A5088680060- Dialysis and Renal Disease Management
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Vitamin C and Antioxidants Research
- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
- Tracheal and airway disorders
- Advanced Glycation End Products research
- Vitamin D Research Studies
- Renal function and acid-base balance
- Erythropoietin and Anemia Treatment
- Blood Pressure and Hypertension Studies
- Inhalation and Respiratory Drug Delivery
- Blood groups and transfusion
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Metabolism and Genetic Disorders
- Acute Kidney Injury Research
- Iron Metabolism and Disorders
- Asthma and respiratory diseases
- Lipoproteins and Cardiovascular Health
- Hemoglobinopathies and Related Disorders
- Antioxidant Activity and Oxidative Stress
- Heme Oxygenase-1 and Carbon Monoxide
- Renal and related cancers
- Adrenal Hormones and Disorders
Université Paris Cité
2010-2025
Inserm
2013-2025
Hôpital Necker-Enfants Malades
2013-2025
Institut Necker Enfants Malades
2011-2025
Assistance Publique – Hôpitaux de Paris
2012-2024
Centre National de la Recherche Scientifique
1996-2024
Laboratoire de Biochimie
1999-2022
Délégation Paris 5
2008-2013
Institut National de Recherche en Santé Publique
2008
University Hospital of Lausanne
2007
We previously demonstrated the presence of advanced oxidation protein products (AOPP), a novel marker oxidative stress in plasma uremic patients receiving maintenance dialysis. The present study cohort 162 showed that concentrations AOPP increased with progression chronic renal failure and were closely related to glycation end (AGE)-pentosidine (r = 0.52, p < 0.001), taken as AGE. In vivo, relevance AGE-pentosidine monocyte-mediated inflammatory syndrome associated uremia was evidenced by...
Accelerated atherosclerosis resulting in an abnormally high incidence of coronary and cerebrovascular occlusive accidents has been repeatedly reported dialysis patients, but risk factors such complications chronic renal failure (CRF) predialysis patients are debated.We prospectively assessed the first myocardial cerebral infarction episodes a cohort 147 CRF (99 male) followed from January 1985 to December 1994. Relevant clinical laboratory for atherogenesis were determined at yearly...
Background. Oxidative stress has long been demonstrated in haemodialysis patients. However, the factors influencing their oxidative status have not characterized extensively these Therefore, present study was designed to investigate influence of a large number known be associated with stress.
Chronic renal failure (CRF) favors the development of atherosclerosis and excessive calcification atheromatous lesions. CRF was induced in apolipoprotein E knockout (apoE(-/-)) mice to study (1) a possible acceleration aortic atherosclerosis, (2) degree type vascular calcification, (3) factors involved process. For creating CRF, 8-wk-old gene underwent partial kidney ablation. Control animals sham operation. Aortic atherosclerotic plaques were evaluated using quantitative morphologic image...
Late nephrological referral of chronic renal failure patients has been shown to be associated with high morbidity and short-term mortality on dialysis. However, the impact predialysis care duration (PNCD) long-term survival dialysis had not evaluated.We studied data from all 1057 consecutive who started treatment at Necker Hospital 1989 1998 (mean age start 53.8+/-17.2 years (range 18-91 years), excluding analysis presented acute (n=60) or advanced malignancy (n=35). We evaluated effects...
The novel phosphate binder sevelamer has been shown to prevent the progression of aortic and coronary calcification in uremic patients. Whether it also decreases atheromatous plaques is unknown. aim our study was examine effect administration on development atherosclerosis apolipoprotein E-deficient mouse as an established model accelerated atherosclerosis.Female mice were randomly assigned 4 groups: 2 groups nonuremic (sevelamer versus control) control). Sevelamer given at 3% with chow....
Background. Atherosclerosis and vascular calcifications are common causes of morbidity mortality in maintenance haemodialysis patients. In addition to the well-known traditional risk factors, uraemia-specific factors appear enhance dramatically progression pathological processes involved. The aim present study was evaluate degree atherosclerosis chronic patients using non-invasive imaging methods, identify potentially involved factors. Methods. included 73 (36 females, 37 males), aged 25–75...
Background. There is increasing evidence for the presence of oxidative stress and vitamin C deficiency in dialysis patients. Limited data, however, are available regarding effects supplementation on inflammation markers such
Two highly potent and selective cystic fibrosis (CF) transmembrane regulator (CFTR) inhibitors have been identified by high-throughput screening: the thiazolidinone CFTR(inh)-172 [3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]- 2-thioxo-4-thiazolidinone] glycine hydrazide GlyH-101 [N-(2-naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide]. Inhibition of CFTR chloride channel these compounds has suggested to be pharmacological interest in treatment...
To estimate the capacity of plasma from septic shock patients to induce in vitro reactive oxygen species (ROS) production by endothelial cells and analyze whether ROS is related severity shock.Prospective, observational study.Medical intensive care unit a university hospital.Twenty-one with shock.The naive human umbilical vein (HUVEC) was quantified using fluorescent probe (2',7'-dichlorodihydrofluorescein diacetate).Blood samples were collected on day 1, 3, 5 21 consecutive adult ten...
Background.Atherosclerosis and vascular calcification (VC) progression in chronic kidney disease is favored by disturbances of mineral metabolism. We compared the effect phosphate binder lanthanum (La) carbonate with sevelamer-HCl on atherosclerosis, VC bone structure function mice renal failure (CRF).
Cystinuria is a purely renal, rare genetic disease caused by mutations in cystine transporter genes and characterized defective reabsorption leading to kidney stones. In 14% of cases, patients undergo nephrectomy, but given the difficulty predict evolution disease, identification markers damage would improve follow-up with higher risk. The aim present study develop robust, reproducible, noninvasive methodology for proteomic analysis urinary exosomes using high resolution mass spectrometry. A...