A5100455367- Intracerebral and Subarachnoid Hemorrhage Research
- Mesenchymal stem cell research
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Endoplasmic Reticulum Stress and Disease
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Autophagy in Disease and Therapy
- Corneal Surgery and Treatments
- ATP Synthase and ATPases Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Clusterin in disease pathology
- Lipid metabolism and disorders
- Spinal Cord Injury Research
- Vascular Tumors and Angiosarcomas
- Biochemical effects in animals
- Nerve injury and regeneration
- S100 Proteins and Annexins
- Vascular Malformations Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Macrophage Migration Inhibitory Factor
- Heme Oxygenase-1 and Carbon Monoxide
- Apelin-related biomedical research
First People's Hospital of Yunnan Province
2020-2024
Kunming University of Science and Technology
2020-2024
Fourth Affiliated Hospital of Guangxi Medical University
2024
Second Affiliated Hospital of Zhejiang University
2017-2020
Shanghai Jiao Tong University
2019
Shanghai Ninth People's Hospital
2019
Zhejiang University
2017
Fourth Affiliated Hospital of Anhui Medical University
2017
Anhui Medical University
2017
First Affiliated Hospital of Chinese PLA General Hospital
2013
Neuroinflammation and oxidative stress play important roles in early brain injury following subarachnoid hemorrhage (SAH). This study is the first to show that activation of apelin receptor (APJ) by apelin-13 could reduce endoplasmic reticulum (ER)-stress-associated inflammation after SAH.Apelin-13, siRNA, APJ adenosine monophosphate-activated protein kinase (AMPK) inhibitor-dorsomorphin were used investigate if provide neuroprotective effects SAH. Brain water content, neurological...
Aim: Sirtuin3 (sirt3) plays a pivotal role in improving oxidative stress and mitochondrial dysfunction which directly induced neuronal apoptosis after intracerebral hemorrhage (ICH). Reactive oxygen species (ROS) is also critical activator triggering NACHT, LRR, PYD domains-containing protein 3 (NLRP3) inflammasomes activation can regulate inflammatory responses brain. Moreover, hyperglycemia aggravate the ICH-induced damage. Hence, this study was designed to investigate mechanisms of...
The therapeutic effects of mesenchymal stem cells (MSCs)–material constructs mainly come from the secretion trophic factors MSCs, especially immunomodulatory and angiogenic cytokines. Recent findings indicate significance topographical cues these materials in modulating paracrine functions MSCs. Here, we developed functionalized three-dimensional-printed bioceramic (BC) scaffolds with a mussel-inspired surface coating order to regulate function adipose-derived MSCs (Ad-MSCs). We found that...
Intracerebral hemorrhage (ICH) is a devastating disease with high rates of mortality and morbidity. The aim this study was to explore whether Sodium Benzoate (NaB) could reduce neural cell apoptosis alleviate neurological deficits after ICH. To assess the therapeutic effects NaB, first, we measured brain water content, neurobehavior, blood-brain barrier (BBB) integrity at 24 h ICH in different groups. Then western blot immunofluorescence staining (IF) were applied test levels proteins....
Neuronal apoptosis plays key roles in secondary brain injury caused by intracerebral hemorrhage (ICH). This study first reported the role of mesencephalic astrocyte-derived neurotrophic factor (MANF) alleviating through anti-apoptosis rat model ICH. The recombinant human-MANF(rh-MANF) and selective Akt inhibitor MK2206 was administrated intracerebroventricularly 1h after Brain water content, behavioral assessment, BBB (blood barrier) leakage evaluated 24h induction Western blot analysis used...
This study aimed to explore the neuroprotective effect of mesencephalic astrocyte-derived neurotrophic factor (MANF) protein on early brain injury caused by subarachnoid hemorrhage (SAH) and relevant mechanisms in experimental rats, expecting understand whether MANF was a potential therapeutic target for SAH treatment. A perforation model introduced into study. Recombinant human (rh-MANF) kinase B (Akt) inhibitor (MK2206) were used mechanisms. Multiple approaches systemic assessment employed...
Despite the substantial efforts to elucidate role of early brain injury in subarachnoid hemorrhage (SAH), an effective pharmaceutical therapy for patients with SAH continues be unavailable. This study aims reveal necroptosis after SAH, and explore whether disruption blood-brain barrier (BBB) RIP3-mediated following a rat model are altered by necrostatin-1 via its selective inhibition receptor-interacting protein kinase 1 (RIP1). Sixty-five rats were used experiments. The was established...
Abstract Background Orexins are two neuropeptides (orexin A, OXA; orexin B, OXB) secreted mainly from the lateral hypothalamus, which exert a wide range of physiological effects by activating types receptors receptor 1, OXR1; 2, OXR2). OXA has equal affinity for OXR1 and OXR2, whereas OXB binds preferentially to OXR2. rapidly crosses blood-brain barrier simple diffusion. Many studies have reported OXA’s protective effect on neurological diseases via regulating inflammatory response is also...
Recent findings suggest the feasibility of cardiac repair by transplantation bone marrow mesenchymal stem cell (MSCs). However, it remains controversial regarding which type is best source for transplanting into ischemic heart because lack well-defined markers. In this study, we investigated in vitro and vivo effects novel multipotent cells (MMSCs) from human marrow. Pluripotent markers (Oct4, Bmi1, Abcg2) vascular endothelial growth factor (VEGF) were detected RT-PCR immunofluorescence...
Objective To summarize the research progress of magnetic resonance imaging (MRI) in quantifying liver iron load. Methods current status and MRI technology quantitative study load through reviewing relevant literature at home abroad. Results Different sequence examination techniques have formed a series non-invasive methods for These important clinical significance diagnosis So far, main used to assess are: signal intensity measurement method (signal intensity, SI) [signal ratio (SIR)...
Further treatments are warranted in preventing recurrence or progression for high-grade glioma (HGG) patients having achieved stable disease with tolerable toxicity after the Stupp regimen (6 cycles of temozolomide). This meta-analysis aims to extensively evaluate safety, feasibility, and efficacy long-term therapy temozolomide (>6 cycles) these patients. We systematically searched pubmed, Embase Chinese Biomedical (CBM) databases using strategy combination free-text words MeSH terms. The...
This study aimed to explore the neuroprotective effects and mechanisms of natrium benzoate (NaB) DJ-1 in attenuating reactive oxygen species (ROS)-induced neuronal apoptosis traumatic spinal cord injury (t-SCI) rats. T-SCI was induced by clip compression. The protein expression evaluated Western blotting, double immunofluorescence staining transmission electron microscope (TEM). ROS level, water content (SCWC) Evans blue (EB) extravasation also examined. Locomotor function Basso, Beattie,...
BACKGROUND Mesenchymal stem cells (MSCs) are the leading cellular constituents used in regenerative medicine. MSCs repair and reconstruct wounds of acute traumata radiation-induced burns through proliferation, differentiation, trophic activity. However, effect on severe burn remain to be clarified because much more complex than burns. Survival proliferation microenvironments affected by very important for improving wound repair/regeneration. This study aimed elucidate survival effects...
Apoptosis is a vital pathological factor that accounts for the poor prognosis of traumatic spinal cord injury (t-SCI). The 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) critical regulator energy metabolism and proven to have antiapoptotic effects. This study aimed investigate neuroprotective role PFKFB3 in t-SCI. A compressive clip was introduced establish t-SCI model. Herein, we identified extensively distributed neurons, levels significantly increased peaked 24 h after...
Abstract Aims We aimed to resolve the uncertainty as whether betulin exerted neuroprotection on early brain injury (EBI) caused by subarachnoid hemorrhage (SAH), and investigate related molecular mechanisms. Methods Bioinformatic analysis was performed pre‐study differently expressed genes (DEGs) possible signaling pathways. Rat cellular model of SAH were introduced in this study, betulin, an activator DJ‐1 protein, administered reveal effect. Gross assessment regarding mortality,...
Background Stem cell transplantation represents a promising treatment option for patients suffering from degenerative disorders. Accumulating evidences indicate that mesenchymal stem cells (MSCs) are able to differentiate into retinal pigment epithelial (RPE) -like cells. However, MSCs difficult obtain. Human adipose (ADSCs) proved have similar properties MSCs, but relevant study is less. Objective This was assess the feasibility of human ADSCs differentiating RPE-like and safety its...
Objective To investigate the effect of Salvia miltiorrhiza on in vitro collagen synthesis skeletal muscle-derived stem cells (MDSSs). Methods MDSCs rats were isolated by method adhering to culture plastic different time points.Collagen was induced transforming growt h factor beta-1 (TGF-β1) administration.The effects observed dividing into four groups that cultured under conditions:A,control group; B,150 mg/L C,10 μg/L TGF-β1 D,10 + 150 group.The expressions COL Ⅰ and Smad3 each group...