Paola Loli
A5004673392- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Myasthenia Gravis and Thymoma
- Ophthalmology and Eye Disorders
- Carcinogens and Genotoxicity Assessment
- Sexual Differentiation and Disorders
- Bone health and osteoporosis research
- Thyroid Cancer Diagnosis and Treatment
- Occupational and environmental lung diseases
- Pancreatic and Hepatic Oncology Research
- Vitamin D Research Studies
- DNA Repair Mechanisms
- Ion Transport and Channel Regulation
- Parathyroid Disorders and Treatments
- Meningioma and schwannoma management
- Long-Term Effects of COVID-19
- Genetic Syndromes and Imprinting
Vita-Salute San Raffaele University
2021-2024
Ospedale San Carlo
2021-2024
IRCCS Ospedale San Raffaele
2021-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2021-2024
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2014-2023
University of Milan
1999-2020
A. O. Ordine Mauriziano di Torino
2017
Ospedale Maggiore
2007-2015
University of Naples Federico II
2015
Endocrinology Research Center
2013
Adrenocortical carcinoma is a rare neoplasm characterized by high risk of recurrence after radical resection. Whether the use mitotane beneficial as an adjuvant treatment has been controversial. Our aim was to evaluate efficacy in prolonging recurrence-free survival.We performed retrospective analysis involving 177 patients with adrenocortical cancer who had undergone surgery at 8 centers Italy and 47 Germany between 1985 2005. Adjuvant administered Italian (mitotane group), whereas 55 75...
Recurrence of adrenocortical carcinoma (ACC) even after complete (R0) resection occurs frequently. The aim this study was to identify markers with prognostic value for patients in clinical setting. From the German ACC registry, 319 European Network Study Adrenal Tumors stage I–III were identified. As an independent validation cohort, 250 from three countries included. Clinical, histological, and immunohistochemical correlated recurrence-free (RFS) overall survival (OS). Although univariable...
The aim of the study was to define frequency hereditary forms and genotype/phenotype correlations in a large cohort Italian patients with pheochromocytomas and/or functional or nonfunctional paragangliomas.We examined 501 consecutive paragangliomas (secreting nonsecreting). Complete medical family histories, as well results clinical, laboratory, imaging studies, were recorded database. Patients divided into different groups according their history, presence lesions outside...
The long-term outcome of non-functioning pituitary adenoma (NFPA) patients is not clearly established, probably due to the low annual incidence and prolonged natural history these rare tumors. aim this study was evaluate clinical data at presentation post-surgery radiotherapy in a cohort with NFPA.A computerized database developed using Access 2000 software (Microsoft Corporation, 1999). Retrospective registration 295 NFPA performed seven Endocrinological Centers North West Italy. Data were...
Stereotactic radiosurgery by gamma-knife (GK) is an attractive therapeutic option after failure of microsurgical removal in patients with pituitary adenoma. In these tumors or remnants them, it aims to obtain the arrest cell proliferation and hormone hypersecretion using a single precise high dose ionizing radiation, sparing surrounding structures. The long-term efficacy toxicity GK acromegaly are only partially known. Thirty acromegalic (14 women 16 men) entered prospective study treatment....
<h3>Context</h3> Pheochromocytomas and paragangliomas are genetically heterogeneous neural crest–derived neoplasms. We recently identified germline mutations of the novel transmembrane-encoding gene<i>FP/TMEM127</i>in familial sporadic pheochromocytomas consistent with a tumor suppressor effect. <h3>Objectives</h3> To examine prevalence spectrum of<i>FP/TMEM127</i>mutations in to test effect vitro. <h3>Design, Setting, Participants</h3> sequenced the<i>FP/TMEM127</i>gene 990 individuals...
In 2007, a retrospective case-control study provided evidence that adjuvant mitotane prolongs recurrence-free survival (RFS) in patients with radically resected adrenocortical carcinoma (ACC). We aimed to confirm the prognostic role of same series after 9 additional years follow-up. One hundred sixty-two ACC who did not recur or die landmark period 3 months were considered. Forty-seven enrolled four Italian centers where was routinely recommended (mitotane group), 45 no strategy undertaken...
Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medullary thyroid carcinoma (MTC) associated 2A and 2B) or not familial MTC (FMTC) with other due to germline RET gene mutations. The prevalence of these rare diseases their corresponding mutations are unknown the small size study population.We collected data on 250 families hereditary followed in 20 different Italian centres.The most frequent amino acid substitution was Val804Met (19.6%) Cys634Arg (13.6%). A...
<h3>Importance</h3> Large studies investigating long-term outcomes of patients with bilateral pheochromocytomas treated either total or cortical-sparing adrenalectomies are needed to inform clinical management. <h3>Objective</h3> To determine the association vs adrenalectomy pheochromocytoma-specific mortality, burden primary adrenal insufficiency after adrenalectomy, and risk pheochromocytoma recurrence. <h3>Design, Setting, Participants</h3> This cohort study used data from a multicenter...
Adrenocortical carcinoma (ACC) has an aggressive but variable clinical course. Prognostic stratification based on the European Network for Study of Adrenal Tumours stage and Ki67 index is limited. We aimed to demonstrate prognostic role a points-based score (S-GRAS) in large cohort patients with ACC.This multicentre, retrospective study ACC who underwent adrenalectomy.The S-GRAS was calculated as sum following points: tumour (1-2 = 0; 3 1; 4 2), grade (Ki67 0-9% 10-19% ≥20% 2 points),...
BackgroundAdjuvant treatment with mitotane is commonly used after resection of adrenocortical carcinoma; however, remains controversial, particularly if risk recurrence not high. We aimed to assess the efficacy and safety adjuvant compared surveillance alone following complete tumour in patients carcinoma considered be at low intermediate recurrence.MethodsADIUVO was a multicentre, open-label, parallel, randomised, phase 3 trial done 23 centres across seven countries. Patients aged 18 years...
The therapeutic value of ketoconazole for long term treatment patients with Cushing's syndrome was studied. Seven disease and one an adrenal adenoma received 600–800 mg/day 3–13 months. Plasma ACTH, cortisol, dehydroepiandrosterone sulfate levels urinary 17-ketosteroid, tetrahydro- 11-deoxycortisol excretion were determined periodically during the period. ACTH cortisol responses to CRH stimulation before treatment. Rapid subsequently persistent clinical improvement occurred in each patient;...
Heterozygous inactivating mutations in the Gsα gene cause Albright's hereditary osteodystrophy. Consistent with observation that only maternally inherited lead to resistance hormone action [pseudohypoparathyroidism type Ia (PHP Ia)], recent studies provided evidence for a predominant maternal origin of transcripts endocrine organs, such as thyroid, gonad, and pituitary. The aim this study was investigate presence pituitary hypothalamic hormones acting via Gsα-coupled receptors patients PHP...
The pathologic diagnosis of adrenocortical carcinoma (ACC) still needs to be improved, because the renowned Weiss Score (WS) system has a poor reproducibility some parameters and is difficult apply in borderline cases ACC variants. "reticulin algorithm" (RA) defines malignancy through an altered reticulin framework associated with 1 3 following parameter: necrosis, high mitotic rate, vascular invasion. This study aimed at validating interobserver stain evaluation unpublished series 245...
Abstract Context Because of the rarity adrenocortical cancer (ACC), only a few population-based studies are available, and they reported limited details in characterization patients their treatment. Objective To describe nationwide cohort presentation with ACC, treatment strategies, potential prognostic factors. Methods Retrospective analysis 512 diagnosed 12 referral centers Italy from January 1990 to June 2018. Results ACC as incidentalomas accounted for overall 38.1% cases, frequency that...