A5084828703- Orthopaedic implants and arthroplasty
- Cystic Fibrosis Research Advances
- Colorectal Cancer Treatments and Studies
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Colorectal Cancer Surgical Treatments
- Neonatal Respiratory Health Research
- Hip disorders and treatments
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Inhalation and Respiratory Drug Delivery
- Radiomics and Machine Learning in Medical Imaging
- Wnt/β-catenin signaling in development and cancer
- Effects and risks of endocrine disrupting chemicals
- Bone Tissue Engineering Materials
- HER2/EGFR in Cancer Research
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Hip and Femur Fractures
- Bioinformatics and Genomic Networks
- Colorectal and Anal Carcinomas
- Advanced X-ray and CT Imaging
- Medical and Biological Sciences
- Thyroid Cancer Diagnosis and Treatment
- Computational Drug Discovery Methods
University Medical Center
2025
Universitätsmedizin Göttingen
2015-2024
University of Göttingen
2015-2024
Hadassah Medical Center
2021
Hospital for Sick Children
2021
Centre Français des Fonds et Fondations
2021
Goethe University Frankfurt
2007
Giessen School of Theology
1993
Universitätsklinikum Gießen und Marburg
1993
Justus-Liebig-Universität Gießen
1987
In patients with advanced rectal cancer (cUICC II and III) multimodality therapy resulted in better long-term local tumor control. Ongoing clinical trials are focusing on intensification to improve disease-free (DFS) cancer-specific survival (CSS), the integration of biomarkers for prediction individual recurrence risk, identification new targets. this context, we investigated HER-2, a member epidermal growth factor receptor family, whose expression pattern role was unclear cancer. A total...
Abstract Microglia are critically involved in post‐stroke inflammation affecting neurological outcomes. Lipid droplet (LD) accumulation microglia results a dysfunctional and pro‐inflammatory state the aged brain worsens outcome of neuroinflammatory neurodegenerative diseases. However, role LD‐rich (LDRM) under stroke conditions is unknown. Using vitro vivo models, herein patterns microglial LD their corresponding inflammatory signaling cascades studied. Interactions between temporal spatial...
Intrinsic and acquired resistance to the monoclonal antibody drug trastuzumab is a major problem in treatment of HER2-positive breast cancer. A deeper understanding underlying mechanisms could help develop new agents. Our intention was detect genes single nucleotide polymorphisms (SNPs) affecting efficiency cell culture. Three cancer lines with different phenotypes were analyzed. We chose BT474 as model sensitivity, HCC1954 intrinsic resistance, BTR50, derived from BT474, resistance. Based...
Abstract The aim of this study was to discriminate malignant and benign clinical T1 renal masses on routinely acquired computed tomography (CT) images using radiomics machine learning techniques. Adult patients undergoing surgical resection histopathological analysis were included. Preoperative CT studies in venous phase from multiple referring centers included, without restriction specific scanners, slice thickness, or degrees artifacts. Renal segmented 120 standardized radiomic features...
Don't look sharp, fuzzy. A technique for "fuzzy" pharmacophore screening is presented. Two prospective applications with RNA targets were performed: virtual inhibitors of the Tat-TAR interaction and in vitro protein expression. The hits contain alternative scaffolds found through a fuzzy model (see figure) ligand binding poses. Supporting information this article available on WWW under http://www.wiley-vch.de/contents/jc_2268/2007/z700195_s.pdf or from author. Please note: publisher not...
Multidisciplinary tumor boards (MDT) have been advocated as standard of care in modern oncology. German guidelines for metastasized colorectal cancer (mCRC) recommend MDT discussion colon patients after completion primary therapy but stage IV well rectal prior to any therapy. In this health research study, we evaluated application and decisional consequences approach clinical routine.
// Hanna Styczen 1 , Iris Nagelmeier 2 Tim Beissbarth 3 Manuel Nietert Kia Homayounfar Thilo Sprenger Ute Boczek Kathrin Stanek Julia Kitz 4 Hendrik A. Wolff 5 B. Michael Ghadimi Peter Middel Torsten Liersch Josef Rüschoff Lena-Christin Conradi Department of General, Visceral and Pediatric Surgery, University Medical Center, Göttingen, Germany Targos Molecular Pathology, Pathology Nordhessen, Kassel, Statistics, Radiotherapy Radiooncology, Correspondence to: Conradi, e-mail:...
The cystic fibrosis (CF) sweat gland is defective in β-adrenergically-stimulated secretion the coil and chloride reabsorption duct. Whereas regularly assessed by quantitative pilocarpine iontophoresis (QPIT), measurement of β-adrenergic not yet established clinical practice.A novel bubble imaging protocol was developed that determines rates automatic recording, processing quality control kinetics droplet formation.Treatment CF patients with CFTR modulators elexacaftor, tezacaftor ivacaftor...
Introduction Oncogenic mutation within the KRAS gene represents a negative predictor for treatment response to anti-epidermal growth factor receptor (EGFR) in patients with colorectal cancer. Recently, we have shown no relevant heterogeneity status and between pre- posttherapeutic samples from primary tumor locally advanced rectal The aim of this study was evaluate intertumoral corresponding metastasis or local recurrence similar cohort ideal representative tissue testing. Materials methods...
Abstract Objectives To develop an automatic segmentation model for solid renal tumors on contrast-enhanced CTs and to visualize with associated confidence promote clinical applicability. Materials methods The training dataset included tumor patients from two tertiary centers undergoing surgical resection receiving CT in the corticomedullary or nephrogenic contrast media (CM) phase. Manual was performed all axial slices serving as reference standard segmentations. Independent testing publicly...
Introduction: Evidence for the efficiency of highly-effective triple-CFTR-modulatory therapy with elexacaftor/tezacaftor/ivacaftor (ETI), either demonstrated in clinical trials or by vitro testing, is lacking about 10% people cystic fibrosis (pwCF) rare mutations. Comprehensive assessment CFTR function can provide critical information on impact ETI gains such mutations, lending argument prescription ETI. The mutation c.165-2A>G a acceptor splice that has not yet been functionally...
This investigation explores the potential of plasma lipidomic signatures for aiding in diagnosis Multiple Sclerosis (MS) and evaluating clinical course disease activity diseased patients. Plasma samples from 60 patients with MS (PwMS) were clinically stratified to either a relapsing-remitting (RRMS) or chronic progressive age-matched controls analyzed using state-of-the-art direct infusion quantitative shotgun lipidomics. To account confounders, data filtered age BMI correlations. The...
Abstract Translational research relies on high-quality biospecimens. In patients with rectal cancer treated preoperatively radiochemotherapy tissue based analyses are challenging. To assess quality challenges we analyzed samples taken over the last years in a multicenter setting. We retrospectively evaluated overall 197 of CAO/ARO/AIO-94- and 04-trial locally advanced that were biopsied at University Medical Center Goettingen as well 10 cooperating hospitals Germany. The cellular content...
As a result of deficiency at birth, disease or trauma, there are people who have no limbs from the hip joint downwards. These possibillity locomotion without use other devices such as wheelchairs disarticulation prostheses. these prostheses used by all ages, different in their grade physical activities and weights, subject to stresses related circumstances. The European Level 2 Draft Standard prEN 12523: 1966 “External limb external orthoses — requirements test methods” contains strength for...
Different causative therapeutics for CF patients have been developed. There are still no mutation-specific some patients, especially those with rare CFTR mutations. For this purpose, high-throughput screens performed which result in various candidate compounds, mostly unclear modes of action. In order to elucidate the mechanism action promising substances and be able predict possible synergistic effects substance combinations, we used a systems biology approach create model maturation...
Abstract Background Brain metastasis represents a major complication with significantly shorter overall survival of many oncological diseases, in particular lung cancer, breast cancer and malignant melanoma patients. However, despite the poor prognosis, sometimes clinical decision-making, between on one hand not to harm patient other withholding potential therapeutic option, is very challenging. Thus aim this retrospective study was compare various scores, including scores for activities...