A5010949123- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Cardiac and Coronary Surgery Techniques
- Cardiac Health and Mental Health
- Functional Brain Connectivity Studies
- Anesthesia and Neurotoxicity Research
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Pain Mechanisms and Treatments
- Anesthesia and Sedative Agents
- Botulinum Toxin and Related Neurological Disorders
- Dementia and Cognitive Impairment Research
- Aortic Disease and Treatment Approaches
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Neuroscience and Neural Engineering
- Dysphagia Assessment and Management
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- User Authentication and Security Systems
- Biometric Identification and Security
- Neurogenetic and Muscular Disorders Research
- Hereditary Neurological Disorders
- Cardiac pacing and defibrillation studies
- Multimodal Machine Learning Applications
Kerckhoff Klinik
2019-2025
Schott (Germany)
2023-2024
Karlsruhe University of Applied Sciences
2022-2024
Universitätsklinikum Gießen und Marburg
2019-2023
Justus-Liebig-Universität Gießen
2020-2023
Brain (Germany)
2023
Giessen School of Theology
2021
Goethe University Frankfurt
2013-2016
Friedrich-Alexander-Universität Erlangen-Nürnberg
2000
Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein predominantly in microglia within the central nervous system (CNS). TREM2 regulates multiple microglial functions, including lipid metabolism, immune reaction, inflammation, and phagocytosis. Recent studies have found that highly activated after ischemic stroke. However, role of pathologic response stroke remains unclear. Herein, TREM2-deficient exhibit an impaired phagocytosis rate cholesteryl ester (CE)...
Following cardiac surgery, postoperative cognitive decline (POCD) is a common complication that can impair the quality of life and increase mortality. The aim this study was to investigate whether early training decrease POCD after surgery.The multi-centred, two-arm, randomized (1:1 ratio), controlled trial involving older patients undergoing elective heart valve surgery with extracorporeal circulation. Recruitment took place at Department Cardiac Surgery Kerckhoff-Clinic in Bad Nauheim...
Hypoxia triggers reactive microglial inflammation and lipid droplet (LD) accumulation under stroke conditions, although the mutual interactions between these two processes are insufficiently understood. Hence, involvement of transforming growth factor (TGF)-β1 in LD cultured microglia exposed to hypoxia were analyzed herein. Primary oxygen-glucose deprivation (OGD) injury lipopolysaccharide (LPS) stimulation. For analyzing role TGF-β1 patterns such a siRNA an exogenous recombinant protein...
Abstract The apolipoprotein E ε4 (ApoE ε4) allele not only represents the strongest single genetic risk factor for sporadic Alzheimer's disease, but also imposes independent effects on brain function in healthy individuals where it has been shown to promote subtle memory deficits and altered intrinsic functional network connectivity. Based previous work showing a potential relevance of default mode (DMN) connectivity episodic function, we hypothesized that ApoE genotype would affect...
Abstract Background Heart surgery is a risk factor for objectively and subjectively assessable postoperative cognitive decline (POCD), which relevant everyday life. The aim of this study was to investigate whether early training has an impact on health‐related quality life failures in daily living after cardiac surgery. Methods two‐arm, randomized, controlled, outcome‐blinded trial involving older patients undergoing elective heart valve with extracorporeal circulation (ECC). Recruitment...
Abstract The Functional Oral Intake Scale (FOIS) is the most frequently used scale for evaluation of functional oral intake by dysphagia patients. FOIS was validated using data from Videofluoroscopic Swallowing Study (VFSS). Until now, a German version Flexible Endoscopic Evaluation (FEES) lacking. aim this study cross-cultural validation (FOIS-G) FEES. translation original carried out according to Translation, Review, Adjudication, Pretesting, Documentation (TRAPD) methodology. For process,...
The apolipoprotein E (ApoE) ɛ4 allele is a well-established genetic risk factor for sporadic Alzheimer's disease. Some evidence suggests negative role of the ApoE cognitive performance in late life, while beneficial effects on cognition have been shown young age. We investigated age-related gene brain function by assessing performance, as well functional activation patterns during retrieval Face-Name pairs group (n = 50; age 26.4±4.6 years, 25 carriers) and old 40; 66.1±7.0 20 participants....
The occurrence of postoperative cognitive deficits, especially after heart surgery, has been demonstrated in several studies. These deficits can clearly be noticed by the patients and their close relatives daily life. Furthermore, decrease quality life social functioning earning capacity. aim this study is to investigate whether early training reduce subjective objective deficits.The proposed a multicenter, two-arm, randomized controlled trial involving 144 elderly undergoing elective...
Introduction Postoperative delirium (POD) and postoperative cognitive decline (POCD) can be observed after cardiosurgical interventions. Taken together, these neurocognitive disorders (PNCDs) contribute to increased morbidity mortality. Preoperative risk factors of PNCD, such as decreased neuropsychometric performance or daily activities, interpreted reduced reserve. This study aims build up reserves protect against the development PNCD through preoperative, home-based, training. Methods The...
Patients undergoing cardiac surgery often develop delirium which increases the risk of postoperative morbidity and leads to a reduced quality life. Retrospective studies show higher incidence in patients with seizures. However, these do not systematically detect subclinical seizures, so seizures after remains speculative. The objective this study is determine prevalence electrographic elective open-chamber surgery. This prospective, blinded, monocentric, observational investigated scheduled...
In this study, differences of unmyelinated nerve fiber density in sural biopsy material from patients suffering neuropathies unknown origin with (n=14) or without pain (n=13) were analyzed. Immunocytochemistry was applied to differentiate afferent sensory and efferent sympathetic fibers. All evaluated for deficits small function thermotesting, quantitative sudomotor-axon reflex-testing testing painfulness mechanical stimuli before performing the biopsy. No difference found between concerning...
Background and purpose Dysphagia is common in acute stroke leads to worse overall outcome. Transesophageal echocardiography (TEE) used the diagnostic evaluation of with regard its etiology a known cause postoperative dysphagia cardiac surgery. The prevalence patients undergoing TEE remains unknown. aim Echocardiography – Risk Acute Stroke (TEDRAS) study was assess influence on swallowing among who have experienced stroke. Methods TEDRAS prospective, blind, randomized, controlled trial that...
The rapid development of face anti-spoofing techniques has resulted in a wide variety techniques, making it difficult to make meaningful comparisons and choices among them. This research aims shed light on this aspect by delving into various passive methods that rely solely the observation person front camera. Our study encompasses execution, examination, comparative evaluation these methodologies. Furthermore, we analyze attacks examine how different demonstrate their effectiveness...
Postoperative cognitive decline (POCD) or decreased health-related quality of life (HQL) have been reported after cardiac surgery. A previous investigation showed beneficial effects postoperative training on POCD and HQL 3 months heart Here, we present the 12-month follow-up results.This bicentric, 1:1 randomised treatment-as-usual controlled trial included elderly patients scheduled for elective valve The consisted paper-and-pencil-based exercises practising multiple functions 36 min/day 6...
During cardiosurgical procedures that use extracorporeal circulation (ECC), a variety of neurological complications can occur, and postoperative cognitive deficits remain an unsolved problem. Among the sources these are intraoperatively detectable cerebral microemboli, which mainly consist air. This study's purpose was to assess neuroprotective effects reducing gaseous microemboli using dynamic bubble trap (DBT) in patients undergoing pulmonary endarterectomy (PEA) for treatment chronic...
Background and Objectives: After major heart surgery, some patients report visual hallucinations that cannot be attributed to psychosis or delirium. This study aimed investigate the hallucination incidence in after coronary artery bypass grafting with (on-pump) without (off-pump) extracorporeal circulation. Materials Methods: A total of 184 consecutive listed for elective on- off-pump were prospectively enrolled into study. Preoperative baseline investigations 24-48 h before surgery (t0)...
BackgroundPostoperative cognitive deficits (POCD) after cardiosurgical interventions, are well described through objective psychometric tests. However, patients' subjective perception is essential to clinical assessment and quality of life. This study systematically evaluated patient reported POCD between subjects undergoing coronary artery bypass grafting heart valve replacement.MethodsThis was a multicenter, prospective questionnaire survey conducted at the cardiac surgery departments...
Older age and the presence of Apolipoprotein E (ApoE) ε 4 allele are both risk factors for sporadic Alzheimer's disease (AD). Findings from previous work have led to hypothesis that ApoE4 genotype may confer a bimodal effect, benefitting cognitive performance at young age, while being detrimental an older age. However, clear evidence this assumption is missing. The aim present study was test possible interactions between ApoE on memory memory-related brain activation by assessing healthy...
Veränderungen neuronaler Oszillationen in Basalganglien und Kortex spielen eine wichtige Rolle der Pathophysiologie Parkinson-Krankheit (PK). Parkinson-Patienten zeigen insbesondere verstärkte oszillatorische Aktivität im Nucleus subthalmicus (STN) weiteren Basalganglienkernen. Neurophysiologische Studien konnten zeigen, dass STN kohärent zu kortikalen Arealen sind. Eine Lokalisation dieser Areale wurde jedoch bisher nicht vorgenommen.