A5015474641- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Adaptive Control of Nonlinear Systems
- Retinoids in leukemia and cellular processes
- Immune Cell Function and Interaction
- Diet and metabolism studies
- Tissue Engineering and Regenerative Medicine
- Rabbits: Nutrition, Reproduction, Health
- Neuroscience and Neural Engineering
- Apelin-related biomedical research
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Reproductive Physiology in Livestock
- 3D Printing in Biomedical Research
- Growth Hormone and Insulin-like Growth Factors
- Pluripotent Stem Cells Research
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Pregnancy-related medical research
Martin Luther University Halle-Wittenberg
2016-2023
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2019
Stromal mesenchymal stem cells (MSCs) have the capability to self-renew and can differentiate into multiple cell types of mesoderm germ layer, but their properties are affected by molecular aging mechanisms. MSCs be obtained from adipose tissue termed as adipose-derived stem/stromal (ASCs) representing a promising tool for studying age-related diseases in detail. ASCs young (16 weeks) old (>108 rabbits were successfully isolated propagated. showed typical morphology stained positive CD105,...
Abstract Obesity is a widely spread disease and crucial risk factor for malign disorders, including breast cancer of women in the postmenopause. Studies demonstrated that case obesity natural killer (NK) cell functions like combating tumor cells are affected. This study aims to analyze NK receptor expression obese mice model postmenopausal cancer. Therefore, female BALB/c were fed either high fat or standard diet. Thereafter, ovaries ectomized syngeneic orthotopical injection 4T1-luc2 mouse...
Abstract Late-onset Alzheimer’s disease (AD) is a complex multifactorial disease. The greatest known risk factor for late-onset AD the E4 allele of apolipoprotein E (APOE), while increasing age non-genetic factor. cell type-specific functions neural stem cells (NSCs), in particular their plasticity, remain poorly explored context pathology. Here, we describe new model that employs patient-derived induced pluripotent (iPSCs) to generate NSCs and examine role played by APOE4 expression aging...
Preimplantation embryos are sensitive to maternal hormones affecting embryonic signal transduction and metabolic functions. We examined whether adiponectin, the most abundantly secreted adipokine, can influence glucose transport in mouse cells. In blastocysts full-length adiponectin stimulated uptake, while no effect of globular was found. Full-length translocation GLUT8 transporter cell membrane; we did not detect significant changes intracellular localization GLUT4 adiponectin-treated...
Advanced maternal age is associated with adverse pregnancy outcomes and the decline of female fertility in mammals. A potential reason for reduced metabolic changes due to protein modifications by advanced glycation end products. To elucidate aging process reproduction, we analysed a key enzyme detoxification reactive dicarbonyls, glyoxalase 1 (GLO1), reproductive organs blastocysts young old rabbits at preimplantation stage. At day 6 post coitum, uterine, oviductal, ovarian tissue from...
Stem cell ageing results in loss of organ function and onset age-related diseases, like Alzheimer's disease (AD). AD is the most common form dementia. The characterized by complex molecular genetics, cognitive impairment, progressive neurodegeneration, brain atrophy. Different therapeutic approaches are being developed to counteract affected neurons. Another approach aims modulation stem plasticity existing neuronal progenitors for increasing their dividing capacity regeneration tissue....