A5043368288- Mycotoxins in Agriculture and Food
- Folate and B Vitamins Research
- Pesticide Residue Analysis and Safety
- Metabolism and Genetic Disorders
- Fermentation and Sensory Analysis
- Metabolomics and Mass Spectrometry Studies
- Wheat and Barley Genetics and Pathology
- Plant and fungal interactions
- Meat and Animal Product Quality
- Insect and Pesticide Research
- Plant Toxicity and Pharmacological Properties
- Nutritional Studies and Diet
- Plant Pathogens and Fungal Diseases
- Fungal Plant Pathogen Control
- Phytochemicals and Antioxidant Activities
- Nutrition, Genetics, and Disease
- Fluoride Effects and Removal
- Amino Acid Enzymes and Metabolism
- Horticultural and Viticultural Research
- Analytical Chemistry and Chromatography
- Advanced Glycation End Products research
- Fatty Acid Research and Health
- Biochemical Analysis and Sensing Techniques
- Diet and metabolism studies
- Advanced Chemical Sensor Technologies
Technical University of Munich
2016-2025
Leibniz-Institute for Food Systems Biology at the Technical University of Munich
2016-2025
Medical University of Lodz
2024-2025
Agriculture and Food
2017-2025
The University of Queensland
2017-2025
Institute for Medical Biology
2025
ARC Centre of Excellence for Plant Success in Nature and Agriculture
2017-2023
Helmholtz Zentrum München
2020-2023
National Imaging Facility
2022
Griffith University
2022
As the term "masked mycotoxins" encompasses only conjugated mycotoxins generated by plants and no other possible forms of their modifications, we hereby propose for all these a systematic definition consisting four hierarchic levels. The highest level differentiates free unmodified from those being matrix-associated modified in chemical structure. following lower levels further differentiate, particular, "modified into "biologically modified" "chemically with variations metabolites former...
Recent findings suggest an association between obesity, loss of gut barrier function and changes in microbiota profiles. Our primary objective was to examine the effect caloric restriction subsequent weight reduction on permeability obese women. The impact inflammatory markers fecal also investigated. 4-week very-low calorie diet (VLCD, 800 kcal/day) induced a mean 6.9 ± 1.9 kg accompanied by HOMA-IR (Homeostasis model assessment-insulin resistance), fasting plasma glucose insulin, leptin,...
Drinking or gargling Salvia officinalis L. infusion (sage infusion) is thought to soothe a sore throat, tonsillitis, and inflamed, red gums, although structure-based scientific evidence for the key anti-inflammatory compounds in sage scarce. Human gingival fibroblasts (HGF-1) were treated with (SI) SI fractions containing either its volatile components water (aqueous distillate, AD) dry matter (DM) six hours. SI, AD, DM reduced mean phorbol-12-myristate-13-acetate/ionomycin...
Reactions between sugars and amino acids in the Maillard reaction produce a multitude of compounds through interconnected chemical pathways. The course pathways changes depending on nature as well processing conditions (e.g. temperature, water activity). Some partial have been elucidated using labelled precursors but process is very time intensive. Here, we use rapid, non-targeted analysis with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) to deliver molecular...
There is a critical need to better understand the patterns, levels and combinatory effects of exposures we are facing through our diet environment. Mycotoxin mixtures particular concern due chronic low dose caused by naturally contaminated food. To facilitate new insights into their role in disease, mycotoxins metabolites quantified bio-fluids as biomarkers exposure. Here, describe highly sensitive urinary assay based on ultra-high performance liquid chromatography - tandem mass spectrometer...
Background Obesity has been associated with a more severe disease course in inflammatory bowel (IBD) and epidemiological data identified dietary fats but not obesity as risk factors for the development of IBD. Crohn's is one two major IBD phenotypes mostly affects terminal ileum. Despite recent observations that high fat diets (HFD) impair intestinal barrier functions drive pathobiont selection relevant chronic inflammation colon, mechanisms pathogenesis are known. The aim this study was to...
Ultraperformance liquid chromatography tandem mass spectrometry and Quick, Easy, Cheap, Effective, Rugged, Safe based analytical methodologies to quantitate both free (alternariol (1), alternariol monomethyl ether (2), tenuazonic acid (3), tentoxin (4), altenuene (5), altertoxin-I (6)) conjugated (sulfates glucosides of 1 2) Alternaria toxins in fruit vegetable juices tomato products were developed validated. Acceptable limits quantitation (0.7-5.7 μg/kg), repeatability (RSDr < 15.7%),...
Abstract Folates play a key role in human one‐carbon metabolism and are provided by food. It is well established that folates beneficial the prevention of neural tube defects cardiovascular neurodegenerative diseases. Fruits vegetables, especially green main sources folates. In parallel, fruits with high contents folates, mostly consumed after processing, such as, canning, freezing, or home‐cooking, which involve folate losses during their preparation. Hence, it important to know percentage...
In this study, we monitored the thermal formation of early ribose-glycine Maillard reaction products over time by ion cyclotron resonance mass spectrometry. Here, considered sugar decomposition (caramelization) apart from compounds that could only be produced in presence amino acid. More than 300 intermediates as a result two initial reactants were found after ten hours (100 °C) to participate interplay cascade. Despite large numerical variety majority follow simple and repetitive patterns....
Wheat kernels of the cultivar 'Tommi' were germinated for up to 168 h at 15, 20, 25, or 30 °C. Samples taken different stages germination and analyzed quantitative protein composition using an extraction/HPLC method, folate vitamers a stable isotope dilution assay, soluble, insoluble, total dietary fiber gravimetric method. Gluten proteins substantially degraded during germination. During first degradation glutenins was predominant, whereas longer times required degrade gliadins. The optimal...
This study evaluates the potential mechanism of action and bioactivity black tea pomace for type 2 diabetes prevention via inhibition carbohydrate hydrolyzing enzymes. Black leaves were extracted in hot water was 70% acetone. The phenolic content extract (WBT) acetone extracts (AOBT) 5.77 8.9 mg/mL, respectively, both based on same concentration solid extract. subjected to C18 extraction resulting hydrophobic fraction (HBBT) further LH-20 recover a low molecular weight enriched (LMW) high...
Alternaria fungi are widely distributed saprophytes and plant pathogens. As pathogens, infect crops vegetables cause losses in the fields during postharvest storage. While farmers suffer from declining yields, consumers endangered by formation of secondary metabolites, because some these exhibit a pronounced toxicological potential. The evaluation capabilities is still ongoing will contribute to valid risk assessment. Additionally, data on incidence quantity mycotoxins found food products...
A reliable and practical multi-method was developed for the quantification of mycotoxins in plasma, urine, feces pigs, plasma excreta broiler chickens using liquid chromatography–tandem mass spectrometry. The targeted belong to regulated groups, i.e., aflatoxins, ochratoxin Fusarium mycotoxins, two groups emerging Alternaria enniatins. In addition, method transferred a LC-high resolution spectrometry instrument qualitatively determine phase I II metabolites, which analytical standards are...
A comprehensive definition introducing the term "modified mycotoxins" to encompass all possible forms in which mycotoxins and their modifications can occur was recently proposed has rapidly gained wide acceptance within scientific community. It is becoming increasingly evident that exposure such modified due presence food feed potential pose a substantial additional risk human animal health. Zearalenone (ZEN) well-characterized Fusarium toxin. Considering diversity of ZEN occurring feed,...
Pyrrolizidine alkaloids (PA) and their N-oxides (PANO) are a group of toxic secondary plant metabolites occurring predominantly as contaminants in (herbal) teas, honeys food supplements, well spices culinary herbs. Depending on the botanical origin contaminating plant, pattern PA/PANO can strongly vary within sample. The current study aimed to broaden existing data occurrence For this, 305 authentic samples covering 15 different matrices mainly harvested 2016 or 2017 originating from 36...