A5027904931- Corporate Governance and Management
- Auditing, Earnings Management, Governance
- Corporate Finance and Governance
- Auction Theory and Applications
- Experimental Behavioral Economics Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Law and Political Science
- Flexible and Reconfigurable Manufacturing Systems
- Accounting and Organizational Management
- Virus-based gene therapy research
- Law, Economics, and Judicial Systems
- Financial Markets and Investment Strategies
- European Monetary and Fiscal Policies
- Transgenic Plants and Applications
- Public Administration and Political Analysis
- Banking stability, regulation, efficiency
- Financial Reporting and Valuation Research
- Digitalization, Law, and Regulation
- Medical and Health Sciences Research
- Corporate Governance and Law
- Economic Policies and Impacts
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Corporate Taxation and Avoidance
- Global Financial Regulation and Crises
Ludwig-Maximilians-Universität München
2014-2024
Catholic University of Eichstätt-Ingolstadt
2024
Fraunhofer Institute for Electronic Nano Systems
2024
Munich Business School
2013-2023
National University of Singapore
2012-2023
University of California, Los Angeles
2015-2023
LMU Klinikum
2011-2023
Clemenshospital Münster
2021-2023
University of Bayreuth
2016-2023
University of Hagen
2014-2021
Viral vectors are the most efficient tools for gene delivery, and search tissue-specific infecting viruses is important development of in vivo therapy strategies. The baculovirus Autographa californica nuclear polyhedrosis virus widely used as a vector expression foreign genes insect cells, its host specificity supposed to be restricted arthropods. Here we demonstrate that recombinant A. efficiently taken up by human hepatocytes via an endosomal pathway. High-level reporter from heterologous...
Phytochelatin (PC) synthesis has been well demonstrated as a major metal tolerance mechanism in Arabidopsis thaliana, whereas its contribution to long-distance element transport especially monocots remains elusive. Using rice cereal model, we examined physiological roles of Oryza sativa phytochelatin synthase 1 (OsPCS1) the distribution and detoxification arsenic (As) cadmium (Cd), two toxic elements associated with food safety concerns. First, isolated four different transcript variants...
Studies of two SARS-CoV-2 mRNA vaccines suggested that they yield ∼95% protection from symptomatic infection at least short-term, but important clinical questions remain. It is unclear how vaccine-induced antibody levels quantitatively compare to the wide spectrum induced by natural infection. Vaccine response kinetics and magnitudes in persons with prior COVID-19 compared virus-naı̈ve are not well-defined. The relative stability versus infection-induced unclear. We addressed these issues...
Gene therapy of liver diseases requires the development efficient vectors for gene transfer in vivo. Retroviral and adenoviral have been shown to deliver genes efficiently into hepatocytes vitro However, these do not allow exclusive infection which would be highly advantageous vivo strategies. We recently demonstrated that genetically modified baculoviruses (Autographa californica nuclear polyhedrosis virus) cultured cells a strong preference different origin. Baculoviral transduction...
Baculovirus vectors are able to transduce a large variety of mammalian cell types and express transgenes placed under the control heterologous promoters. In this study, we evaluated potential baculovirus for malaria vaccination. To induce efficient CD4(+) CD8(+) T-cell responses, produced series that display Plasmodium falciparum circumsporozoite (CS) protein in virion envelope and/or allow CS expression upon transduction cells. We found can professional antigen-presenting cells trigger...
ABSTRACT Recombinant human adenoviruses (hAd) have become widely used as tools to achieve efficient gene transfer. However, successful application of hAd-derived vectors in clinical trials is limited due immunological and potential safety problems inherent their origin. In this study, we describe a recombinant ovine adenovirus (OAV) an alternative vector for transfer vivo. contrast hAd vector, the OAV was not neutralized by sera. An which contained cDNA α 1 -antitrypsin (hAAT) linked Rous...
Phytochelatin (PC) synthesis is essential for the detoxification of non-essential metals such as cadmium (Cd). In vitro experiments with Arabidopsis thaliana seedlings had indicated a contribution to zinc (Zn) tolerance well. We addressed physiological role PC in Zn homeostasis plants under more natural conditions. Growth responses, accumulation and leaf ionomes wild-type AtPCS1 mutant cultivated different soils representing adequate supply, deficiency excess were analyzed. on...
CD8
In this paper, we describe the identification and characterization of two novel essential mitotic spindle proteins, Duo1p Dam1p. was isolated because its overexpression caused defects in mitosis a arrest. localized by immunofluorescence, immunoelectron microscopy, tagging with green fluorescent protein (GFP), to intranuclear microtubules pole bodies. Temperature-sensitive duo1 mutants arrest short spindles. This is dependent on checkpoint. Dam1p identified two-hybrid analysis as that binds...
Abstract We model relative performance evaluation ( RPE ) when a Chief Executive Officer CEO has the power to opportunistically influence design of by choosing weight on an index‐based peer group or customizing selection peers comprising group. A powerful compares benefits reducing common risk affecting his compensation with receiving higher bonus economizing expected peer‐group performance. As consequence, Board Directors (BoD) is less likely use . Our analytical yields hypotheses...
ABSTRACT: This study uses principal-agent analysis to investigate how the principal's use of performance measures in agent's compensation contract are affected by (1) links between and (2) substitute complementary characteristics an efforts. We show that directional effect changes measure interrelations on linear incentive weights depends tasks interact with each other (i.e., or interactions). For example, increases do not necessarily imply higher more sensitive precise measures. If efforts...