A5051163305- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
- Balkans: History, Politics, Society
- Memory, Trauma, and Commemoration
- Cultural Heritage Management and Preservation
- Proteoglycans and glycosaminoglycans research
- Fatty Acid Research and Health
- Bone and Dental Protein Studies
- Cancer Cells and Metastasis
German Cancer Research Center
2020-2021
Heidelberg University
2020-2021
Toronto Metropolitan University
2021
Abstract HER3 is highly expressed in luminal breast cancer subtypes. Its activation by NRG1 promotes of AKT and ERK1/2, contributing to tumour progression therapy resistance. HER3-targeting agents that block this activation, are currently under phase 1/2 clinical studies, although they have shown favorable tolerability, their activity as a single agent has proven be limited. Here we show phosphorylation cells occurs paracrine manner mediated cancer-associated fibroblasts (CAFs). Moreover,...
Abstract HER3 is highly expressed in luminal breast cancer subtypes. Its activation by NRG1 promotes of AKT and ERK1/2, contributing to tumour progression therapy resistance. HER3-targeting agents that block this activation, are currently under phase 1/2 clinical studies, although they have shown favorable tolerability, their activity as a single agent has proven be limited. Here we show phosphorylation cells occurs paracrine manner mediated cancer-associated fibroblasts (CAFs). Moreover,...
The formation of national memory depends to a large extent on nation’s success in constructing multiple commemorative forms: symbols, ceremonies and celebrations, museums monuments, tradition, cultural texts that provide symbolic arenas for narrating the nation. These forms assist tracing themes continuity between past present; they establish shared history heritage. Significant changes life, whether social political, later collective mind its citizens. With political landscapes changing,...
The formation of national memory depends to a large extent on nation’s success in constructing multiple commemorative forms: symbols, ceremonies and celebrations, museums monuments, tradition, cultural texts that provide symbolic arenas for narrating the nation. These forms assist tracing themes continuity between past present; they establish shared history heritage. Significant changes life, whether social political, later collective mind its citizens. With political landscapes changing,...