A5068763099- Hepatocellular Carcinoma Treatment and Prognosis
- Heat shock proteins research
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- thermodynamics and calorimetric analyses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Vector-borne infectious diseases
- Fibroblast Growth Factor Research
- Clinical Reasoning and Diagnostic Skills
- Spectroscopy Techniques in Biomedical and Chemical Research
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
- Perfectionism, Procrastination, Anxiety Studies
- Bee Products Chemical Analysis
- Effects of Radiation Exposure
- Lanthanide and Transition Metal Complexes
- Empathy and Medical Education
- Diversity and Career in Medicine
- Endoplasmic Reticulum Stress and Disease
- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- Mentoring and Academic Development
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
LMU Klinikum
2023-2025
Ludwig-Maximilians-Universität München
2021-2025
Klinikum rechts der Isar
2019-2023
Technical University of Munich
2019-2023
München Klinik
2023
Hadassah Medical Center
2023
Society of Interventional Radiology
2023
American College
2023
In contrast to normal cells, tumor cells of multiple entities overexpress the Heat shock protein 70 (Hsp70) not only in cytosol, but also present it on their plasma membrane a tumor-specific manner. Furthermore, Hsp70-positive actively release Hsp70 small extracellular vesicles with biophysical characteristics exosomes. Due conformational changes lipid environment, most commercially available antibodies fail detect membrane-bound and vesicular Hsp70. To fill this gap assess role circulation...
PurposeTo assess immunogenic effects in unembolized contralateral tumor after single lobar yttrium-90 transarterial radioembolization (90Y-TARE) of colorectal liver metastases (CRLMs).Material and MethodsThe analysis comprised 10 patients with microsatellite stable (MSS) CRLM scheduled for staged treatment the prospective AROMA trial. Eligibility criteria included bilobar metastatic disease >5 lesions without any within 3 weeks. Baseline biopsy was followed by initial 90Y-TARE 1 lobe, a...
Prognostic biomarkers identifying patients with early tumor progression after local ablative therapy remain an unmet clinical need. The aim of this study was to investigate circulating miR-21 and miR-210 levels as prognostic HCC treated by CT-guided high-dose rate brachytherapy (HDR-BT).24 consecutive (BCLC A B) HDR-BT (1 × 15 Gy) were included in prospective IRB-approved study. RT-PCR performed quantify blood samples acquired prior 2 d HDR-BT. Follow-up imaging (contrast-enhanced liver MRI...
Image-guided radiofrequency ablation (RFA) is used to treat focal tumors in the liver and other organs. Despite potential advantages over surgery, hepatic RFA can promote local distant tumor growth by activating pro-tumorigenic factor cytokines. Thus, strategies identify suppress pro-oncogenic effects of are urgently required further improve therapeutic effect. Here, proliferative effect plasma Hepatocellular carcinoma or colorectal patients 90 min post-RFA was tested on HCC cell lines,...
Abstract Hyperthermia is a form of cancer treatment which frequently applied in combination with radiotherapy (RT) to improve therapy responses and radiosensitivity. The mode action hyperthermia multifactorial; the one hand by altering amount blood circulation treated tissue, on other modulating molecular pathways involved cell survival processes immunogenic interactions. One most dominant proteins induced major stress‐inducible heat shock protein 70 (Hsp70). Hsp70 can be found either as...
The concentration of circulating heat shock protein 70 (Hsp70) was measured in liquid biopsies canine tumor patients as a potential biomarker. Compared with rodent models, spontaneously occurring tumors pet dogs reflect the clinical situation human better, cohabitate their owners same environment, reach much older age than rodents, can provide blood samples more frequently, and receive up-to-date medical care and, similar to humans, show high genetic heterogeneity. Due species-specific...
Objective: Space for personality development as well the of critical, creative and interdisciplinary thinking is rarely found in medical curricula Germany. To be prepared challenges modern medicine, future physicians need a visionary mindset. The aim this study to determine teaching such content among students context elective examine these with regard desired topics organizational structure. Methods: This cross-sectional 236 from all semesters Ludwig-Maximilians-University Munich. survey...
Circulating Hsp70 levels were determined in feline and porcine cohorts using two different ELISA systems. These comparative animal models of larger organisms often reflect diseases, especially malignant tumors, better than conventional rodent models. It is therefore essential to investigate the biology utility tumor biomarkers animals such as cats pigs. In this study, free blood with spontaneously occurring tumors detected a commercial (R&D Systems). Sub-analysis groups revealed that...
To determine the potential prognostic value of proliferation and angiogenesis plasma proteins following CT-guided high dose rate brachytherapy (HDR-BT) hepatocellular carcinoma (HCC).
Abstract Purpose The role of microRNA-146a (miR-146a) in defining the tumor immune microenvironment (TIME) is well established. aim this study was to evaluate circulating miR-146a as an early prognostic marker 90 Y-radioembolization ( Y-RE) metastatic liver cancer and assess correlation between TIME cellular composition distant, yet untreated metastases. Methods Twenty-one patients with bilobar lesions from gastro-intestinal underwent lobar Y-RE. Biopsy contralateral lobe abscopal tumors...
Abstract Background Mentoring is important for a successful career in academic medicine. In online matching processes, profile texts are decisive the mentor-selection. We aimed to qualitatively characterize mentoring-profile-texts, identify differences form and content thus elements that promote selection. Methods mixed method study first, quality of 150 selected mentoring profiles was evaluated (10-point Likert scale; 1 = insufficient 10 very good). Second, based on thematic analysis...
Local ablative therapies are established treatment modalities in the of early- and intermediate-stage hepatocellular carcinoma (HCC). Systemic effects local ablation on circulating immune cells may contribute to patients' response. Depending their activation, myeloid able trigger HCC progression as well support anti-tumor immunity. Certain priming monocytes already occur while still circulation. By using flow cytometry, we analyzed peripheral blood monocyte cell populations from a...
Zielsetzung Untersuchung von Serum-miR-21- und miR-210 als prognostische Biomarker bei mit CT-gesteuerter Hochdosis-Brachytherapie (HDR-BT) behandeltem HCC.
In contrast to normal cells, tumor cells of multiple entities overexpress the Heat Shock Protein 70 (Hsp70) not only in cytosol, but also present it on their plasma membrane a tumor-specific manner. Furthermore, membrane-Hsp70 positive actively release Hsp70 into lipid microvesicles termed exosomes blood. Due conformational changes environment, most commercially available antibodies fail detect membrane-bound and exosomal Hsp70. To fill this gap assess role circulation as potential...