A5048196741- Cerebral Venous Sinus Thrombosis
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Blood Coagulation and Thrombosis Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Cerebrospinal fluid and hydrocephalus
- Epilepsy research and treatment
- Atrial Fibrillation Management and Outcomes
- Ocular Diseases and Behçet’s Syndrome
- EEG and Brain-Computer Interfaces
- Stroke Rehabilitation and Recovery
- Neurological Complications and Syndromes
- Astronomy and Astrophysical Research
- Migraine and Headache Studies
- History and Developments in Astronomy
- Advanced Neuroimaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiac tumors and thrombi
- Cardiac Arrhythmias and Treatments
- Retinal and Optic Conditions
Hospital de Santa Maria
2015-2024
University of Lisbon
2015-2024
Centro Hospitalar Lisboa Norte
2016-2024
Royal Victoria Hospital
2024
Casa Sollievo della Sofferenza
2024
University of Ulster
2024
Ospedale Maggiore
2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2024
The Royal Melbourne Hospital
2024
The University of Melbourne
2024
Background and Purpose— The natural history long-term prognosis of cerebral vein dural sinus thrombosis (CVT) have not been examined previously by adequately powered prospective studies. Methods— We performed a multinational (21 countries), multicenter (89 centers), observational study. Patients were followed up at 6 months yearly thereafter. Primary outcome was death or dependence as assessed modified Rankin Scale (mRS) score >2 the end follow-up. Results— From May 1998 to 2001, 624...
Background and purpose Current guidelines on cerebral venous thrombosis ( CVT ) diagnosis management were issued by the European Federation of Neurological Societies in 2010. We aimed to update previous using a clearer evidence‐based methodology. Method followed Grading Recommendations, Assessment, Development Evaluation system, formulating relevant diagnostic treatment questions, performing systematic reviews writing recommendations based quality available scientific evidence. Results...
Previous studies conducted between 1997 and 2003 estimated that the risk of stroke or an acute coronary syndrome was 12 to 20% during first 3 months after a transient ischemic attack (TIA) minor stroke. The TIAregistry.org project designed describe contemporary profile, etiologic factors, outcomes in patients with TIA who receive care health systems now offer urgent evaluation by specialists.We recruited had within previous 7 days. Sites were selected if they dedicated TIA. We 1-year...
Background and Purpose— The causes of death patients with cerebral venous thrombosis (CVT) have not been systematically addressed in previous studies. We aimed to analyze the predictors during acute phase CVT International Study on Cerebral Vein Dural Sinus Thrombosis (ISCVT) identify preventable or treatable causes. Methods— ISCVT is a multinational, prospective, observational study including 624 occurring between May 1998 2001, which 27 (4.3%) died phase, 21 (3.4%) within 30 days from...
Little is known about the gender-specific manifestations of cerebral venous and sinus thrombosis, a disease that much more common in women than men.We used data International Study on Cerebral Vein Dural Thrombosis (ISCVT), multicenter prospective observational study, to analyze differences clinical presentation, etiology, outcome thrombosis.Four hundred sixty-five total 624 patients were (75%). Women significantly younger, had less often chronic onset symptoms, headache at presentation....
Patients with cerebral venous thrombosis (CVT) are at risk of recurrent thrombotic events (VTEs). Non-vitamin K oral anticoagulants have not been evaluated in randomized controlled trials CVT.To compare the efficacy and safety dabigatran etexilate those dose-adjusted warfarin preventing VTEs patients who experienced a CVT.RE-SPECT CVT is an exploratory, prospective, (1:1), parallel-group, open-label, multicenter clinical trial blinded end-point adjudication (PROBE design). It was performed...
The current proposal for cerebral venous thrombosis guideline followed the Grading of Recommendations, Assessment, Development, and Evaluation system, formulating relevant diagnostic treatment questions, performing systematic reviews all available evidence writing recommendations deciding on their strength an explicit transparent manner, based quality scientific evidence. addresses both therapeutic topics. We suggest using magnetic resonance or computed tomography angiography confirming...
To date, only uncontrolled studies have evaluated the efficacy and safety of endovascular treatment (EVT) in patients with cerebral venous thrombosis (CVT), leading to lack recommendations on EVT for CVT.To evaluate a severe form CVT.TO-ACT (Thrombolysis or Anticoagulation Cerebral Venous Thrombosis) was multicenter, open-label, blinded end point, randomized clinical trial conducted 8 hospitals 3 countries (the Netherlands, China, Portugal). Patients were recruited from September 2011...
Backgound and Purpose— The risk of seizure early after the diagnosis cerebral vein dural sinus thrombosis (CVT) is not known, use prophylactic antiepileptic (AED) medication in acute phase CVT controversial. Methods— In a multicenter, prospective, observational study, we analyzed factors for seizures experienced before was confirmed (presenting seizures) or within following 2 weeks (early seizures). occurrence compared 4 strata related to whether patients received AEDs not. Criteria were...
Backgound and Purpose— The clinical features prognosis of cerebral vein dural sinus thrombosis (CVT) in elderly patients have not been previously described. Methods— In a multicenter prospective observational study, we compared imaging features, risk factors, outcome adult aged <65 (young middle-aged patients) ≥65 years (elderly patients). Results— A total 624 with CVT were registered followed-up for median 16 months. Fifty-one (8.2%) years. Presentation as an isolated intracranial...
Background and Purpose— Although intracerebral hemorrhages are frequent in patients with cerebral venous thrombosis, lead to worse outcome, predictors of outcome thrombosis have never been evaluated adequately powered studies. Methods— This study was conducted as a part the International Study on Cerebral Vein Dural Sinus Thrombosis. We who had an “early hemorrhage,” ie, already present at time diagnosis by logistic regression analysis, modified Rankin scale 3 6 month dependent variable. The...
Background and Purpose— There is no consensus whether to use unfractionated heparin or low–molecular weight for the treatment of cerebral venous thrombosis. We examined effect on clinical outcome each type heparin. Methods— A nonrandomized comparison a prospective cohort study (the International Study Cerebral Vein Dural Sinus Thrombosis) 624 patients with Patients not treated (n=107) those who sequentially received both types (n=99) were excluded from primary analysis. The latter included...
Rationale Endovascular thrombolysis, with or without mechanical clot removal, may be beneficial for a subgroup of patients cerebral venous sinus thrombosis (CVT) who have poor prognosis despite treatment heparin. Published experience endovascular thrombolysis is promising but only based on case series and not controlled trials. Aim The objective the Thrombolysis Anticoagulation Cerebral Venous Thrombosis (TO-ACT) trial to determine if improves functional outcome severe form CVT. Design...
Decompressive neurosurgery is recommended for patients with cerebral venous thrombosis (CVT) who have large parenchymal lesions and impending brain herniation. This recommendation based on limited evidence. We report long-term outcomes of CVT treated by decompressive in an international cohort.
Background and Purpose Interobserver reliability of the diagnosis transient ischemic attack (TIA) is low, TIA made by nonneurologists often erroneous. We sought to validate general practitioners (GPs) hospital emergency service physicians (emergency MDs). Methods A list 20 neurological symptoms was distributed GPs 22 neurologists who graded compatibility each symptom with diagnosis. At least two validated diagnoses for patients under their care or MDs. Results Compared neurologists,...
Background and Purpose— No randomized controlled trial has evaluated the efficacy of steroids in acute cerebral venous thrombosis (CVT). We aimed to analyze effect on outcome patients International Study Cerebral Veins Dural Sinus Thrombosis (ISCVT). Methods— ISCVT is a prospective observational study that included 624 CVT patients. Death or dependence at 6 months was compared between cases (patients treated with steroids) controls not steroids), using 3 designs: (1) Matched case–control...
<i>Background:</i> Around 15% of patients die or become dependent after cerebral vein and dural sinus thrombosis (CVT). <i>Method:</i> We used the International Study on Cerebral Vein Dural Sinus Thrombosis (ISCVT) sample (624 patients, with a median follow-up time 478 days) to develop Cox proportional hazards regression model predict outcome, dichotomised by modified Rankin Scale score >2. From hazard ratios, risk was derived cut-off point selected. The were...
After cerebral vein and dural sinus thrombosis (CVT), there is an increased risk of further venous thromboembolic events (VTEs). Time to a second or systemic thrombotic event factors for recurrence have not been investigated in large prospective studies.We used the International Study on Cerebral Vein Dural Thrombosis, which included 624 patients with CVT followed up median 13.9 months. Outcome measures all symptomatic VTEs recurrence. Potential predictors recurrence, including demographic...