A5049579050- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Voice and Speech Disorders
- Cerebrovascular and Carotid Artery Diseases
- Cerebral Venous Sinus Thrombosis
- Cardiac Health and Mental Health
- Child Nutrition and Feeding Issues
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Ion Transport and Channel Regulation
- Central Venous Catheters and Hemodialysis
- Hallucinations in medical conditions
- Sarcoidosis and Beryllium Toxicity Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Complications and Syndromes
- Vascular Procedures and Complications
- Intramuscular injections and effects
- Erythropoietin and Anemia Treatment
Giessen School of Theology
2024
Kerckhoff Klinik
2019-2024
Justus-Liebig-Universität Gießen
2015-2024
Brain (Germany)
2023-2024
Universitätsklinikum Gießen und Marburg
2018-2024
University Hospital Leipzig
2023
Diakonie Klinikum Jung-Stilling
2019
Ludwig-Maximilians-Universität München
2019
Abstract Oropharyngeal sensitivity plays a vital role in the initiation of swallowing reflex and is thought to decline as part aging-process. Taste smell functions appear with age well. The aim our study was generate data oral healthy participants for future studies analyse age-related changes their interdependence by measuring sensitivity, taste, function. experiment involved 30 younger than older 60. Sensitivity threshold surrogate measured at anterior faucial pillar electrical stimulation...
Following cardiac surgery, postoperative cognitive decline (POCD) is a common complication that can impair the quality of life and increase mortality. The aim this study was to investigate whether early training decrease POCD after surgery.The multi-centred, two-arm, randomized (1:1 ratio), controlled trial involving older patients undergoing elective heart valve surgery with extracorporeal circulation. Recruitment took place at Department Cardiac Surgery Kerckhoff-Clinic in Bad Nauheim...
Abstract Background Heart surgery is a risk factor for objectively and subjectively assessable postoperative cognitive decline (POCD), which relevant everyday life. The aim of this study was to investigate whether early training has an impact on health‐related quality life failures in daily living after cardiac surgery. Methods two‐arm, randomized, controlled, outcome‐blinded trial involving older patients undergoing elective heart valve with extracorporeal circulation (ECC). Recruitment...
Objectives Fibre-endoscopic evaluation of swallowing (FEES) to detect dysphagia is gaining more and importance as a diagnostic tool. Therefore, we have investigated the impact FEES in neurological patients clinical setting. Design Cross-sectional hospital-based registry. Setting Primary acute care department German university hospital. Participants 241patients with various diseases who underwent procedure. secondary outcome measures Dysphagia related comorbidities. Results 267 were performed...
Abstract The Functional Oral Intake Scale (FOIS) is the most frequently used scale for evaluation of functional oral intake by dysphagia patients. FOIS was validated using data from Videofluoroscopic Swallowing Study (VFSS). Until now, a German version Flexible Endoscopic Evaluation (FEES) lacking. aim this study cross-cultural validation (FOIS-G) FEES. translation original carried out according to Translation, Review, Adjudication, Pretesting, Documentation (TRAPD) methodology. For process,...
Diagnosing dysphagia in acute stroke patients is crucial, as this comorbidity determines morbidity and mortality; we therefore investigated the impact of flexible nasolaryngeal endoscopy (FEES) patients.The FEES investigation performed treated at a large university hospital, allocated standard procedure for all suspected dysphagia. We correlated our findings with baseline data, disability status, pneumonia, duration hospitalisation, necessity mechanical ventilation treatment on intensive...
The occurrence of postoperative cognitive deficits, especially after heart surgery, has been demonstrated in several studies. These deficits can clearly be noticed by the patients and their close relatives daily life. Furthermore, decrease quality life social functioning earning capacity. aim this study is to investigate whether early training reduce subjective objective deficits.The proposed a multicenter, two-arm, randomized controlled trial involving 144 elderly undergoing elective...
Neuromyelitis optica (NMO) is an autoimmune disorder of the central nervous system, which characterized by autoantibodies directed against water channel aquaporin-4 (AQP4). As one main regulators in APQ4 supposed to be involved dynamics brain edema. Cerebral edema seriously affects clinical outcome after ischemic stroke; we therefore aimed investigate whether NMO-antibodies may exert same functional effects as AQP4-inhibitor in-vivo acute stroke.Sixteen male Wistar rats were randomized into...
This study was designed to investigate the indirect neuroprotective properties of recombinant human erythropoietin (rhEPO) pretreatment in a rat model transient middle cerebral artery occlusion (MCAO).One hundred and ten male Wistar rats were randomly assigned four groups receiving either 5,000 IU/kg rhEPO intravenously or saline 15 minutes prior MCAO bilateral craniectomy sham craniectomy. Bilateral aimed at elimination space-consuming effect postischemic edema. Diagnostic workup included...
Background and purpose Dysphagia is common in acute stroke leads to worse overall outcome. Transesophageal echocardiography (TEE) used the diagnostic evaluation of with regard its etiology a known cause postoperative dysphagia cardiac surgery. The prevalence patients undergoing TEE remains unknown. aim Echocardiography – Risk Acute Stroke (TEDRAS) study was assess influence on swallowing among who have experienced stroke. Methods TEDRAS prospective, blind, randomized, controlled trial that...
Abstract Cerebral sinus venous thrombosis (CSVT) is an uncommon disease that usually treated with anticoagulation (heparin, low-molecular heparin, or vitamin K-antagonists). We compared treatment edoxaban, oral factor Xa-antagonist, has not been approved in patients CSVT, enoxaparin, a well-established therapy, rat model of CSVT. Fifty male Wistar rats were randomized into 5 groups (10 animals each) and subjected to aluminum chloride (AlCl3)-induced the superior sagittal (SSS) sham...
Postoperative cognitive decline (POCD) or decreased health-related quality of life (HQL) have been reported after cardiac surgery. A previous investigation showed beneficial effects postoperative training on POCD and HQL 3 months heart Here, we present the 12-month follow-up results.This bicentric, 1:1 randomised treatment-as-usual controlled trial included elderly patients scheduled for elective valve The consisted paper-and-pencil-based exercises practising multiple functions 36 min/day 6...
Dysphagia is common in critically ill neurological patients and associated with a high mortality morbidity. Data on the usefulness of flexible endoscopic examination swallowing (FEES) intensive care unit (ICU) are lacking, raising need for evaluation.FEES was performed suspected dysphagia. We correlated findings baseline data, disability status, pneumonia duration hospitalisation, as well mechanical ventilation or tracheotomy.This analysis consisted 125 Most (81; 64,8%) suffered from acute...
We present two cases of ChAdOx1 nCov-19 (AstraZeneca)-associated thrombotic thrombocytopenia syndrome (TTS) and cerebral venous sinus thrombosis (CVST). At the time emergency room presentation due to persistent headache, blood serum levels revealed reduced platelet counts. Yet, 1 or 4 days after onset symptom, first MR-angiography provided no evidence CVST. Follow-up imaging, performed upon headache refractory nonsteroidal pain medication verified CVST 2–10 initial negative MRI. Both...
Abstract Using ferric chloride (FeCl3) to induce experimental superior sagittal sinus (SSS) thrombosis might interfere with magnetic resonance imaging (MRI)-assisted visualization and evaluation of the thrombus, brain parenchyma, quality occlusion. The aim this study was investigate whether aluminum (AlCl3)-induced SSS has comparable properties those FeCl3 without causing artifacts in MRI. induced 14 male Wistar rats by exposure subsequent topical application a filter paper strip soaked...