A5100624057- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- Neurological Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Hepatitis C virus research
- Traditional Chinese Medicine Analysis
- Gastric Cancer Management and Outcomes
- T-cell and B-cell Immunology
- NF-κB Signaling Pathways
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Traditional Chinese Medicine Studies
- Drug Transport and Resistance Mechanisms
- Alzheimer's disease research and treatments
Zhejiang University
2025
Shanghai Changzheng Hospital
2007-2024
University of Science and Technology of China
2021-2024
Second Military Medical University
2011-2024
Weifang Medical University
2021-2024
Chongqing Emergency Medical Center
2022-2023
Chongqing University
2022-2023
Union Hospital
2023
Jilin University
2023
Shaoxing People's Hospital
2022
Background/Aims: Intestinal mucositis (IM) is a commonly encountered side effect in cancer patients receiving chemotherapy. This study aimed to investigate the of Bifidobacterium infantis (B. infantis) attenuating severity chemotherapy-induced intestinal by regulating T cell subsets rats with colorectal (CRC). Methods: Thirty male Sprague-Dawley (SD) were injected dimethyl hydrazine (DMH) subcutaneously for 10 weeks, and then SW480 cells rectal mucosa create CRC model, randomly divided into...
The Notch signaling pathway is involved in determination of cell fate and control proliferation multiple organ systems. Jag1 encodes a ligand the has been identified as disease-causing gene for developmental disorder Alagille syndrome. Evidence from study human disease mouse models implicated having an important role development bile ducts. We have derived conditional knockout allele ( loxP) to liver duct development. crossed loxP mice with transgenic line carrying Cre recombinase under...
Adequate bowel preparation is important for colonoscopy. Currently available evidence on the determinants of poor largely derived from studies in Western countries. We aimed to identify risk factors inadequate colonoscopy Chinese population.In this single-center study, patients admitted Outpatient Department between March 2013 and December 2015 had indications were prospectively enrolled. Questionnaires administered patients. Their characteristics procedure-related parameters such as...
Abstract Background Mutations in methylmalonyl-CoA mutase cause methylmalonic acidemia, a common organic aciduria. Current treatment regimens rely on dietary management and, severely affected patients, liver or combined liver-kidney transplantation. For undetermined reasons, transplantation does not correct the biochemical phenotype. Methods To study metabolic disturbances seen this disorder, we have created murine model with null allele at locus and correlated results observed knock-out...
Several studies have investigated the effect of intraoperative blood loss (IBL) on recurrence tumors. However, independent IBL oncological outcome after liver transplantation (LT) for hepatocellular carcinoma (HCC) is unclear.A total 479 patients who underwent LT HCC from January 2001 to December 2012 at our institution were enrolled in this retrospective study. Kaplan-Meier and Cox regression methods used assess rate, as well its risk factors. Stratified analysis was performed further...
Recently, aberrantly high levels of D-ribose have been discovered in type II diabetic patients. glycates proteins more rapidly than D-glucose, resulting the production advanced glycation end products (AGEs). Accumulations these can be found impaired renal function, but mechanisms are poorly understood. The present study tested whether induces dysfunction via RAGE-dependent NF-κB signaling pathway. In vivo, administration was to lower blood glucose and regulate insulin tolerance. Compared...
Despite sustained effort, the prognosis of lung cancer remains poor and therapeutic responses are limited. Cell movement ability is a prerequisite for metastasis, which involves focal adhesion kinase (FAK)‑mediated cell migration invasion via complex formation with Src. Hence, FAK‑Src signaling might be an effective target anti‑cancer treatment. β‑elemene, major component elemene extracted from Curcuma Rhizoma, exhibits broad‑spectrum anti‑tumor properties. However, role β‑elemene in...
Background Cellular senescence plays an irreplaceable role in tumorigenesis, progression, and tumor microenvironment (TME) remodeling. However, to date, there is limited research delineating the landscape of cellular hepatocellular carcinoma (HCC), improved understanding on interaction tumor-associated with HCC prognosis, TME, response immunotherapy warrant. Methods Tumorigenic immune infiltration-associated genes were determined by weighted gene co-expression network analysis (WGCNA)...
Lung adenocarcinoma is one of the most frequent tumor subtypes, involving changes in a variety oncogenes and suppressor genes. Hydroxysteroid 17-Beta Dehydrogenase 6 (HSD17B6) could synthetize dihydrotestosterone, abnormal levels which are associated with progression multiple tumors. Previously, we showed that HSD17B6 inhibits malignant hepatocellular carcinoma. However, mechanisms underlying inhibiting development by not clear. Moreover, its role lung (LUAD) yet unknown. Here, investigated...