A5055032010- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Parathyroid Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Adrenal and Paraganglionic Tumors
- S100 Proteins and Annexins
- Thyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Growth Hormone and Insulin-like Growth Factors
- BRCA gene mutations in cancer
- Cancer, Hypoxia, and Metabolism
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Bone health and osteoporosis research
- Potassium and Related Disorders
- Regulation of Appetite and Obesity
- Gene expression and cancer classification
- Chromatin Remodeling and Cancer
- Metabolism, Diabetes, and Cancer
- Lung Cancer Research Studies
- Genetics and Neurodevelopmental Disorders
- Skin and Cellular Biology Research
- Glycogen Storage Diseases and Myoclonus
- Bioinformatics and Genomic Networks
Istituti di Ricovero e Cura a Carattere Scientifico
2002-2022
Ospedale Maggiore
2002-2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2001-2022
University of Milan
2003-2021
IRCCS Policlinico San Donato
2015
Research Institute for Endocrine Sciences
2005
IRCCS Istituto Auxologico Italiano
2004
In primary hyperparathyroidism (PHPT), vertebral fractures (VFx) occur regardless of bone mineral density (BMD) and may depend on decreased quality. Trabecular score (TBS) is a texture measurement acquired during spinal dual-energy X-ray absorptiometry (DXA). Recently, TBS has been proposed as an index micro-architecture.We studied 92 PHPT patients (74 females, age 62.1±9.7 years) 98 control subjects. all at baseline, in 20 surgically treated 10 conservatively after 24 months, TBS, (lumbar...
Multiple endocrine neoplasia type 2 (MEN 2) is a genetic disease characterized by medullary thyroid carcinoma (MTC) associated 2A and 2B) or not familial MTC (FMTC) with other due to germline RET gene mutations. The prevalence of these rare diseases their corresponding mutations are unknown the small size study population.We collected data on 250 families hereditary followed in 20 different Italian centres.The most frequent amino acid substitution was Val804Met (19.6%) Cys634Arg (13.6%). A...
Calcitonin (CT) measurement is crucial to the early diagnosis and follow-up of medullary thyroid cancer (MTC). If evaluation stimulated CT levels required, a provocative test can be performed, being high-dose Ca recently reintroduced in clinical practice. Our objective was identify gender-specific thresholds for MTC large series patients who underwent test. A total 91 (49 females 42 males) (calcium gluconate, 25 mg/kg) before thyroidectomy both basal (bCT) (sCT) were compared with...
Multiple endocrine neoplasia type 2A (MEN 2A) and familial medullary thyroid carcinoma (FMTC) are genetic diseases due to activating mutations of the RET proto-oncogene. Affected patients develop (100%), in an isolated form or association with phaeochromocytoma (30-50%), primary hyperparathyroidism (10-20%) 2A). The presence cutaneous lichen amyloidosis (CLA) has been anecdotally described few families harbouring proto-oncogene mutation codon 634. aim study was evaluate incidence CLA MEN...
The evaluation of basal calcitonin (bCT) and stimulated (sCT) can be used for the diagnosis follow-up medullary thyroid cancer (MTC).The aim this study was to evaluate reliability high-calcium (Ca) test identify gender-specific thresholds MTC diagnosis.Patients with in remission (n=24) or persistence (n=18), RET gene mutations carriers (n=14), patients nodular goiter (n=69), healthy volunteers (n=16) were submitted pentagastrin Ca (25 mg/kg) tests.In all groups, levels (CT) by either...
Summary Objective Central hyperthyroidism is mainly due to two different causes, TSH‐secreting pituitary adenoma (TSH‐oma) and resistance thyroid hormone in its variant, i.e. patients presenting with signs symptoms of (PRTH). Because therapeutic approach the clinical follow‐up are extremely these disorders, a correct differential diagnosis mandatory. Unfortunately, no definite pathognomonic tool presently available an extensive biochemical instrumental workup frequently needed order reach...
Primary hyperparathyroidism (PHPT) is a challenging problem in type 1 multiple endocrine neoplasia (MEN1) due to the high postsurgery recurrence rate. The aim was evaluate efficacy of cinacalcet MEN1 patients comparison with sporadic PHPT (sPHPT) and effect Arg990Gly calcium-sensing receptor (CASR) polymorphism on response treatment. This randomized, crossover, double-blind study carried out University Hospitals. Fifteen were randomized two groups, one administered 30 mg daily cinacalcet,...
The coexistence of chronic autoimmune atrophic gastritis (CAAG) and primary hyperparathyroidism (PHPT) has been described previously, even if its extent underlying mechanisms remain poorly understood. We therefore prospectively evaluated this association in two series patients, one with CAAG the other sporadic PHPT.From January 2005 to March 2012, 107 histologically confirmed patients 149 PHPT were consecutively enrolled. Routine laboratory assays included serum calcium, parathyroid hormone...
The cut-off values able to differentiate between reactive or neoplastic C-cell hyperplasia (CCH) predict sporadic medullary thyroid cancer (MTC) are still debated both for basal and stimulated calcitonin (bCT sCT). In the present study, prevalence histological patterns of CCH in 15 patients with multinodular goiter (MNG), bCT>10 pg/ml sCT levels >50 were studied. As controls, 16 MNG bCT <10 4 familial (FMTC) included. For each case, (CT) immunoreactive cells counted 60 consecutive...
The objective of this study was to describe a multiple endocrine neoplasia type 1 (MEN1) family characterized by primary hyperparathyroidism, in association with acromegaly because ectopic growth hormone-releasing hormone (GHRH) secretion pancreatic neuroendocrine tumor young man and bronchial carcinoid his mother. We investigate the clinical, radiological imaging, histopathologic findings, therapy. An 18-year-old successfully underwent subtotal parathyroidectomy for hyperparathyroidism. A...
Hypercalciuria is frequently found in primary hyperparathyroidism (1HPT) and, although it generally normalizes after successful parathyroidectomy, may persist some patients. The factors associated with persistent calcium renal leak (cRL) have not been clarified.The purpose of this study was to determine the prevalence cRL our 1HPT population and investigate cRL-related factors.This a retrospective longitudinal study.The conducted an outpatient setting.The participants were 95 patients...
In patients with neurofibromatosis type 1 (NF1), decreased bone mineral density (BMD) and low levels of 25-hydroxy vitamin D3 (25OHD) have been reported. Recently, the trabecular score (TBS) measurement has proposed as index microarchitecture fracture risk. 74 NF1 (48 females, 26 males, age 41 ± 12), we measured TBS investigated clinical stage, lifestyle, D, serum turnover markers, vertebral femoral BMD. A homogenous cohort 61 healthy subjects was used control group. lower in (1.266 0.113...
Calcitonin (CT) assay is of considerable importance in the routine evaluation thyroid nodules and for screening follow-up patients with medullary carcinoma their relatives. Aim this study was to assess reference ranges CT levels healthy children evaluate possible differences between sex age. Serum were measured by a commercially available two-site chemiluminescence immunometric (sensitivity = 0.2 pg/ml). The ILMA recognizes mature monomeric form CT. We evaluated cohort 125 compared these...
Patients with primary hyperparathyroidism (PHPT) are at risk of chronic kidney disease (CKD). Cystatin C (Cys-C) is considered a more reliable tool to assess glomerular filtration rate (GFR) than creatinine. The study aimed circulating Cys-C and its relationships biochemical PHPT cardiometabolic parameters.The present cross-sectional was performed in academic endocrine units on patients (n=190) non-hypertensive, non-diabetic, age- sex-matched healthy controls (n=135) no established CKD. main...
Summary Objective Ghrelin is a novel gastrointestinal hormone involved in several metabolic functions. It has been identified previously normal and tumoral neuroendocrine tissues, including human medullary thyroid carcinomas (MTCs). The aim of the study was to evaluate ghrelin levels patients with MTC nontoxic goitre (NTG) elevated calcitonin (CT) levels, as an additional marker disease. Patients design included 22 (four before 18 after thyroidectomy), 12 NTG basal CT exceeding 10 ng/l 15...
No studies have carried out an extensive analysis of the possible association between non-syndromic pheochromocytomas and paragangliomas (PPGLs) other malignancies. To assess >the risk additional malignancy in PPGL, we retrospectively evaluated 741 patients with PPGLs followed-up twelve referral centers Italy. Incidence second malignant tumors was compared this cohort Italian two subsequent Among our patients, 95 (12.8%) developed a tumor, which were mainly prostate, colorectal...
Departments of Medical Sciences (M.F., U.V., F.E., P.B.-P., G.M., A.G.L., A.S.) and Obstetrics Gynecology (L.T.), University Milan, 20122 Milan Italy; Endocrinology Diabetology Unit A.S.), Genetics (F.N., F.L.), Neuroradiology (S.A.), Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca’ Granda Ospedale Maggiore Policlinico, Endocrine (A.G.L.), Clinico Humanitas IRCCS, 20089 Rozzano, Italy
The journal and the authors apologise for an error in name of one (appears as Verga Uberta) this article published European Journal Endocrinology Vol 163 301–308 . correct author should be Uberta not published.