A5019566760- Trace Elements in Health
- Drug Transport and Resistance Mechanisms
- Heavy Metal Exposure and Toxicity
- Aluminum toxicity and tolerance in plants and animals
- Antiplatelet Therapy and Cardiovascular Diseases
- Phytochemical Studies and Bioactivities
- Magnolia and Illicium research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Spinal Hematomas and Complications
- Sirtuins and Resveratrol in Medicine
- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Iron Metabolism and Disorders
- Advanced Glycation End Products research
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Ethnobotanical and Medicinal Plants Studies
- Consumer Attitudes and Food Labeling
- Traditional and Medicinal Uses of Annonaceae
- Metal complexes synthesis and properties
- Biochemical effects in animals
- Folate and B Vitamins Research
- Porphyrin Metabolism and Disorders
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
University of Naples Federico II
2020
University of Vienna
2011-2016
University of Wisconsin–Madison
2012
Oregon Health & Science University
2002-2009
Drinking or gargling Salvia officinalis L. infusion (sage infusion) is thought to soothe a sore throat, tonsillitis, and inflamed, red gums, although structure-based scientific evidence for the key anti-inflammatory compounds in sage scarce. Human gingival fibroblasts (HGF-1) were treated with (SI) SI fractions containing either its volatile components water (aqueous distillate, AD) dry matter (DM) six hours. SI, AD, DM reduced mean phorbol-12-myristate-13-acetate/ionomycin...
Copper is essential for the growth and development of mammalian cells. The key role in intracellular distribution copper belongs to recently discovered family metallochaperones copper-transporting P-type ATPases. mutations ATPase ATP7B, Wilson's disease protein (WNDP), lead accumulation severe hepatic neurological abnormalities. Several these were shown disrupt protein-protein interactions between WNDP metallochaperone Atox1, suggesting that are important normal homeostasis. To understand...
Significance Intracellular zinc is tightly controlled because essential but potentially toxic. Many organisms regulate using storage vesicles/organelles, whether mammals do so unknown. Here, we show that human ZIP13 releases from vesicular stores. Previous studies found mutations in the gene, SLC39A13 , cause spondylocheiro dysplastic form of Ehlers–Danlos syndrome (SCD-EDS) and speculated exports early secretory pathway overload endoplasmic reticulum causes SCD-EDS. In contrast, our study...
The Wilson's disease protein (WNDP) is a copper-transporting ATPase regulating distribution of copper in the liver. Mutations WNDP lead to severe metabolic disorder, disease. function depends on Atox1, cytosolic metallochaperone that delivers WNDP. We demonstrate metal-binding site 2 (MBS2) N-terminal domain (N-WNDP) plays an important role this process. transfer one from Atox1 N-WNDP results selective protection metal-coordinating cysteines MBS2 against labeling with cysteine-directed...
Pitanga, Eugenia uniflora L., is a tropical fruit, which may be consumed as juice. While beneficial health effects of L. leaf extracts have extensively been studied, limited data are available on an anti-inflammatory potential pitanga The aim the presented study was to investigate properties juice with regards prevention inflammation-related periodontal diseases. For this purpose, six healthy volunteers swirled juice, containing 35% pulp, for 10 min. Thereafter, oral gum epithelial cells...
Melanoidins are Maillard reaction products similar to dietary fiber but their effect on food intake was under-investigated. A randomized, crossover study of 14 healthy subjects investigated whether melanoidins modulated energy and affected the postprandial dynamics 21 gut-brain modulators appetite including gastrointestinal peptides, endocannabinoids, N-acylethanolamines neuropeptides. At breakfast consumed a bread enriched with either 3 g coffee (CM), (BM), or conventional (CT). Energy...
Copper-transporting ATPase ATP7B is essential for human copper homeostasis and normal liver function. has six N-terminal metal-binding domains (MBDs) that sense cytosolic levels regulate ATP7B. The mechanism of sensing signal integration from multiple MBDs poorly understood. We show communicate this communication determines the oxidation state conformation entire domain (N-ATP7B). Mutations copper-coordinating Cys to Ala in any MBD (2, 3, 4, or 6) change N-ATP7B have distinct functional...
This study was designed to compare the anti-inflammatory potential of a Magnolia officinalis L. bark extract solely or in combination with extracts prepared from either Polygonum aviculare L., Sambucus nigra Isodon japonicus bacterial lipopolysaccharide (LPS) stimulated human gingival fibroblasts (HGF-1) and U-937 monocytes, as cell models periodontal disease. HGF-1 cells were incubated LPS Porphyromonas gingivalis Escherichia coli together four plant alone combination. Secretion cytokines...
A bstract : Wilson's disease protein (WNDP) is a copper‐transporting P 1 ‐type ATPase which plays key role in normal distribution of copper number tissues, particularly the liver and brain. Copper has numerous effects on WNDP, altering its structure, activity, intracellular localization. To better understand function this regulation by copper, we have recently developed functional expression systems for WNDP Atox1, cytosolic that serves as an donor WNDP. Here summarize results our...
Abstract Scope: trans ‐Resveratrol has been shown to improve insulin sensitivity and enhance cellular glucose uptake. Evidence from recent studies indicates that these effects depend on SIRT1‐pathways. Methods results: Since ingestion of resveratrol leads the presence metabolites in body, we aimed at investigating (i) whether a daily dose 300 mg resveratrol/kg body weight healthy male Wistar rats for period 8 wk affects selected parameters lipid metabolism (ii) resulting plasma...
Inflammatory diseases of the periodontal tissues are known health problems worldwide. Therefore, anti-inflammatory active compounds used in oral care products to reduce long-term inflammation. In addition inducing inflammation, pathogen attack leads an increased production reactive oxygen species (ROS), which may lead oxidative damage macromolecules. Magnolia officinalis L. bark extract (MBE) has been shown possess antioxidant and potential vitro. present study, influence MBE-fortified...