A5060672622- Atrial Fibrillation Management and Outcomes
- Blood properties and coagulation
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Parathyroid Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Cardiovascular Health and Disease Prevention
- Dialysis and Renal Disease Management
- Cardiovascular and Diving-Related Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Obstructive Sleep Apnea Research
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Advanced Glycation End Products research
- Cardiac tumors and thrombi
- Blood Coagulation and Thrombosis Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Aortic Thrombus and Embolism
- Cardiovascular Disease and Adiposity
John Paul II Hospital
2015-2024
Institute of Cardiology
2002-2024
Jagiellonian University
2002-2024
University of Occupational and Environmental Health Japan
2002
Background. Atherosclerosis and vascular calcifications are common causes of morbidity mortality in maintenance haemodialysis patients. In addition to the well-known traditional risk factors, uraemia-specific factors appear enhance dramatically progression pathological processes involved. The aim present study was evaluate degree atherosclerosis chronic patients using non-invasive imaging methods, identify potentially involved factors. Methods. included 73 (36 females, 37 males), aged 25–75...
It has been shown that type 2 diabetes (DM) is associated with enhanced thrombin generation and formation of denser fibrin clots reduced lysability. We sought to investigate the impact duration versus glycaemia control on clot phenotype its determinants in diabetic patients. In 156 consecutive Caucasian patients we investigated ex vivo generation, fibrinolytic proteins, along plasma permeation (Ks), compaction, turbidity, efficiency tissue plasminogen activator (t-PA)-mediated fibrinolysis....
Type 2 diabetes mellitus (T2DM) is associated with a hypercoagulable state and increased neutrophil extracellular traps formation (NETosis). We investigated predictors of NETosis cell death markers in circulating blood their association prothrombotic T2DM. In cross-sectional study involving 113 T2DM patients aged 63.7 ± 8.2 years, we citrullinated histone H3 (H3Cit), cell-free deoxyribonucleic acid (cfDNA), myeloperoxidase, elastase, inflammation markers, along thrombin generation (TG),...
Abstract Introduction Mortality in systemic lupus erythematosus (SLE) patients is influenced by an increased occurrence of severe cardiovascular complications. Statins have been proven to protect a wide spectrum SLE from these This study was conducted determine the possible efficacy atorvastatin as assessed multi-detector computed tomography (MDCT)-based coronary calcium scoring and single photon emission (SPECT) myocardium. Methods Sixty stable clinical conditions were randomized receive...
Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular diseases. The aim of the study was to assess influence OSAS on endothelial dysfunction and thrombosis biomarkers evaluate effect treatment with continuous positive airway pressure (CPAP) biomarker levels.
Abstract Background Type 2 diabetes mellitus (T2DM) patients are at high risk of cardiovascular (CV) events. Factor XI (FXI) is associated with arterial thromboembolism, including myocardial infarction (MI), stroke, and CV mortality. The role FXI in T2DM unknown. We investigated whether plasma events long-term observation. Methods In 133 (aged 66 ± 8 years, 40.6% women, median duration 5 [2–10] years) we assessed levels, along fibrin clot properties, thrombin generation, fibrinolysis...
Aortic valve fenestrations are defined as a loss of aortic leaflet tissue. They common but overlooked finding with unclear significance. The aim this study was to investigate the varied functional anatomies fenestrations. A total 400 formalin-fixed autopsied human hearts were macroscopically assessed and function 16 reanimated imaged using Visible Heart® methodologies. present in 43.0% (in one 24.0%, two leaflets 16.0%, all 3.0%). Fenestrations mostly left (25.5%) followed by right (23.3%)...
IntroductIon Peripheral artery disease (PAD) has a prevalence between 3% and 10% in the general population is associated with 6-fold increase cardiovascular mortality. 1PAD strongly advanced age.Patients early onset of represent only 1% PAD but have particularly progressive involvement carotid coronary arteries. 2Higher risk failed bypass surgery leading to amputations reported patients premature compared their older counterparts. 3 Despite fact that traditional atherosclerosis factors...
Background: Non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly used for stroke prevention in patients with atrial fibrillation (AF) worldwide. Few articles have compared current understanding of AF about the disease and anticoagulant therapy relation to medications used. Aim: We sought compare knowledge anticoagulation between treated NOACs those on vitamin antagonists (VKAs). Methods: Jessa Knowledge Questionnaire (JAKQ), developed validated Belgium. Patients were...
Aims . We sought to investigate whether enhanced oxidation contributes unfavorable fibrin clot properties in patients with diabetes. Methods assessed plasma permeation (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mi>K</mml:mi></mml:mrow><mml:mrow><mml:mi>s</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>, a measure of the pore size networks) and lysis time induced by recombinant tissue plasminogen activator (CLT) 163 consecutive...
To investigate the effect of low blood glucose on thrombin generation and fibrin clot properties in type 2 diabetes (T2DM).In 165 patients with T2DM high cardiovascular risk, we measured ex vivo plasma permeation [Ks], turbidity efficiency fibrinolysis including lysis time [t50%], together platelet activation markers relation to fasting glucose.As compared medium (4.5-6.0 mmol/l, n = 52) higher (>6.0 75) group, subjects glycemia (<4.5 38) had lower Ks by 11% (p < 0.001) 8% 0.01),...
Abstract The left atrial appendage (LAA) is well known as a source of cardiac thrombus formation. Despite its clinical importance, the LAA neck still anatomically poorly defined. Therefore, this study aimed to define and determine morphometric characteristics. We performed three‐dimensional reconstructions heart chambers based on contrast‐enhanced electrocardiography–gated computed tomography scans 200 patients (47% females, 66.5 ± 13.6 years old). was defined truncated cone‐shaped canal...
An increasing body of evidence suggests that atherosclerosis in patients with uremia differs from found general population terms advancement and localization vascular lesions. It has also been suggested different non-invasive techniques system evaluation are designed to show types lesions (i.e. calcification, stiffness or “classical” atherosclerosis). The aim the study was search for possible associations between results obtained three methods assessment sites treated peritoneal dialysis...
We investigated clinical and laboratory determinants of plasma protein oxidation its associations with clot fibrinolysis in type 2 diabetes patients. Our cross-sectional study consisted 246 diabetic patients, 143 (58%) concomitant cardiovascular disease (CVD), including 41 (17%) previous myocardial infarction (MI). measured total carbonylation (PC), thiobarbituric acid reactive substances (TBARS) antioxidant capacity (TAC) along lysis time (CLT) permeation (Ks ), fibrinogen, plasminogen,...
BACKGROUND The Jessa Atrial Fibrillation Knowledge Questionnaire (JAKQ) was successfully used to assess knowledge gaps in patients with atrial fibrillation (AF). AIMS To evaluate the regional differences among Polish their awareness of AF diagnosis and oral anticoagulation use. METHODS A total 1583 at a median (IQR) age 72 (66-79) years completed JAKQ 3 cardiology centers (center I, Kraków; center II, Toruń; III, Kielce) from January 2017 June 2018. final analysis included 1525 patients,...
Background and Purpose- We investigated whether clot permeability can predict clinically relevant outcomes in patients with atrial fibrillation (AF) treated rivaroxaban. Methods- In the cohort study, we enrolled 232 consecutive AF on rivaroxaban 20 mg/d (76.3%) or 15 (23.7%) for at least 3 months. Plasma (Ks), a measure of fibrin network density, was determined 24 to 30 hours since intake undetectable drug's levels. Ischemic cerebrovascular events bleedings were recorded. Results- During...
Summary Type 2 diabetes is associated with faster formation of poorly lysable, denser fibrin clots and elevated cellular fibronectin (cFn), a marker vascular injury. We investigated whether cFn affects clot properties in type diabetes. In 200 consecutive patients 100 control subjects matched for age sex, we determined plasma along degradation using turbidimetric permeability assays. Diabetic had (median, 3.99 [interquartile range, 2.87–4.81] µg/ml]), increased density (MaxAbsC) prolonged...