patients, while the myocardial injury is strongly associated with COVID-19-related adverse events. Owing a lack of corresponding data, we aimed investigate sex differences in incidence COVID-19 and identify potential underlying mechanisms, which may partly account for bias This retrospective study included 1,157 who were hospitalized Huoshenshan Hospital from 12 March 2020 11 April 2020. Data...
Staphylococcus aureus is a major human pathogen. Pathogenic effects are largely due to production of bacterial toxins, whose synthesis controlled by an mRNA molecule termed RNAIII. The S. protein called RAP (RNAIII-activating protein) secreted and activates RNAIII inducing the phosphorylation its target TRAP (target RAP). Antibodies have been shown suppress exotoxin in vitro, suggesting that may be useful vaccine site. Here we showed peptide TA21 was identified screening phage display...
Objectives Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are prevalent functional gastrointestinal disorders (FGIDs). In this study we aimed to explore the causal association between physical activity or sedentary behavior risk of FD IBS. Methods Mendelian randomization (MR) analysis was employed. Candidate genetic instruments for were retrieved from latest published Genome‐Wide Association Study (GWAS), which included up 703 901 participants. Summary‐level GWAS data (8 875...
To explore the impact of common gastrointestinal (GI) symptoms on psychological symptoms, sleep quality, and quality life in patients with inflammatory bowel disease (IBD). A unified questionnaire was developed to collect clinical data mental psychology IBD from 42 hospitals 22 provinces P. R. China September 2021 May 2022. The general characteristics, different numbers GI were analyzed by descriptive statistical analysis. total 2,478 finally analysed this study, including 365 without...
Objective We aimed to explore the geographic differences in psychological symptoms, sleep quality, and quality of life (QoL) among adult patients with inflammatory bowel disease (IBD). Methods A unified questionnaire was developed collect data on status QoL IBD from 42 hospitals across 22 provinces, municipalities, autonomous regions China's mainland September 2021 May 2022. Results total 2478 were surveyed. The proportions anxiety (28.5% vs 23.1%), depression (32.3% 27.8%), poor (44.8%...
To the Editor: Cancer, as one of foremost health challenges in world today, has garnered significant attention from medical and scientific communities. As an emerging technology, 3D microfluidic chips have shown great potentials treatment various diseases. Therefore, we aimed to conduct a bibliometric analysis relevant literature on cancer showcasing their current status, hotspots, development trends. We obtained data Web Science Core Collection (WoSCC) accessed by Clarivate Analytics...
Abstract Purpose Inflammatory bowel disease (IBD) patients are usually provided with multiple treatment options different risks and benefits. This study aimed to assess the quality of decision-making in IBD concerning treatments, investigate relationship between Shared (SDM) decision conflict health outcomes IBD, explore possible factors related high decisional IBD. Methods We conducted a cross-sectional, multicenter study. Patients were grouped according their actual role level conflict....