A5023472696- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Glioma Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Adrenal Hormones and Disorders
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hormonal Regulation and Hypertension
- Meningioma and schwannoma management
- Myasthenia Gravis and Thymoma
- Alzheimer's disease research and treatments
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Parathyroid Disorders and Treatments
- Stress Responses and Cortisol
- TGF-β signaling in diseases
- Chromatin Remodeling and Cancer
- Thyroid Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Electrolyte and hormonal disorders
- Bone Tumor Diagnosis and Treatments
- Ovarian cancer diagnosis and treatment
- Lung Cancer Research Studies
Universität Hamburg
2016-2025
University Medical Center Hamburg-Eppendorf
2016-2025
University of New Mexico
2024
Marienkrankenhaus Hamburg
2007-2021
Johannes Wesling Klinikum Minden
2021
Martini-Klinik
2015-2018
Eppendorf (Germany)
2014-2016
Marienhospital Stuttgart
2006-2012
University of Würzburg
2003
University of Vienna
2003
Adrenocortical carcinoma is a rare neoplasm characterized by high risk of recurrence after radical resection. Whether the use mitotane beneficial as an adjuvant treatment has been controversial. Our aim was to evaluate efficacy in prolonging recurrence-free survival.We performed retrospective analysis involving 177 patients with adrenocortical cancer who had undergone surgery at 8 centers Italy and 47 Germany between 1985 2005. Adjuvant administered Italian (mitotane group), whereas 55 75...
The classification of neoplasms adenohypophysial cells is misleading because the simplistic distinction between adenoma and carcinoma, based solely on metastatic spread poor reproducibility predictive value definition atypical adenomas detection mitoses or expression Ki-67 p53. In addition, current anterior pituitary does not accurately reflect clinical spectrum behavior. Invasion regrowth proliferative lesions persistence hormone hypersecretion cause significant morbidity mortality. We...
Recurrence of adrenocortical carcinoma (ACC) even after complete (R0) resection occurs frequently. The aim this study was to identify markers with prognostic value for patients in clinical setting. From the German ACC registry, 319 European Network Study Adrenal Tumors stage I–III were identified. As an independent validation cohort, 250 from three countries included. Clinical, histological, and immunohistochemical correlated recurrence-free (RFS) overall survival (OS). Although univariable...
Abstract Objective Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA). Context Unilateral PA is most common surgically treated form hypertension. Morphologic examination combined with CYP11B2 (aldosterone synthase) immunostaining reveals diverse lesions resected adrenals. Patients Methods Surgically removed adrenals (n = 37) from 90 patients operated 2015 to 2018 Munich, Germany, were selected represent broad...
Abstract Pituitary neuroendocrine tumors (PitNETs) are classified according to cell lineage, which requires immunohistochemistry for adenohypophyseal hormones and the transcription factors (TFs) PIT1, SF1, TPIT. According current WHO 2022 classification, PitNETs with co-expression of multiple TFs termed “plurihormonal”. Previously, PIT1/SF1 was prevailingly reported in PitNETs, otherwise correspond somatotroph lineage. However, little is known about such classification has not recognized...
Adrenal tumors are usually diagnosed by clinical symptoms of hormone excess. The increasing use ultrasound and computed tomography results in the detection a substantial number incidentally discovered adrenal tumors. Most these nonfunctional adrenocortical adenomas, but few cases subclinical cortisol production "incidentalomas" have been reported. We investigated prospectively prevalence autonomous 68 patients (44 females 24 males, aged 25-90 yr) with incidentalomas at our institution. As...
Structural changes, like atrial fibrosis, may increase the likelihood of fibrillation (AF) occurring in response to triggering events. The influence isolated amyloidosis (IAA) is largely unknown.Right appendages (1 or 2 entire cross sections) were obtained from 245 patients undergoing open-heart surgery. Atrial amyloid was identified by Congo red staining and classified immunohistochemistry. Amyloid found 40 (16.3%) patients, all deposits immunoreactive for natriuretic peptide (ANP)....
THIS STUDY PRESENTS six patients with hypothalamic hamartomas diagnosed on the basis of magnetic resonance imaging. Histological confirmation was performed in three who underwent surgery. Immunohistological assays were used to determine neurosecretory pattern. Four presented epilepsy, including gelastic seizures. Other symptoms included behavioral abnormalities four and precocious puberty visual impairment two patients. One patient associated developmental defects. Good results without...
No immunohistochemical marker has been established to reliably differentiate adrenocortical tumors from other adrenal masses. A panel of markers like melan-A and inhibin-α is currently used for this purpose but suffers limited diagnostic accuracy. We hypothesized that expression steroidogenic factor-1 (SF-1), a transcription factor involved in development, value the differential diagnosis masses predicts prognosis carcinoma (ACC).SF-1 protein was assessed by immunohistochemistry on tissue...
The aim of this study was to examine pituitary adenomas in a series postmortem pituitaries by use modern technologies immunostaining, classify the according current WHO classification and analyse possible associations available clinical data.In study, 3048 autopsy cases obtained from years 1991-2004 were examined.A total 334 found 316 pituitaries. One hundred thirty-two sparsely granulated prolactin cell (39.5%), 75 null (22.5%) 31 oncocytomas diagnosed. Forty-six ACTH (13.8%, 27 densely...
Pituitary adenomas are common neoplasms of the anterior pituitary gland. Germ-line mutations in aryl hydrocarbon receptor-interacting protein ( AIP ) gene cause adenoma predisposition (PAP), a recent discovery based on genetic studies Northern Finland. In this population, founder mutation explained significant proportion all acromegaly cases. Typically, PAP patients were young age at diagnosis but did not display strong family history adenomas. To evaluate role susceptibility other...
Background Aldosterone producing lesions are a common cause of hypertension, but genetic alterations for tumorigenesis have been unclear. Recently, either two recurrent somatic missense mutations (G151R or L168R) was found in the potassium channel KCNJ5 gene aldosterone adenomas. These alter selectivity filter and result Na+ conductance cell depolarization, stimulating production proliferation. Because similar mutation occurs Mendelian form primary aldosteronism, these appear to be...
The term atypical pituitary adenoma (APA) was revised in the 2004 World Health Organization (WHO) classification of tumors. However, two four parameters required for diagnosis APAs were formulated rather vaguely (i.e., “extensive” nuclear staining p53; “elevated” mitotic index). Based on a case-control study using representative cohort typical adenomas and selected from German Pituitary Tumor Registry, we aimed to obtain reliable cut-off values both p53 index. In addition, analyzed impact...
Medical treatment in Cushing's disease (CD) is limited due to poor understanding of its pathogenesis. Pathogenic variants ubiquitin specific peptidase 8 (USP8) have been confirmed as causative around half corticotroph tumors. We aimed further characterize the molecular landscape those CD tumors lacking USP8 mutations a large cohort patients.Exome sequencing was performed on 18 paired tumor-blood samples with wild-type status. Candidate gene were screened by Sanger 175 additional samples. The...
Clinical and histopathologic differentiation of cystic lesions from the sellar region, that is, craniopharyngiomas (CPs) Rathke cleft cysts (RCCs), is challenging has paramount importance with respect to variable clinical manifestation adapted surgical treatment strategies in both entities. Here, we retrospectively evaluated clinico-pathologic findings 81 patients presenting a tumor located region. All underwent transsphenoidal or transcranial resections. Microscopic inspection specimens...
Abstract Objective: The somatostatin analog octreotide preferentially binds to receptor (sst) 2A and a lesser extent sst5. Although sst2A sst5 mRNAs are consistently expressed in GH-secreting adenomas, controls GH secretion only 65% of acromegalic patients. Hence, we investigated the immunocytochemical expression sst large group somatotroph tumors. Methods: Acromegalic patients, cared for university referral center, were either operated on without pretreatment (group A, n = 14) or pretreated...
A series of 104 biopsy cases with histopathological proof amyloid, submitted to our department pathology over the last 19 years, were re-examined. The survey investigated medical indication for surgery, origin and quality clinical information as documented on request form examination in hospital records. Amyloid deposits classified using antisera directed against five major amyloid fibril proteins, i.e. AA, ATTR, lambda, kappa beta 2M optimal conditions sought reliable early characterization...