A5037442051- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Heart Rate Variability and Autonomic Control
- Nutrition and Health in Aging
- Frailty in Older Adults
- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Heart rate and cardiovascular health
- Health and Medical Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Failure Treatment and Management
- Food Allergy and Anaphylaxis Research
- Cardiac electrophysiology and arrhythmias
- Vagus Nerve Stimulation Research
- Technology Use by Older Adults
- GDF15 and Related Biomarkers
- Renal function and acid-base balance
- Cardiac Health and Mental Health
- Biomedical and Chemical Research
- Hemodynamic Monitoring and Therapy
- Blood Pressure and Hypertension Studies
- Contact Dermatitis and Allergies
- Pressure Ulcer Prevention and Management
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Arrest and Resuscitation
Humboldt-Universität zu Berlin
2018-2025
Charité - Universitätsmedizin Berlin
2016-2025
Freie Universität Berlin
2018-2025
Martin Luther University Halle-Wittenberg
2007-2025
Evangelische Hochschule Berlin
2015-2025
Berliner Hochschule für Technik
2024
Weatherford College
2020
Franklin University
2020
Gesundheitsdienst
2019
GTx (United States)
2017
Objective: Multiple organ dysfunction syndrome (MODS) is the sequential failure of several systems after a trigger event, like sepsis or cardiogenic shock. Mortality rate high, up to 70%. Autonomic may substantially contribute development MODS. Our study aimed characterize a) spectrum autonomic critically ill MODS patients; b) whether different in patients receiving sedation, mechanical ventilation, catecholamines; c) age dependency MODS; and d) predicts mortality Design: Prospective cohort...
Intravenous immunoglobulin as an adjunctive treatment in sepsis was regarded promising by a Cochrane meta-analysis of smaller trials. In this phase III multicenter trial, we assessed whether intravenous G (ivIgG) reduced 28-day mortality and improved morbidity patients with score-defined severe sepsis.Randomized, double-blind, placebo-controlled, trial.Twenty-three medical surgical intensive care units university centers large teaching hospitals.Patients (n = 653) (sepsis score 12-27)...
Abstract Immersive Virtual Reality (VR) with head-mounted displays (HMD) can be a promising tool for increasing adherence to exercise in older adults. However, there is little known about the effectiveness of an interactive multimodal therapy VR chronic back pain (CBP) patients. The aim exploratory randomized controlled trial was examine preliminary adults CBP laboratory setting over period four weeks. intervention group (IG; n = 11) received (movement and psychoeducation) control (CG;...
Inflammatory pathways are involved in the development of atherosclerosis. Interaction vessel wall cells and invading monocytes by cytokines may trigger local inflammatory processes. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) standard medications used cardiovascular diseases. They thought to have anti-inflammatory capacities, addition their lipid-lowering effects. We investigated effect statins cytokine-mediated-interaction-model human vascular smooth muscle (SMC)...
Various gait parameters can be used to assess the risk of falling in older adults. However, state-of-the-art systems quantify often come with high costs as well training and space requirements. Gait analysis systems, which use mobile commercially available cameras, an easily available, marker-free alternative. In a study 44 participants (age ≥ 65 years), patterns were analyzed three different systems: pressure sensitive walkway system (GAITRite-System, GS) gold standard, Motognosis Labs...
To determine the safety and efficacy of aerobic exercise on activities daily living in subacute phase after stroke.Multicentre, randomised controlled, endpoint blinded trial.Seven inpatient rehabilitation sites Germany (2013-17).200 adults with stroke (days 5-45 stroke) a median National Institutes Health scale (NIHSS, range 0-42 points, higher values indicating more severe strokes) score 8 (interquartile 5-12) were randomly assigned (1:1) to physical fitness training (n=105) or relaxation...
Abstract Background Frailty is expressed by a reduction in physical capacity, mobility, muscle strength, and endurance. (Pre-)frailty present up to 42% of the older surgical population, with an increased risk for peri- postoperative complications. Consequently, these patients often suffer from delayed or limited recovery, loss autonomy quality life, decrease functional cognitive capacities. Since frailty modifiable, prehabilitation may improve physiological reserves reduce care dependency 12...
Abstract Linked to exacerbated inflammation, myocarditis is a cardiovascular disease, which may lead dilated cardiomyopathy. Although sex and age differences in the development of chronic have been postulated, underlying cellular mechanisms remain poorly understood. In current study, we aimed investigate mitochondrial homeostasis, senescence. Cardiac tissue samples from younger older patients with inflammatory cardiomyopathy (DCMI) were used. The expression Sirt1, phosphorylated AMPK,...
Zusammenfassung Die zentrale Bedeutung der Muskelmasse, -kraft und -funktion im Alter ist eindeutig wissenschaftlich belegt. Frage, wie sich eine Adipositas auf die Kraft Funktion Skelettmuskulatur auswirkt, wurde jedoch lange Zeit kaum systematisch untersucht. Diese Arbeit gibt Übersicht über Kohortenstudien zum Zusammenhang von mit Muskelkraft diskutiert zugrundeliegende Ursachen Fettinfiltration, subklinische Inflammation mitochondriale Dysfunktion. zeigen, dass trotz Zunahme des...
Recent findings support the view that bioenergetic part of septic organ failure is not caused by insufficient supply oxygen but disturbances mitochondrial function. Therefore, aim present study was to investigate key enzymes energy metabolism in hearts answer question whether or impairment glycolytic occur under these conditions. For this purpose well established model baboons used. Baboons general anesthesia were made infusion Escherichia coli. Single challenge with high amounts bacteria...
Objective: In chronic heart failure (CHF) the myocardial expression of inflammatory cytokine tumor necrosis factor alpha (TNF-α), which is thought to contribute remodeling, was found be increased. However, it unknown whether E3-ubiquitin ligases MAFbx and Murf-1 are involved in this remodeling process their regulated by TNF-α. Methods: Rats underwent ligation left coronary artery induce CHF or were sham-operated. The MAFbx/Murf-1 troponin I analyzed RT-PCR Western blotting non-infarcted area...
LPSs trigger the development of sepsis by gram-negative bacteria and cause a variety biological effects on host cells, including alterations ionic channels. Because heart rate variability is reduced in human endotoxemia, we hypothesized that LPS affects pacemaker current If heart, which might-at least part-explain this phenomenon. Isolated myocytes from right atrial appendages were incubated for 6 to 10 h with (1 μg/mL) afterwards used investigate If. was measured whole-cell patch-clamp...
sarcopenia is common especially in hospitalised older populations. The aim of this study was to assess the prevalence sarcopenia, defined as low skeletal mass and muscle strength, its impact on 1-year mortality patients with cancer.skeletal estimated using bioelectric impedance analysis related height2 (SMI; Janssen et al. 2002). Grip strength measured JAMAR dynamometer cut-offs suggested by European Working Group Sarcopenia Older People (EWGSOP) were applied. One-year assessed telephone...
Abstract Background Today immersive environments such as Virtual Reality (VR) offer new opportunities for serious gaming in exercise therapy and psychoeducation. Chronic back pain (CBP) patients could benefit from exergames VR. The requirements older CBP a VR have not yet been determined studies. aim of the study was to perform analysis user group geriatric with exergame. objective find out expectations, desires, preferences barriers order collect them this vulnerable determine frameworks by...
Hip fractures are a major public health problem with increasing relevance in aging societies. They associated high mortality rates, morbidity, and loss of independence. The aim the EMAAge study was to determine impact hip on patient-reported health-related quality life (HRQOL), identify potential risk factors for worse outcomes.EMAAge is multicenter, prospective cohort patients who suffered fracture. Patients or, if necessary, proxies were interviewed after initial treatment six months using...