A5107956979- biodegradable polymer synthesis and properties
- Advanced biosensing and bioanalysis techniques
- Biofuel production and bioconversion
- Microplastics and Plastic Pollution
- RNA modifications and cancer
- Polymer crystallization and properties
- Carbon dioxide utilization in catalysis
- Phytochemicals and Antioxidant Activities
- Polymer composites and self-healing
- DNA and Nucleic Acid Chemistry
- Nanoplatforms for cancer theranostics
- RNA and protein synthesis mechanisms
- Catalysis for Biomass Conversion
- Fermentation and Sensory Analysis
- Enzyme Catalysis and Immobilization
- Supercapacitor Materials and Fabrication
- Galectins and Cancer Biology
- Enzyme Production and Characterization
- Ubiquitin and proteasome pathways
- Polymer Nanocomposites and Properties
- Innovative concrete reinforcement materials
- Gout, Hyperuricemia, Uric Acid
- Advanced oxidation water treatment
- Enzyme Structure and Function
- Nanoparticle-Based Drug Delivery
Shanghai Jiao Tong University
2019-2025
First Affiliated Hospital of Wenzhou Medical University
2025
Wenzhou Medical University
2025
Shanxi Medical University
2025
University of South China
2025
Hangzhou Normal University
2024
Tsinghua University
2024
Boston University
2024
Northeastern University
2024
Lund University
2024
Senescence of bone marrow mesenchymal stem cells (BMMSCs) induced by chronic oxidative stress is an important factor contributes to the postmenopausal osteoporosis (PMOP). Mitochondrial quality control takes a pivotal role in regulating and cell senescence. Genistein major isoflavone soy products, which best known for its ability inhibit loss both women ovariectomized (OVX) rodents. Here we show that OVX-BMMSCs displayed premature senescence, elevated reactive oxygen species (ROS) level...
Abstract Ionic skin (I‐Skin) has the advantage of feasible compatibility with biological systems. Nevertheless, developing a stable and durable ionic is challenging. Here, an polyurethane (i‐PU) synthesized, which capable self‐healing able to lock liquids (ILs). In detail, chain extender containing ammonium cationic group followed by polymerization obtain target i‐PU. Through electrostatic interaction diffusion, i‐PU can be fully self‐healed at room temperature within 400 min. Afterward, low...
The C–F bond is the strongest covalent single (126 kcal/mol) in carbon-centered bonds, which highest electronegativity of fluorine (χ = 4) gives rise to shortest length (1.38 Å) and smallest van der Waals radius (rw 1.47 Å), resulting enormous challenges for activation transformation. Herein, conversion was realized via photouranium-catalyzed hydroxylation unactivated aryl fluorides using water as a hydroxyl source deliver multifunctional phenols under ambient conditions. featured cascade...
The very slow degradation of biodegradable polymers in the marine environment is due to lack dedicated enzymes open seas. As a result, introducing monomers that have fast hydrolysis process required accelerate seawater degradation. Poly(butylene succinate-co-glycolate) (PBSGA) copolyesters with glycolic acid (GA) units ranging from 5 40% were synthesized by our newly developed polymerizing method based on oligo(glycolic acid). results 1H-NMR and GPC revealed short GA segments evenly...
Diffusion models have recently demonstrated an impressive ability to address inverse problems in unsupervised manner. While existing methods primarily focus on modifying the posterior sampling process, potential of forward process remains largely unexplored. In this work, we propose Shortcut Sampling for Diffusion(SSD), a novel approach solving zero-shot Instead initiating from random noise, core concept SSD is find specific transitional state that bridges measurement image y and restored x....
The aim of the present study was to screen novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from Macadamia integrifolia antimicrobial protein 2 (MiAMP2) and evaluate potential antidiabetic targets involved signaling pathways using in silico approaches. In digestion MiAMP2 with pepsin, trypsin chymotrypsin performed ExPASy PeptideCutter generated were subjected BIOPEP-UWM, iDrug, INNOVAGEN Autodock Vina for further analyses. Six EQVR, EQVK, AESE, EEDNK, EECK, EVEE predicted possess...
This project was designed to explore the xanthine oxidase (XO) inhibitory mechanism of eight structurally diverse phenolic compounds [quercetin: C1, quercetin-3-rhamnoside: C2, 4, 5-O-dicaffeoylquinic acid: C3, 3, C4, 4-O-di-caffeoylquinic C5, 4-O-caffeoylquinic acid (C6), 3-O-caffeoylquinic C7, and caffeic C8]. For this purpose, in-vitro different computational methods were applied determine potential compounds. The results revealed that (C1-C8) possess strong weak XO activity. These...
Aliphatic-aromatic copolyesters offer a promising solution to mitigate plastic pollution, but high content of aliphatic units (>40 %) often suffer from diminished comprehensive performances. Poly(butylene oxalate-co-furandicarboxylate) (PBOF) were synthesized by precisely controlling the oxalic acid 10 % 60 %. Compared with commercial PBAT, barrier properties PBOF for H
Juvenile myelomonocytic leukemia (JMML) is an invasive myeloproliferative neoplasm and a childhood disease with very high clinical lethality. The SHP2 encoded by the PTPN11 gene, which nonreceptor (pY)-phosphatase mutation causes JMML. structural hierarchy of includes protein tyrosine phosphatase domain (PTP) Src-homology 2 (N-SH2 C-SH2). Somatic (E76Q) in interface SH2-PTP most commonly identified found up to 35% patients mechanism this mutant associated JMML poorly understood. Here,...
The 2,5-furandicarboxylic acid (FDCA)-based aliphatic–aromatic copolyester is an intensively researched area of bio-based polymers with high gas barrier and mechanical properties. However, the contradiction between degradation performance still remains a huge challenge severely limits their applications. Here, we combine branched neopentyl glycol, hydrophilic diglycolic acid, FDCA to prepare poly(neopentyl glycol diglycolate/furandicarboxylate) (PNDF) copolyesters. With poor crystallization...
Hepatitis C virus (HCV) is a notorious member of the Flaviviridae family enveloped, positive-strand RNA viruses. Non-structural protein 5A (NS5A) plays key role in HCV replication and assembly. NS5A multi-domain which includes an N-terminal amphipathic membrane anchoring alpha helix, highly structured domain-1, two intrinsically disordered domains 2-3. The domain-1 contains zinc finger (Zf)-site, binding stabilizes overall structure, while ejection this from Zf-site destabilizes structure....
Recombination reactions often occur in the process of chemical, thermal, or mechanical degradation vulcanized styrene butadiene rubber (SBR), which hinders recycling efficiency waste tire rubbers. In this work, we developed an effective method to transform solid SBR into reclaimed with 100% sol fraction through a hydrogen peroxide (H2O2)-induced thermo-oxidative reclamation at 100 °C assistance soybean oil. The structural evolution and role H2O2 oil reclaiming were investigated by sol–gel...
2,5-Thiophenedicarboxylic acid (TDCA) is a biobased building block for aromatic–aliphatic copolyesters. This study synthesized poly(propylene succinate-co-thiophenedicarboxylate) (PPSTh) and adipate-co-thiophenedicarboxylate) (PPATh) via two-step melt polycondensation. PPATh70 exhibits the highest melting temperature at 144.8 °C. Crystallization kinetics indicate that diol-TDCA segments primarily form crystalline phases in PPXThs, with long aliphatic units enhancing crystallization. PPXThs...