A5025213596- RNA regulation and disease
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Inflammation biomarkers and pathways
- Neurological Disease Mechanisms and Treatments
Universitätsmedizin Göttingen
2023
Mianyang Central Hospital
2022
University of Göttingen
2022
Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein predominantly in microglia within the central nervous system (CNS). TREM2 regulates multiple microglial functions, including lipid metabolism, immune reaction, inflammation, and phagocytosis. Recent studies have found that highly activated after ischemic stroke. However, role of pathologic response stroke remains unclear. Herein, TREM2-deficient exhibit an impaired phagocytosis rate cholesteryl ester (CE)...