Lung cancer has long been the most dangerous malignant tumor among males in both well developed and poorly countries. Radiotherapy plays a critical role curative management of inoperable non-small cell lung (NSCLC) is also used as post-surgical treatment patients. Radioresistance an important factor that limits efficacy radiotherapy for NSCLC Increasing evidence suggests microRNAs (miRNAs) possess diverse cellular regulatory roles radiation responses. In this study, we miRNA microarray...

Objective LRPPRC is a newly discovered N 6 -methyladenosine (m A) modification reader, which potentially affects hepatocellular carcinoma (HCC) progression. PD-L1 in tumor cells essential for immune evasion. This work investigated the LRPPRC-mediated m A-modification effect on mRNA and escape HCC. Methods Expression clinical implication of were measured human HCC cohorts. The influence malignant behaviors was through vitro assays xenograft murine models. posttranscriptional mechanism...

Resistance to first-line chemotherapy drugs has become an obstacle improving the clinical prognosis of patients with small cell lung cancer (SCLC). Exosomal microRNAs have been shown play pro- and anti-chemoresistant roles in various cancers, but their role SCLC chemoresistance never explored. In this study, we observed that expression exosomal miR-92b-3p was significantly increased who developed chemoresistance. Luciferase reporter analysis confirmed PTEN a target gene miR-92b-3p. The...

Lung cancer is the most common cause of cancer-related mortality worldwide, and nonsmall cell lung (NSCLC) accounts for 80% all pulmonary carcinomas. Recently, long noncoding RNAs (lncRNAs) have been paid attention exploring treatment various diseases. Upregulation DiGeorge syndrome critical region gene 5 (DGCR5) predicts better squamous carcinoma prognosis; therefore, we explore role DGCR5 in our present study. Consecutive patients with LC were treated hospital between January 2015 2016....

Abstract Background Chemoresistance is one of the major obstacles for tumor treatment. Circular RNAs (circRNAs) have been confirmed to play vital roles in chemoresistance cancer, including esophageal squamous cell carcinoma (ESCC). We investigated and mechanisms circ_0007142 cisplatin (DDP) resistance ESCC. Methods Quantitative real‐time polymerase chain reaction (qRT‐PCR) was conducted determine levels circ_0007142, DOCK1 mRNA, microRNA‐494‐3p (miR‐494‐3p) LIM And SH3 Protein 1 (LASP1)...

Esophageal squamous cell carcinoma (ESCC) is a common type of malignant cancer. There growing evidence suggesting that exosomes may participate in the cellular communication tumor-associated fibroblasts (TAFs). However, cisplatin resistance TAF-derived to ESCC cells remains be further studied. Exosomes were isolated from TAFs and characterized with Western blot TEM assays. lines (TE-1 KYSE-150) incubated TAFs-derived exosomes. To explore biological function proliferation, apoptosis,...

Abstract N 6 ‐methyladenosine (m A) modification represents the most abundant internal methylation of eukaryotic RNAs. KIAA1429 acts as a key component m A methyltransferase complex, but its function and mechanism in ferroptotic cell death hepatocellular carcinoma (HCC) are barely defined. We found that suppression triggered ferroptosis HCC cells according to increased death, iron MDA levels, C11‐BODIPY‐positive cells, ROS production decreased GSH level. Ferroptosis inhibitors ferrostatin‐1...

Our aim was to develop dual-modal CNN models based on combining conventional ultrasound (US) images and shear-wave elastography (SWE) of peritumoral region improve prediction breast cancer.We retrospectively collected US SWE data 1271 ACR- BIRADS 4 lesions from 1116 female patients (mean age ± standard deviation, 45.40 9.65 years). The were divided into three subgroups the maximum diameter (MD): ≤15 mm; >15 mm ≤25 >25 mm. We recorded lesion stiffness (SWV1) 5-point average tissue (SWV5)....

Cisplatin‑based chemotherapy may greatly enhance patient prognosis; however, resistance remains an obstacle to curing patients with non‑small cell lung cancer (NSCLC). The aim of the present study was explore microRNAs (miRs) that could regulate cisplatin sensitivity and provide a potential treatment method for in clinical. Results from revealed miR‑29a overexpression enhanced inhibition reduced two NSCLC lines, A549 H1650, treatment. In addition, expression levels were observed...

Colorectal cancer is a commonly diagnosed and the leading cause of cancer-related death which still increasing in many countries. The lack biomarkers for early detection clinic treatment results high morbidity mortality. novel role long noncoding RNA LINC00857 on cell proliferation migration invasion was explored this article. expression level colorectal tissue samples cells determined notably higher than normal cells. Silence can significantly inhibit viability metastasis vitro. Moreover,...

Abstract Lung cancer (LC) is the leading cause of cancer‐related death worldwide. Recent studies have shown that tripartite motif 13 (TRIM13) play important regulatory roles in progression different tumors. In this study, we focused on role TRIM13 LC tumorigenesis and its underlying molecular mechanisms. The study demonstrated was identified as a novel tumor suppressor gene overexpression suppressed vitro vivo. Mechanistically, interacted with RPS27A, increasing RPS27A ubiquitination...

Objective: To explore the effect and safety of avatrombopag for chemotherapy-induced thrombocytopenia (CIT). Methods: This multicenter, open-label, single-arm trial enrolled CIT patients in eight centers from October 2020 to April 2021. The participants received tablets 60 mg once a day 5-10 days. main endpoint was proportion with platelet count ≥100×109/L or increased by ≥ 50×109/L 100% cycle after start treatment. Results: Seventy-four were mean age 59.8 ± 11.62.2% males. cumulative...

The aim of the present study was to investigate association between single-nucleotide polymorphisms (SNPs) in X-ray repair cross-complementing 1-399 (XRCC1-399) or excision cross-complementation group 1-118 (ERCC1-118) and short-term efficacy radiochemotherapy, tumor metastasis relapse, as well survival time patients with esophageal squamous cell carcinoma (ESCC). TaqMan probe-based quantitative polymerase chain reaction (qPCR) conducted examine levels XRCC1-399 ERCC1-118 SNPs peripheral...

Objectives Proanthocyanidins (PAs) have been widely used as effective agents for dentin collagen cross-linking to enhance the biomechanics and biostability of in vitro. However, effects protective mechanisms various tea root-derived PA components on remain undefined. This study evaluated these biostability. Methods In this study, ethyl acetate n-butyl alcohol were extract PAs with different degrees polymerization from roots; extracts evaluated. Results Dentin was treated glutaraldehyde,...

We investigated the expression and biological function of retinoic acid inducible gene I (RIG-I) in esophageal squamous cell carcinoma (ESCC). Materials methods: An immunohistochemical analysis was performed on 86 pairs tumor tissue adjacent normal samples patients with ESCC. generated RIG-I-overexpressing ESCC lines KYSE70 KYSE450, RIG-I- knockdown KYSE150 KYSE510. Cell viability, migration invasion, radioresistance, DNA damage, cycle were evaluated using CCK-8, wound-healing transwell...

Cellular senescence, a state of stable growth arrest, is intertwined with human cancers. However, characterization cellular senescence-associated phenotypes in hepatocellular carcinoma (HCC) remains unexplored.To address this issue, we delineated senescence landscape across HCC.We enrolled two HCC datasets, TCGA-LIHC and International Cancer Genome Consortium (ICGC). Unsupervised clustering was executed to probe tumor heterogeneity based upon genes. Least absolute shrinkage selection...

Type 2 diabetes (T2DM), one of the most prevalent chronic diseases, affects glucose metabolism human body, which decreases quantity life and brings a heavy burden on social medical care. Patients with T2DM are more likely to suffer bone fragility fracture as mineral density (BMD). However, discovery determinant factors BMD in way is expensive time-consuming. In this paper, we propose novel algorithm, Prior-Knowledge-driven local Causal structure Learning (PKCL), discover underlying causal...

Background: Hepatocellular carcinoma (HCC) is one of the most malignant tumors. The in vitro experiments on application Anhydroicaritin (AHI), active ingredient Bushen Huayu Decoction, HCC treatment remain limited, particularly regarding its molecular mechanism. Methods: TCMSP platform was used for drug screening. GeneCards database and DisGeNET are to collect liver cancer targets. PPI network construction component-target intersection target completed with string database. GO KEGG pathway...

Conventional ultrasound diagnosis of thyroid nodules (TNs) had a high false-positive rate, resulting in many unnecessary fine-needle aspirations (FNAs).This study aimed to establish simple algorithm reduce FNA on TIRADS 4 TNs using different quantitative parameters ultrasonic elasticity and chi-square automatic interactive detector (CHAID) method.From January 2020 May 2021, 432 were included the study, which confirmed by or surgical pathology. Each TN was examined conventional ultrasound,...