A5042120203- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Pluripotent Stem Cells Research
- Neuroscience and Neural Engineering
- CRISPR and Genetic Engineering
- Barrier Structure and Function Studies
- Nuclear Receptors and Signaling
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- SARS-CoV-2 and COVID-19 Research
- Neurogenesis and neuroplasticity mechanisms
- Hand Gesture Recognition Systems
- Tactile and Sensory Interactions
- Drug Transport and Resistance Mechanisms
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- SARS-CoV-2 detection and testing
- Intensive Care Unit Cognitive Disorders
- Pediatric health and respiratory diseases
- Autophagy in Disease and Therapy
- Genetic Neurodegenerative Diseases
- Prion Diseases and Protein Misfolding
- Cholesterol and Lipid Metabolism
- Infection Control and Ventilation
Martin Luther University Halle-Wittenberg
2019-2025
University Hospital in Halle
2019-2022
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2020
Luther University
2019
Universitätsmedizin Göttingen
2014
The present research moves in the direction of enabling a bidirectional communication between subject brain and prosthetic limb, by providing prosthesis with an artificial cutaneous sensing through electronic skin. In this preliminary study, skin response to applied mechanical stimuli is conveyed human using electrotactile stimulation. Experimental tests on two healthy subjects show that short training reinforced learning increased considerably success rate identification impact location....
Late-onset Alzheimer disease (LOAD) is the most frequent neurodegenerative disease, and APOE ε4 allele prominent risk factor for LOAD. Four human induced pluripotent stem cell (iPSC) lines MLUi007-J, MLUi008-B, MLUi009-A, MLUi010-B were generated from LOAD patients healthy matched donors by reprogramming of B-lymphoblastoid cells (B-LCLs) with episomal plasmids. The application B-LCLs holds a great promise to model other diseases because they can easily be primary peripheral blood...
Abstract Late-onset Alzheimer’s disease (AD) is a complex multifactorial disease. The greatest known risk factor for late-onset AD the E4 allele of apolipoprotein E (APOE), while increasing age non-genetic factor. cell type-specific functions neural stem cells (NSCs), in particular their plasticity, remain poorly explored context pathology. Here, we describe new model that employs patient-derived induced pluripotent (iPSCs) to generate NSCs and examine role played by APOE4 expression aging...
The pathophysiology of many neuropsychiatric disorders is still poorly understood. Identification biomarkers for these diseases could benefit patients due to better classification and stratification. Exosomes excreted into the circulatory system can cross blood–brain barrier carry a cell type-specific set molecules. Thus, exosomes are source potential diseases, including disorders. Here, we investigated exosomal proteins produced from human-induced pluripotent stem cells (iPSCs) iPSC-derived...
Abstract Purpose We investigated the protection offered by vaccinations and previous infections for household transmission of Omicron variant SARS-CoV-2. Methods 34,666 participants German DigiHero cohort study with two or more members were invited to a prospective between June December 2022. In case positive SARS-CoV-2 test in household, symptom diaries completed at least 14 days. Dry blood spots (DBS) taken from all beginning six eight weeks later. DBS analyzed antibodies. Results 1191...
The function of the blood-brain barrier (BBB) is impaired in late-onset Alzheimer disease (LOAD), but associated molecular mechanisms, particularly with respect to high-risk APOE4/4 genotype, are not well understood. For this purpose, we developed a multicellular isogenic model neurovascular unit (NVU) based on human induced pluripotent stem cells.The NVU was modeled vitro using co-cultures astrocytes, brain capillary endothelial-like cells (BCECs), microglia-like cells, neural (NSCs), and...
The function of the human blood–brain barrier (BBB), consisting mainly basement membrane and microvascular endothelial cells, is to protect brain regulate its metabolism. Dysfunction BBB can lead increased permeability, which be linked with several pathologies, including meningitis, sepsis, postoperative delirium. Advanced glycation end products (AGE) are non-enzymatic, posttranslational modifications proteins, affect their function. Increased AGE levels strongly associated ageing...
After several months of an almost total ban on mass gathering events (MGE) due to the coronavirus disease 2019 (COVID-19), cultural, creative and event industry (CCEI) is trying return commercially viable occupancy rates while keeping SARS-CoV-2 transmission at a low level. To support this, we assessed suitability feasibility hygiene concept during series regular handball matches in May June 2021 with increasing spectator numbers by on-site observation. In addition, questionnaires were...
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Using digital human models (DHMs) as the virtual representation of body enables integration ergonomic assessments in product design process. Especially use DHMs early phases can be decisive for competitive factors such ergonomics or usability. Therefore, we present a method automatic posture generation grasping tasks using musculoskeletal model. This analyses without knowledge designer subject tests. We implemented presented cylinder scenario open source software OpenSim. Subsequently,...
Veränderungen neuronaler Oszillationen in Basalganglien und Kortex spielen eine wichtige Rolle der Pathophysiologie Parkinson-Krankheit (PK). Parkinson-Patienten zeigen insbesondere verstärkte oszillatorische Aktivität im Nucleus subthalmicus (STN) weiteren Basalganglienkernen. Neurophysiologische Studien konnten zeigen, dass STN kohärent zu kortikalen Arealen sind. Eine Lokalisation dieser Areale wurde jedoch bisher nicht vorgenommen.
Alzheimer's disease (AD) is the most common cause of dementia in elderly. Accumulation intercellular β-amyloid plaques and intracellular neurofibrillary tangles are two hallmarks AD that may drive neuronal death corresponding dramatic loss cognitive abilities. A complex interaction between genetic environmental factors contributes to molecular processes AD. Microglial-mediated key determinants accumulation ß-amyloid deposits AD, playing roles amyloid degradation, initiation growth plaques....
The risk for Alzheimer's disease (AD), the most common type of dementia, increases with age resulting in a major challenge ageing society. Dysfunction blood-brain barrier (BBB) contributes to AD progression and characteristic accumulation amyloid-β (Aβ) peptides. Recently, genome-wide association studies (GWAS) participation our research team revealed significant between ATP-binding cassette transporter A7 (ABCA7) late-onset form (LOAD). It was shown that ABCA7 is involved Aβ homeostasis,...
Introduction Neurodegenerativ disease or psychiatirc disorders like Alzheimerʼs (AD) and schizophrenia (SCZ) are associated with a loss of neurons. Neurodegeneration is regulated by aging defect occuring during neural development. A functional neurons affects the plasticity – ability brain to adapt on stimuli our environment. Additionally, from epidemological studies last years, we know many common genetic risk factors for both disease, leading question, if can also find in iPS-cell derived...
Introduction Accumulation of amyloid-β (Aβ) peptides is one pathological hallmark late-onset Alzheimerʼs disease (LOAD), the most common type dementia. Dysregulation and later on breakdown blood-brain barrier (BBB) contributes worsens course disease. The ε4 allele apolipoprotein E (APOE) was identified by GWAS as associated genetic risk factor for developing LOAD. APOE participates in several metabolic pathways including lipid transport, Aβ aggregation, clearance. However, molecular cellular...