A5037302321- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Cerebral Venous Sinus Thrombosis
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Intensive Care Unit Cognitive Disorders
- Cardiac and Coronary Surgery Techniques
- Ultrasound and Hyperthermia Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiovascular and Diving-Related Complications
- Intracranial Aneurysms: Treatment and Complications
- Photoacoustic and Ultrasonic Imaging
- Autoimmune Neurological Disorders and Treatments
- Cardiac Health and Mental Health
- Dysphagia Assessment and Management
- Venous Thromboembolism Diagnosis and Management
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Advanced Neuroimaging Techniques and Applications
- Takotsubo Cardiomyopathy and Associated Phenomena
- S100 Proteins and Annexins
- Angiogenesis and VEGF in Cancer
- Aortic Disease and Treatment Approaches
- Anesthesia and Sedative Agents
Kerckhoff Klinik
2009-2024
Justus-Liebig-Universität Gießen
2013-2024
Brain (Germany)
2013-2024
Universitätsklinikum Gießen und Marburg
2014-2023
Friedensau Adventist University
2014-2021
Giessen School of Theology
2004-2021
Ostalb-Klinikum Aalen
2021
Universitätsklinikum Würzburg
2021
University of Würzburg
2021
University of Lübeck
1995-2009
Background and Purpose— Brain edema is a life-threatening consequence of stroke leads to an extension the affected tissue. The space-occupying effect due brain can be quantified in rat models with use MRI. present study was performed test 2 hypotheses: (1) Can quantification serve as noninvasive measure for water content? (2) Does morphometric assessment swelling allow determination true infarct size on MRI after correction edema? Methods— Thirty rats were subjected permanent suture middle...
Background and Purpose— Transcranial color-coded duplex sonography has become a standard diagnostic technique to assess the intracranial arterial status in acute stroke. It is increasingly used for evaluation of prognosis success revascularization multicenter trials. The aim this international consensus procedure was develop recommendations on methodology documentation be assessment occlusion monitoring recanalization. Methods— Thirty-five experts participated process. presented were...
Background and Purpose Transcranial color-coded duplex sonography (TCCS) enables visualization of the intracranial parenchymal structures measurement blood flow velocity in basal cerebral arteries. The present study aims to evaluate prospectively clinical usefulness TCCS patients with acute stroke. Methods Eighty-four consecutive central nervous symptoms suggesting stroke were investigated within first 48 hours after onset. was performed a 2.5-MHz sector transducer through temporal bone...
<b>Objectives:</b> To evaluate in a prospective multicentre setting the feasibility of transcranial colour coded duplex sonography (TCCS) for examination middle cerebral artery (MCA) patients with acute hemispheric stroke, and to assess validity sonographic findings subgroup who also had correlative angiographic examination. <b>Methods:</b> TCCS was performed 58 consecutive within six hours onset moderate severe stroke. Ultrasound contrast agent (Levovist) applied if necessary. Thirty two...
Transcranial duplex color‐flow sonography provides visualization of intracranial structures, and measures angle‐corrected blood flow velocity in the basal cerebral artenes adults. In 44 patients with central nervous system disease, oblique diameters third middle part lateral ventricle were measured by transcranial using a 2.5‐MHz transducer, compared to computed tomography measurements. The correlation coefficients for ventncle measurements r = 0.83 (p < 0.0001, N 38) 0.73 78),...
Recanalization in dural sinus thrombosis (DST) has been observed previously; however, systematic prospective data are lacking. The influence of recanalization on DST outcome not yet thoroughly evaluated.Thirty-seven consecutive patients with were prospectively examined. Neurological deficits graded the National Institutes Health Stroke Scale (NIHSS) hospital admission and discharge. Functional was assessed modified Rankin (mRS) discharge after 12 months. All treated intravenous heparin acute...
AimsThe purpose of the study was to investigate whether intra-operative filter devices protect brain during coronary artery bypass grafting (CABG) and determine impact solid gaseous micro-emboli on neuropsychological functioning.
Background and Purpose —Transcranial color-coded duplex sonography (TCCS) allows bedside imaging of intracranial hemodynamics parenchymal structures. It provides reliable information regarding midline shift (MLS) in space-occupying hemispheric stroke. We studied the value MLS measurement to predict fatal outcome at different time points after stroke onset. Methods —Forty-two patients with acute, severe were enrolled. Cranial computed tomography (CCT) extracranial performed on admission. TCCS...
Investigating focal cerebral ischemia requires animal models that are relevant to human stroke. Complications and side effects common among these models. The present study describes potential pitfalls in 3 techniques for middle artery occlusion (MCAO) rats using magnetic resonance imaging (MRI) angiography (MRA).Rats were subjected temporary MCAO 90 minutes the suture technique (group I; n=10) or permanent II; macrosphere III; n=10). Clinical evaluation was performed after hours 24 hours....
Cardiac surgery carries a high risk of neurological complications; therefore, these patients would be an appropriate target population for neuroprotective strategies. In this study, we evaluated postoperative diffusion-weighted imaging (DWI) as potential surrogate marker brain embolism and its relationship to neurobiochemical markers injury.Of total 45 consecutive undergoing aortic valve replacement, 37 completed preoperative MRI. At the time MRI studies, serum S100beta neuron-specific...
Abstract Oropharyngeal sensitivity plays a vital role in the initiation of swallowing reflex and is thought to decline as part aging-process. Taste smell functions appear with age well. The aim our study was generate data oral healthy participants for future studies analyse age-related changes their interdependence by measuring sensitivity, taste, function. experiment involved 30 younger than older 60. Sensitivity threshold surrogate measured at anterior faucial pillar electrical stimulation...
Transcranial color-coded sonography (TS) allows a noninvasive, accurate evaluation of lateral displacement the third ventricle. The authors studied prognostic value TS monitoring midline shift (MLS) in acute hemispheric stroke.Sixteen patients with middle cerebral artery (MCA) occlusion were investigated. On admission, median modified Scandinavian Stroke Scale (mSSS) score was 6.0 (range, 5 to 8). Five died from herniation (group 1), 10 survived 2), and 1 patient (Patient 16) after...
Extracellular RNA has been shown to induce vascular endothelial growth factor (VEGF)-dependent hyperpermeability in vivo as well vitro. Studies were performed investigate the mechanism of these effects. For permeability studies primary cultures porcine brain-derived microvascular cells (BMECs) and for all other analytical human brain cell line HCMEC/D3 or umbilical vein (HUVECs) used. RNA, but not DNA, initiated signaling events by binding VEGF neuropilin-1, followed VEGF-R2 phosphorylation,...
Pregnancy is associated with increased risk of venous thrombotic events, including cerebral thrombosis. We aimed to study the complications and outcome subsequent pregnancies in women previous thrombosis.Follow-up acute thrombosis at childbearing age included a previously described cohort (International Study Cerebral Vein Dural Sinus Thrombosis). Patients were interviewed by local neurologists assess rate pregnancy outcomes, antithrombotic prophylaxis during pregnancies.A total 119...
Following cardiac surgery, postoperative cognitive decline (POCD) is a common complication that can impair the quality of life and increase mortality. The aim this study was to investigate whether early training decrease POCD after surgery.The multi-centred, two-arm, randomized (1:1 ratio), controlled trial involving older patients undergoing elective heart valve surgery with extracorporeal circulation. Recruitment took place at Department Cardiac Surgery Kerckhoff-Clinic in Bad Nauheim...
To evaluate the diagnostic efficiency and accuracy of contrast-enhanced transcranial color-coded sonography (CE-TCCS).TCCS is hampered by insufficient ultrasonic penetration in 20% cerebrovascular patients.In 47 patients whose basal arteries could not be assessed adequately, 59 TCCS examinations were performed before after administration contrast agent (CA) Levovist. The assessability different cerebral CA was evaluated off-line. Angiographic records available from 11 patients.Satisfactory...