A5101441458- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Nanoplatforms for cancer theranostics
- Bone Tissue Engineering Materials
- Vascular Malformations Diagnosis and Treatment
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- Retinal Diseases and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Plant Molecular Biology Research
- Cancer Genomics and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Osteoarthritis Treatment and Mechanisms
- Plant Reproductive Biology
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
- Retinal Development and Disorders
- Chemical Synthesis and Analysis
- Enzyme Production and Characterization
- Glaucoma and retinal disorders
- PI3K/AKT/mTOR signaling in cancer
- Electrochemical sensors and biosensors
- Plant Gene Expression Analysis
Simcere Pharmaceutical (China)
2021-2025
Guangzhou Medical University
2022-2024
Chinese Academy of Sciences
2018-2024
Hunan Provincial Maternal and Child Health Hospital
2024
Gannan Medical University
2024
Shanghai Institute of Ceramics
2018-2024
Zhejiang University
2008-2024
University of Chinese Academy of Sciences
2018-2024
Sichuan Academy of Agricultural Sciences
2021-2024
Zhengzhou University
2024
Osteoarthritis not only results in cartilage lesion, but also is accompanied with subchondral bone damage caused by the inflammatory response. It of great significance to treat osteoarthritis regulating immune As copper (Cu) plays an essential role response and anti-arthritis, a copper-incorporated bioactive glass-ceramics (Cu-BGC) may achieve aim healing lesion reducing osteoarthritis. We hypothesized that Cu2+ released from Cu-BGC scaffolds satisfy requirements regeneration anti-arthritis....
A multifunctional Nd-Ca-Si biomaterial is designed for fluorescence thermometry, photothermal therapy, and burn tissue repair.
Ras undergoes interconversion between the active GTP-bound state and inactive GDP-bound state. This GTPase cycle, which controls activities of Ras, is accelerated by GTPase-activating proteins (GAPs) guanine nucleotide exchange factors (SOS). Oncogenic mutations could affect cycle impair functions. Additionally, Src-induced K-Ras Y32/64 dual phosphorylation has been reported to disrupt hinder downstream signaling. However, underlying mechanisms remain unclear. To address this, we performed...
Poorly healing and nonhealing diabetic wounds are challenging to treat as the rapid growth of bacteria due high local glucose content can lead persistent inflammation poor angiogenesis. Herein, a smart hydrogel dressing composed 3,3',5,5'-tetramethylbenzidine/ferrous ion/Pluronic F-127/glucose oxidase (TMB/Fe2+/PF127/GOx) is designed demonstrated consume blood while accelerating wound by generating antibacterial agents in situ. The loaded GOx degrades provide hydrogen peroxide (H2O2)...
Abstract Immune checkpoint inhibitors (ICIs) have become prominent therapies for gastrointestinal cancer (GC). However, it is urgent to screen patients who can benefit from ICIs. Protein patched homolog 1 (PTCH1) a frequently altered gene in GC. We attempt explore the association between PTCH1 mutation and immunotherapy efficacy. The Memorial Sloan Kettering Cancer Center (MSKCC) cohort (n = 236) with GC (esophageal, gastric colorectal cancers) receiving ICIs was used discovery Peking...
Hydrogels may be the ideal vitreous substitutes due to their wonderful physical features and biocompatibility. However, drawbacks, short residence time, biodegradation in vivo, have led fact that none of them been approved for clinical use. In this study, we developed a novel approach using foldable capsular body (FCVB) injected with polyvinylalcohol (PVA) hydrogel as substitute long-term tamponade. The 3% PVA was cross-linked by gamma irradiation showed good rheological properties had no...
For the postoperative treatment of bone cancer, biomaterials should possess an antitumor effect and simultaneous repair ability defects. Compared with single photothermal or magnetothermal treatment, photo/magnetothermal joint represents a more high-efficient strategy to kill tumor cells. In this work, 3D-printed bioceramic scaffold was successfully designed fabricated, which exhibited function killing cells excellent osteogenic bioactivity, via incorporating Fe element into akermanite (AKT)...
Biodegradable blends of poly(butylene adipate-co-terephthalate) (PBAT) and stereocomplex polylactide (sc-PLA) were prepared herein via a melt blending method at various sc-PLA loadings. Wide-angle X-ray diffraction differential scanning calorimetry results verified that complete crystallites in the PBAT could be achieved. Scanning electron microscopy observation indicated was dispersed matrix as spherical particles; size did not display pronounced increase once content sc-crystallites...
CRISPR-Cas systems are prokaryotic adaptive immunity against invading phages and plasmids. Phages have evolved diverse protein inhibitors of systems, called anti-CRISPR (Acr) proteins, to neutralize this CRISPR machinery. In response, bacteria co-evolved Cas variants escape phage's strategies, anti-anti-CRISPR systems. Here we explore the allosteric inhibition rescue mechanisms between Streptococcus thermophilus Cas9 (St1Cas9) AcrIIA6 at atomic level, by generating mutants key residues in...
A worldwide epidemic of obesity and its associated metabolic disorders raise the significance adipocytes, their origins characteristics. Our previous study has demonstrated that interscapular brown adipose tissue (BAT), but not intramuscular adipose, is derived from Pax3-expressing cell lineage. Here, we show various depots subcutaneous (SAT) visceral (VAT) are highly heterogeneous in Pax3 lineage origin. Interestingly, relative abundance cells SAT inversely correlated to expression BAT...
When osteochondral tissues suffer from focal or degenerative lesions caused by trauma disorders, it is a tough challenge to regenerate them because of the limited self-healing capacity articular cartilage. In this study, series Mo-doped bioactive glass ceramic (Mo-BGC) scaffolds were prepared and then systematically characterized. The released MoO42- ions 7.5Mo-BGC played vital role in regenerating cartilage subchondral bone synchronously. Methods: Mo-BGC fabricated through employing both...
Natural products from marine actinomycetes remain an important resource for drug discovery, many of which are produced by the genus, Streptomyces. However, in standard laboratory conditions, specific gene clusters microbes have long been considered silent or covert. Thus, various stress techniques activated latent leading to isolation potential metabolites. This study focused on analysis two new angucycline antibiotics isolated culture filtrate a