Multilevel upper airway surgery is effective for some patients with obstructive sleep apnea (OSA), but prediction the response to remains a challenge. The underlying endotypes of OSA include collapsibility, muscle compensation, loop gain, and arousal threshold. This study aimed explore effect on polysomnography (PSG)-derived establish surgical model. Our included 54 Chinese who underwent multilevel surgery. Participants PSG before after median follow-up time 6.5 months. Using...

This study will start from the current background of government policies and administration higher vocational education development in Hebei Province thoroughly investigate main problems affecting reform Province. By introducing Taoist thought, it effectively improves many deficiencies educational Vocational Technical Colleges, which is not only conducive to improving internal level service quality colleges, but also creating a more harmonious efficient learning environment for teachers...

Piezocatalyst-enabled sonopiezoelectric therapy offers noninvasive treatment with high spatiotemporal selectivity, yet existing piezocatalysts are limited by suboptimal efficacy, cancer cell resistance to oxidative stress, and biosafety concerns. Here, hafnia (HfO2), one of the only few FDA-approved inorganic nanomaterials for clinical trials, is identified as a promising piezocatalyst translational potential enzymatic PANoptosis-boosted nanocatalytic therapy. Specifically, engineered...

To evaluate the prevalence, characteristics, and respiratory arousal threshold (ArTH) of Chinese patients with positional obstructive sleep apnea (POSA) according to Cartwright Classification (CC) Amsterdam Positional Obstructive Sleep Apnea (APOC).A large-scale cross-sectional study was conducted in our center from 2007 2018 analyze clinical polysomnography (PSG) data POSA patients. Low ArTH defined based on PSG indices.Of 5,748 OSA patients, 36.80% met CC criteria, 42.88% APOC for POSA....

Abstract Background Few studies have been reported regarding the accuracy of 3D-printed models for orthodontic applications. The aim this study was to assess dental different tooth surfaces. Methods Thirty volunteers were recruited from hospital, and then their produced by means oral scanning a stereolithography-based 3D printer. Each printed model digitally scanned compared with oral-scanned STL file via superimposition analysis. A color map used surfaces (occlusal, buccal, lingual)...

Angiogenesis involves the activation of endothelial cells followed by capillary formation. Leptin, protein product ob gene, can induce angiogenic potential cells. However, underlying cellular mechanism still remains to be elicited. We firstly evaluated in vitro effects leptin on proliferation and differentiation cell line EA.hy926. Leptin was found potently induced proliferation, expression migration tube Then we investigated roles Akt Wnt signaling pathways aforementioned processes. It...

In our large-scale study, the correlation between obstructive sleep apnea (OSA) related to rapid eye movement (REM) and cardiac autonomic dysfunction was assessed by standard polysomnography (PSG). Cardiac evaluated measurement of heart rate variability (HRV). The cardiovascular disease (CVD) risk determined using cross-sectional prevalence CVD its overall 10 year according Framingham score (FRS). 4152 individuals were included in study. A higher apnea-hypopnea index during REM (AHIREM )...

We explored whether a new combination of eye mask sleep position therapy (SPT) and oral appliance (OAT) was more effective at treating positional obstructive apnea (POSA) than the use either device alone.In this randomized controlled trial, 60 POSA subjects diagnosed by standard polysomnography (PSG) were divided into three groups (ratio 1:1:1): SPT, OAT, SPT combined with OAT (SOT). Participants underwent hospital-based follow-ups during months 1 6 after beginning treatment. The primary...

We investigated the associations between multiple sleep dimensions in obstructive apnea (OSA) and carotid intima-media thickness (CIMT), an early sign of atherosclerosis, participants from Shanghai Sleep Health Study.

Patients with cartilage damage have various discomforts, including pain, clicks, deformities, and dysfunction. Chondrocytes are a crucial component of restoration; however, their limited proliferative ability degenerative specificity dramatically reduce effectiveness. In the present study, effects leptin on chondrocyte proliferation, chondrogenic secretion marker gene expression, matrix were evaluated in vitro. The roles mitogen-activated protein kinase (MAPK) B (AKT) signaling pathways...

The aim of this study was to evaluate anterior teeth movement with different archwire planes and sizes during space closure without miniscrew in sliding mechanics.

Objectives Proanthocyanidins (PAs) have been widely used as effective agents for dentin collagen cross-linking to enhance the biomechanics and biostability of in vitro. However, effects protective mechanisms various tea root-derived PA components on remain undefined. This study evaluated these biostability. Methods In this study, ethyl acetate n-butyl alcohol were extract PAs with different degrees polymerization from roots; extracts evaluated. Results Dentin was treated glutaraldehyde,...

Slow-wave sleep (SWS) and obstructive apnea (OSA) have attracted recent research attention. However, their joint effects on insulin resistance (IR) remain unclear. This study explored whether SWS influences the relationship between OSA IR.We enrolled potential participants in our center from 2007 to 2019. We collected demographic clinical characteristics determined IR status. was derived polysomnography data. Logistic regression analysis used reveal associations IR.In all, 6966 (5709 1257...

Fibroblast growth factor 21 (FGF21) is a metabolic regulator and potential biomarker of diseases. Limited data are available on the association between FGF21 obstructive sleep apnea (OSA), which considered as manifestation syndrome. In present cross-sectional longitudinal analyses, level was associated with OSA. This analysis two clinical cohorts first to show that increased significantly OSA severity an independent predictor incident in Chinese adults. The circulating could serve serum its...

Patients with chronic rhinosinusitis nasal polyps (CRSwNP) have a higher risk of obstructive sleep apnea (OSA). However, the relationship between CRSwNP and OSA remains unclear. The aim this research study was to evaluate association multiple single nucleotide polymorphism (SNP) variations in sleep- breath-related parameters men OSA.We included eight SNPs 2320 participants after strict screening. For each participant, genetic score (GRS) calculated based on cumulative effect variants CRSwNP....

ABSTRACT Objectives To investigate the effects of transpalatal (TPA) wire dimension and temporary skeletal anchorage device (TSAD) position on maxillary molar intrusion. Materials Methods The intrusion measurement system included a acrylic model, TPA, TSADs, three-dimensional Force/Moment (F/M) sensor. patterns were categorized into six groups: buccal-mesial, buccal-distal, buccal-mesiodistal, palatal-mesial, palatal-distal, palatal-mesiodistal. TPA dimensions designed to be 0.7 mm, 0.9 1.2...

Objective To measure the palatal soft tissue thickness and cortical bone density to determine safe regions for placement of orthodontic mini-implants examine influence sex age on density. Materials methods Cone-beam computed tomography images 42 patients (22 males 20 females), including 21 adults adolescents, were examined in this study. The measured at coronal planes between premolars (P4–5), second first molars (P5–6), (P6–7). Results revealed similar planes, but varied. mean was 3.8 mm...

Transient stability and critical clearing time (CCT) are important concepts in power system protection control. This paper explores compares various learning-based methods for predicting CCT under uncertainties arising from renewable generation, loads, contingencies. Specially, we introduce new definitions of transient (B-stablilty) an engineering perspective. For training the models, only initial values variables contingency cases used as features, enabling provision information based on...