A5102880949- Liver physiology and pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Heart Rate Variability and Autonomic Control
- Liver Disease Diagnosis and Treatment
- Medicinal Plant Pharmacodynamics Research
- Drug Transport and Resistance Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Radiomics and Machine Learning in Medical Imaging
- Functional Brain Connectivity Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Monoclonal and Polyclonal Antibodies Research
- Sphingolipid Metabolism and Signaling
- Renal cell carcinoma treatment
- Cardiovascular and exercise physiology
- Fungal Biology and Applications
- Trigeminal Neuralgia and Treatments
- Advanced Neuroimaging Techniques and Applications
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- Chemical Synthesis and Analysis
- Urinary Bladder and Prostate Research
- Brain Metastases and Treatment
- Cancer therapeutics and mechanisms
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
Changchun University of Chinese Medicine
2023
Jinan Maternity And Care Hospital
2020-2022
Capital Medical University
2021-2022
Anhui Provincial Hospital
2018-2021
University of Science and Technology of China
2018-2020
China Medical University
2017-2020
Shaanxi University of Chinese Medicine
2017-2018
The histological grade of pancreatic cancer is an important independent predictor outcome. However, we lack a method for safely and accurately obtaining the pathological before surgery. Radiomics has been used to discriminate between grades in tumors. We aimed develop validate radiomics signature preoperative prediction ductal adenocarcinoma (PDAC) that was based on contrast-enhanced computed tomography (CE-CT).This study comprised 301 patients with pathologically confirmed PDAC who were...
The efficacy of chemotherapeutic agents for colon cancer treatment is limited by multidrug resistance (MDR) and insufficient intracellular release the administered nanomedicine. To overcome these limitations, we constructed a pH/ROS cascade-responsive self-accelerating drug nanoparticle system (PLP-NPs) multidrug-resistant cancer. PLP-NPs comprised reactive oxygen species (ROS)-sensitive polymeric paclitaxel (PTX) prodrug (DEX-TK-PTX), pH-sensitive poly(l-histidine) (PHis), beta-lapachone...
Angipoietin‐1 (Angpt1) and von Willebrand factor (VWF) are two important angiogenic molecules that can drive pathologic angiogenesis progression of liver fibrosis in our previous study. MicroRNAs (miRs) participate a variety physiological pathological processes, including angiogenesis. However, the critical miRs targeting Angpt1 or VWF potential molecular mechanism underlying fibrosis–associated is not clear yet. Human tissues were obtained from patients with different chronic diseases....
Patients with classic trigeminal neuralgia (CTN) have abnormalities in white matter integrity of the corpus callosum (CC). However, CTN patients, it is unclear whether CC substructure region affected to varying degrees.A total 22 patients and healthy controls (HC) matching age, gender, education were selected. All subjects underwent 3.0 T magnetic resonance diffusion tensor imaging high resolution T1-weighted imaging. The was reconstructed by DTI technology, which divided into three regions:...
The dopamine D4 receptor (DRD4) promoter (-616; rs747302) has been associated with primary nocturnal enuresis (PNE); however, its relationship neuroimaging not investigated. Therefore, we assessed the effects of DRD4 -616 C/G single nucleotide polymorphism on gray matter volume (GMV) and functional connectivity density (FCD) during resting-state magnetic resonance imaging in children PNE using voxel-based morphometry FCD methods. Genomic data were obtained from 97 105 healthy controls. was...
IQ motif-containing guanosine triphosphatase (GTPase)-activating protein 1 (IQGAP1) is a cytosolic scaffolding involved in cell migration. Our previous studies suggest sphingosine 1-phosphate (S1P) triggers bone marrow (BM) mesenchymal stromal cells (BMSCs) to damaged liver, thereby promoting liver fibrosis. However, the role of IQGAP1 S1P-induced BMSC migration and fibrogenesis remains unclear. Chimeric mice BM labeled by EGFP were used build methionine-choline-deficient high-fat...
Human epidermal growth factor receptor (EGFR) has been established as a therapeutic target of lung cancer and other diverse tumors. The antibody drug Cetuximab developed to the third subdomain III (TSDIII) EGFR extracellular domain (ECD) by competitively inhibiting binding. In this study, we performed systematic investigation on crystal complex structure ECD with create residue importance profile for TSDIII subdomain, based which number U-shaped, double-stranded linear peptides were derived...
ABSTRACT Introduction: Chronic obstructive pulmonary disease (COPD) is a type of inflammatory respiratory system characterized by chronic airflow limitation. Aerobic exercise training believed to influence the drug treatment this positively. Objective: Study impact complementary aerobic intervention on pharmacological in patients with COPD. Methods: In controlled experiment, 40 volunteers under for COPD were selected and equally divided into two groups. The experimental group was treated...
Objective: The study is intended to explore the anti-tumor effect of rhizoma curcumae in treatment gastric cancer.Methods: Kunming mice grafted with a mouse adenocarcinoma cell line MFC was used as experimental model.The were divided into four groups, one control and other three different drug administration groups.The assessed by tumor size, apoptotic indices (AI) expression VEGF, STAT3 HIF-1α tissues.Results: Compared controls, size weigh significantly inhibited decoction (P<0.05).AI...
To verify the anti-tumor effect of Shenfoweikang on gastric cancer, BALB/C mice grafted with a mouse adenocarcinoma cell line MFC was used as experimental model.The received herbs over 60-day period starting at first day.The tumor size periodically measured.Apoptotic indices (AI) were examined by TUNEL method and flow cytometric analysis.The expression VEGF, STAT3 DEC1 in tissues immunostaining.Compared control group, growth treated decoction significantly inhibited (P<0.05).AI increased...
Objective To preliminary investigate the clinical efficacy of whole brain simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) in patients diagnosed with metastases (BM). Methods Fifty-two cases BM admitted to our hospital from January 2016 December 2017 were equally recruited and randomly divided into observation control groups. Patients group treated SIB-IMRT, those received conventional (WBRT). The prognosis statistically compared between two...