A5000654664- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Atrial Fibrillation Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Myasthenia Gravis and Thymoma
- Cerebrovascular and Carotid Artery Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Neuropathies and Disorders
- Antifungal resistance and susceptibility
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Cerebrospinal fluid and hydrocephalus
- Stroke Rehabilitation and Recovery
- Spinal Hematomas and Complications
- Pharmacological Effects and Toxicity Studies
- Adipose Tissue and Metabolism
- Cerebral Venous Sinus Thrombosis
- Autoimmune Neurological Disorders and Treatments
- Cystic Fibrosis Research Advances
- Neurological Disease Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
Universitätsklinikum Gießen und Marburg
2018-2025
Universitätsklinikum Erlangen
2016-2025
Giessen School of Theology
2023-2024
Justus-Liebig-Universität Gießen
2022-2024
Brain (Germany)
2023-2024
Philipps University of Marburg
2024
West China Hospital of Sichuan University
2024
Sichuan University
2024
Center for Behavioral Brain Sciences
2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2014-2023
<h3>Importance</h3> Although use of oral anticoagulants (OACs) is increasing, there a substantial lack data on how to treat OAC-associated intracerebral hemorrhage (ICH). <h3>Objective</h3> To assess the association anticoagulation reversal and blood pressure (BP) with hematoma enlargement effects OAC resumption. <h3>Design, Setting, Participants</h3> Retrospective cohort study at 19 German tertiary care centers (2006-2012) including 1176 individuals for analysis long-term functional...
Objective To investigate parameters associated with hematoma enlargement in non–vitamin K antagonist oral anticoagulant (NOAC)‐related intracerebral hemorrhage (ICH). Methods This retrospective cohort study includes individual patient data for 190 patients NOAC‐associated ICH over a 5‐year period (2011–2015) at 19 departments of neurology across Germany. Primary outcome was the association prothrombin complex concentrate (PCC) administration enlargement. Subanalyses were calculated blood...
To determine demographic characteristics, clinical features, treatment regimens, and outcome of myasthenic crisis (MC) requiring mechanical ventilation (MV).Analysis patients who presented with MC between 2006 2015 in a German multicenter retrospective study.We identified 250 cases 12 participating centers. Median age at was 72 years. duration MV days. Prolonged (>15 days) depended on (p = 0.0001), late-onset myasthenia gravis (MG), high Myasthenia Gravis Foundation America Class before...
<b><i>Background and Purpose:</i></b> Stroke-associated immunosuppression inflammation are increasingly recognized as factors that trigger infections thus, potentially influence the outcome after stroke. Several studies demonstrated elevated neutrophil-to-lymphocyte ratio (NLR) is a significant predictor of adverse outcomes in patients with ischemic However, little known about impact NLR on short-term mortality intracerebral hemorrhage (ICH)....
Stroke-associated immunosuppression and inflammation are increasingly recognized as factors triggering infections thus potentially influencing outcome after stroke. Several studies have demonstrated that elevated neutrophil-to-lymphocyte ratio (NLR) is a significant predictor of adverse outcomes for patients with ischemic stroke or intracerebral hemorrhage. Thus far, in subarachnoid hemorrhage the association between NLR insufficiently established. The authors sought to investigate on...
<h3>Objective:</h3> As common prognostication models in intracerebral hemorrhage (ICH) are developed variably including patients with early (<24 hours) care limitations (ECL), we investigated its interaction maximally treated and sought to provide a new unbiased severity assessment tool. <h3>Methods:</h3> This observational cohort study analyzed consecutive ICH (n = 583) from prospective registry over 5 years. We characterized the influence of ECL on overall outcome by propensity score...
Evidence is lacking regarding acute anticoagulation management in patients after intracerebral haemorrhage (ICH) with implanted mechanical heart valves (MHVs). Our objective was to investigate reversal and resumption strategies by evaluating incidences of haemorrhagic thromboembolic complications, thereby defining an optimal time-window when restart therapeutic (TA) MHV ICH.We pooled individual patient-data (n = 2504) from a nationwide multicentre cohort-study (RETRACE, conducted at 22...
To evaluate the association of perihemorrhagic edema (PHE) evolution and peak extent with day 90 functional outcome in patients intracerebral hemorrhage (ICH) identify pathophysiologic factors influencing evolution.This retrospective cohort study included spontaneous supratentorial ICH between January 2006 2014. PHE volumes were studied using a validated semiautomatic volumetric algorithm. Multivariable logistic regression propensity score matching (PSM) accounting for age, volume, location...
Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein predominantly in microglia within the central nervous system (CNS). TREM2 regulates multiple microglial functions, including lipid metabolism, immune reaction, inflammation, and phagocytosis. Recent studies have found that highly activated after ischemic stroke. However, role of pathologic response stroke remains unclear. Herein, TREM2-deficient exhibit an impaired phagocytosis rate cholesteryl ester (CE)...
Background: Stroke stimulates reactive astrogliosis, aquaporin 4 (AQP4) depolarization and neuroinflammation.Preconditioned extracellular vesicles (EVs) from microglia exposed to hypoxia, in turn, reduce poststroke brain injury.Nevertheless, the underlying mechanisms of such effects are elusive, especially with regards inflammation, AQP4 polarization, cerebrospinal fluid (CSF) flow.Methods: Primary astrocytes were oxygen-glucose deprivation (OGD) injury.For analyzing role expression patterns...
<h3>Objective</h3> To assess intensive care unit (ICU) complications, their management, and prognostic factors associated with outcomes in a cohort of patients autoimmune encephalitis (AE). <h3>Methods</h3> This study was an observational multicenter registry consecutively included diagnosed AE requiring Neuro-ICU treatment between 2004 2016 from 18 tertiary hospitals. Logistic regression models explored the influence diagnostic findings on dichotomized (0–3 vs 4–6) modified Rankin Scale...
Intraventricular hemorrhage (IVH) is a negative prognostic factor in intracerebral (ICH) and associated with permanent shunt dependency substantial proportion of patients post-ICH. IVH treatment by intraventricular fibrinolysis (IVF) was recently linked to reduced mortality rates the CLEAR III study IVF represents safe effective strategy hasten clot resolution that may reduce rates. Additionally, promising results from observational studies reported reductions for combined approach plus...
Background and Purpose: It is unestablished whether andexanet alfa, compared with guideline-based usual care including prothrombin complex concentrates, associated reduced hematoma expansion (HE) mortality in patients factor-Xa inhibitor–related intracerebral hemorrhage (ICH). We the occurrence of HE clinical outcomes treated either alfa or during acute phase ICH. Methods: Data were extracted from multicenter, prospective, single-arm ANNEXA-4 trial (Andexanet Alfa, a Novel Antidote to...
Abstract Stem cell‐based therapies and extracellular vesicle (EV) treatment have demonstrated significant potential for neuroprotection against ischemic stroke. Although the neuroprotective mechanisms are not yet fully understood, targeting microglia is central to promoting neuroprotection. Microglia resident immune cells of nervous system. These crucial in pathogenesis They respond rapidly site injury by releasing pro‐inflammatory cytokines, phagocytizing dead debris, recruiting peripheral...
Abstract Background Lipid droplets (LD), lipid-storing organelles containing neutral lipids like glycerolipids and cholesterol, are increasingly accepted as hallmarks of inflammation. The nuclear paraspeckle assembly transcript 1 (NEAT1), a long non-coding RNA with over 200 nucleotides, exerts an indispensable impact on regulating both LD agglomeration autophagy in multiple neurological disorders. However, knowledge to how NEAT1 modulates the formation associated signaling pathways is...
Myasthenic crises (MC) are potentially life‐threatening acute exacerbations of myasthenia gravis (MG) characterized by profound muscle weakness, bulbar symptoms, and potential for respiratory failure. Intravenous immunoglobulins (IVIG) plasma exchange (PLEX) conventional treatments myasthenic exacerbations. Recently, new therapeutic options generalized acetylcholine‐receptor antibody positive (AchR+) MG were approved as an add‐on therapy. They mainly consist complement C5 inhibitors such...
Abstract Microglia are critically involved in post‐stroke inflammation affecting neurological outcomes. Lipid droplet (LD) accumulation microglia results a dysfunctional and pro‐inflammatory state the aged brain worsens outcome of neuroinflammatory neurodegenerative diseases. However, role LD‐rich (LDRM) under stroke conditions is unknown. Using vitro vivo models, herein patterns microglial LD their corresponding inflammatory signaling cascades studied. Interactions between temporal spatial...
Abstract Introduction To date only two studies have evaluated anemia status in acute intracerebral hemorrhage (ICH) reporting that on admission (OAA) was associated with larger hematoma volume, and lower hemoglobin levels during hospital stay, which related to poorer outcome. The question remains whether influences outcome through volume-effects or itself has an independent impact? Methods This single-center investigation included 435 consecutive patients spontaneous ICH admitted the...
<h3>Background and Objectives</h3> To assess seizure characteristics in antibody (ab)-associated autoimmune encephalitis (ab + AE) with the 3 most prevalent abs against N-methyl-d-aspartate receptor (NMDAR), leucine-rich glioma-inactivated protein 1 (LGI1), glutamic acid decarboxylase (GAD). <h3>Methods</h3> Multicenter nationwide prospective cohort study of German Network for Research Autoimmune Encephalitis. <h3>Results</h3> Three hundred twenty patients ab AE were eligible analysis: 190...
Background: Telestroke has proven efficacy in improving clinical outcomes by providing rapid access to specialized stroke care, particularly remote areas. However, the global implementation of telestroke networks remains uneven, with limited data on their structure and coverage outside high-income countries (HICs). Objective: This study aimed provide a comprehensive overview landscape networks, highlighting disparities underscoring need for universal guidelines. We map landscape,...