A5100318511- Mechanical stress and fatigue analysis
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Tribology and Lubrication Engineering
- Gear and Bearing Dynamics Analysis
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Gut microbiota and health
- Cell Adhesion Molecules Research
- Axon Guidance and Neuronal Signaling
- Fibroblast Growth Factor Research
- Proteoglycans and glycosaminoglycans research
- Cancer, Hypoxia, and Metabolism
- Curcumin's Biomedical Applications
- Radiation Therapy and Dosimetry
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Epigenetics and DNA Methylation
- Colorectal and Anal Carcinomas
- Lymphoma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Tribology and Wear Analysis
Dalian University of Technology
2022-2024
Anhui Medical University
2024
Anhui Provincial Hospital
2024
University of Science and Technology of China
2020-2023
Cancer poses a serious threat to human health and is the most common cause of death. Polymer-based nanomedicines are presently used enhance treatment effectiveness decrease systemic toxicity chemotherapeutic agents. However, disadvantage currently polymeric carriers without therapy procedure. Herein, for first time, glutathione (GSH)-responsive polymer (PRES) with anti-cancer effect was synthesized following condensation-polymerization method using resveratrol (RES) 3,3'-dithiodipropionic...
The efficacy of chemotherapeutic agents for colon cancer treatment is limited by multidrug resistance (MDR) and insufficient intracellular release the administered nanomedicine. To overcome these limitations, we constructed a pH/ROS cascade-responsive self-accelerating drug nanoparticle system (PLP-NPs) multidrug-resistant cancer. PLP-NPs comprised reactive oxygen species (ROS)-sensitive polymeric paclitaxel (PTX) prodrug (DEX-TK-PTX), pH-sensitive poly(l-histidine) (PHis), beta-lapachone...
Abstract Background The erythropoietin-producing hepatocellular (Eph) receptor A5 (EphA5) has been found to be overexpressed in some malignant tumors and is associated with disease prognosis. However, the role of EphA5 esophageal squamous cell carcinoma (ESCC) not clear. Methods In present study, we measured expression ESCC tissues lines including KYSE150 KYSE450 cells. siRNA transfection was used interfere lines. Cell viability, colony formation, scratch invasion assays were performed...
Despite sustained effort, the prognosis of lung cancer remains poor and therapeutic responses are limited. Cell movement ability is a prerequisite for metastasis, which involves focal adhesion kinase (FAK)‑mediated cell migration invasion via complex formation with Src. Hence, FAK‑Src signaling might be an effective target anti‑cancer treatment. β‑elemene, major component elemene extracted from Curcuma Rhizoma, exhibits broad‑spectrum anti‑tumor properties. However, role β‑elemene in...
Colorectal cancer is a commonly diagnosed and the leading cause of cancer-related death which still increasing in many countries. The lack biomarkers for early detection clinic treatment results high morbidity mortality. novel role long noncoding RNA LINC00857 on cell proliferation migration invasion was explored this article. expression level colorectal tissue samples cells determined notably higher than normal cells. Silence can significantly inhibit viability metastasis vitro. Moreover,...
We investigated the expression and biological function of retinoic acid inducible gene I (RIG-I) in esophageal squamous cell carcinoma (ESCC). Materials methods: An immunohistochemical analysis was performed on 86 pairs tumor tissue adjacent normal samples patients with ESCC. generated RIG-I-overexpressing ESCC lines KYSE70 KYSE450, RIG-I- knockdown KYSE150 KYSE510. Cell viability, migration invasion, radioresistance, DNA damage, cycle were evaluated using CCK-8, wound-healing transwell...
BackgroundMAGEA1, a member of the melanoma antigen family, undergoes intracellular proteasomal processing for presentation by MHC class I molecules on cell surface, thereby mediating immune responses. However, its biological role in non-small lung cancer (NSCLC) has remained elusive.MethodsBioinformatics analysis was employed to scrutinize MAGEA1 expression disparities between tissues and normal tissues. Cells were transfected with overexpression or downregulation vectors, proliferation,...
Background: Extranodal natural killer/T-cell lymphoma (ENKTCL) has a unique treatment principle. However, the optimal combination of drugs along with radiotherapy (RT) is unknown. Design: Retrospective cohort study. Objectives: We screened multiple drug combinations to identify most efficacious therapeutic combinations. Methods: reviewed 3105 patients who received 40 chemotherapy regimens different 9 classes and/or RT. Least absolute shrinkage and selection operator multivariable Cox...
<div>Abstract<p>Commensal bacteria are crucial to maintain immune homeostasis in mucosal tissues and disturbances their ecology can affect disease susceptibility. Here, we report evidence that commensal shape the efficiency of surveillance tissues. Antibiotic-treated (Abt) mice were more susceptible development engrafted B16/F10 melanoma Lewis lung carcinoma, exhibiting a shortened mean survival time with numerous larger tumor foci lungs. The defective antitumor response Abt was...
<div>Abstract<p>Commensal bacteria are crucial to maintain immune homeostasis in mucosal tissues and disturbances their ecology can affect disease susceptibility. Here, we report evidence that commensal shape the efficiency of surveillance tissues. Antibiotic-treated (Abt) mice were more susceptible development engrafted B16/F10 melanoma Lewis lung carcinoma, exhibiting a shortened mean survival time with numerous larger tumor foci lungs. The defective antitumor response Abt was...