A5054714801- Evolution and Genetic Dynamics
- Fatty Acid Research and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Sphingolipid Metabolism and Signaling
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
Universitätsmedizin Göttingen
2024
University of Göttingen
2024
Abstract Microglia are critically involved in post‐stroke inflammation affecting neurological outcomes. Lipid droplet (LD) accumulation microglia results a dysfunctional and pro‐inflammatory state the aged brain worsens outcome of neuroinflammatory neurodegenerative diseases. However, role LD‐rich (LDRM) under stroke conditions is unknown. Using vitro vivo models, herein patterns microglial LD their corresponding inflammatory signaling cascades studied. Interactions between temporal spatial...
This investigation explores the potential of plasma lipidomic signatures for aiding in diagnosis Multiple Sclerosis (MS) and evaluating clinical course disease activity diseased patients. Plasma samples from 60 patients with MS (PwMS) were clinically stratified to either a relapsing-remitting (RRMS) or chronic progressive age-matched controls analyzed using state-of-the-art direct infusion quantitative shotgun lipidomics. To account confounders, data filtered age BMI correlations. The...