A5101816811- Neuroendocrine Tumor Research Advances
- Bone health and treatments
- Parathyroid Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Neuroblastoma Research and Treatments
- Metabolism and Genetic Disorders
- Lung Cancer Research Studies
- Bone health and osteoporosis research
- Genetic Syndromes and Imprinting
- Bone Metabolism and Diseases
- Cancer-related Molecular Pathways
- Vitamin D Research Studies
- Glycogen Storage Diseases and Myoclonus
- Connective tissue disorders research
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Diverse academic and cultural studies
- Dermatological and Skeletal Disorders
- Biochemical and Molecular Research
- Neurological and metabolic disorders
- Heterotopic Ossification and Related Conditions
- Alkaline Phosphatase Research Studies
- Renal Diseases and Glomerulopathies
- Genetic Neurodegenerative Diseases
- Genomic variations and chromosomal abnormalities
Johannes Gutenberg University Mainz
2025
Fondazione FADOI
2023
University of Florence
2013-2022
Società Italiana di Reumatologia
2021
Giuliani (Italy)
2021
Aboca (Italy)
2016
Azienda Ospedaliero-Universitaria Careggi
2004-2014
Universitat Autònoma de Barcelona
2012
Osservatorio astronomico di Bologna
2004-2006
University of Verona
2004-2005
Abstract The molecular mechanisms that regulate hADSC differentiation toward osteogenic precursors and subsequent bone-forming osteoblasts is unknown. Using osteoblast obtained from subcutaneous human adipose tissue, we observed microRNA-26a modulated late by targeting the SMAD1 transcription factor. Introduction: Elucidation of guiding tissue-derived stem cells (hADSCs) extreme importance for improving treatment bone-related diseases such as osteoporosis. aim this study was to identify...
The Italian Society for Orthopaedics and Traumatology conceived this guidance—which is primarily addressed to orthopedic surgeons, but should also prove useful other bone specialists general practitioners—in order improve the diagnosis, prevention, treatment of osteoporosis its consequences. Literature reviews by a multidisciplinary team. following topics are covered: role instrumental, metabolic, genetic evaluations in diagnosis osteoporosis; appraisal risk fracture thresholds intervention;...
Multiple endocrine neoplasia type 1 (MEN1) syndrome is a rare hereditary cancer disorder characterized by tumors of the parathyroids, neuroendocrine cells, gastro-entero-pancreatic tract, anterior pituitary, and non-endocrine neoplasms lesions. MEN1 gene, tumor suppressor encodes menin protein. Loss heterozygosity at 11q13 typical tumors, in agreement with Knudson's two-hit hypothesis. In silico analysis Target Scan, Miranda Pictar-Vert softwares for prediction miRNA targets indicated...
MicroRNAs (miRNAs) are endogenous noncoding RNAs that negatively regulate gene expression by binding the 3' region of messenger RNA targets inducing their cleavage or blocking protein translation. They play important roles in multiple biological and metabolic processes, including developmental timing, signal transduction, cell maintenance differentiation. Their deregulation can predispose to diseases cancer. miRNA has been demonstrated be deregulated many types human tumors, thyroid cancers,...
Ghrelin is a brain-gut peptide with growth hormone-releasing and appetite-inducing activities. A growing body of evidence suggests that ghrelin may affect the central reward system modulate activity mesolimbic system. Recent clinical studies also showed significant positive correlation between plasma levels craving in alcoholics. Accordingly, present study investigated potential role serum reinstatement cocaine-seeking behaviour triggered by cocaine-associated cues. In addition,...
Multiple endocrine neoplasia type 4 (MEN4) is an autosomal dominant disorder that presents with a spectrum of clinical manifestations overlapping those MEN1 syndrome. It caused by inactivating mutations the CDKN1B gene, encoding for p27(kip1) cyclin-dependent kinase 2 inhibitor, implicated in cell cycle control. Eight MEN4 patients have been published so far. The aim this study was to characterize molecular basis case MEN1-like syndrome neuroendocrine tumor and persistent primary...
Abstract PDB is genetically heterogeneous. Mutations of the sequestosome1 gene have been reported in sporadic and familial forms Paget's patients French Canadian British descent. Mutational analyses different ethnic groups are needed to accurately investigate hereditary diseases. We describe two novel mutations 62 Italian patients, confirming role encoded protein this disorder. Introduction: disease bone (PDB) a relatively common metabolism affect up 3% whites over 55 years age. The disorder...
Insulinoma and glucagonoma are two rare functioning neoplasms of the neuroendocrine cells pancreas, respectively, characterized by an uncontrolled over-secretion insulin or glucagon, responsible for development hypoglycemic syndrome syndrome. They prevalently arise as sporadic tumors; only about 10% cases develop in context inherited tumor syndromes, such multiple endocrine neoplasia type 1 (MEN1), neurofibromatosis (NF1), tuberous sclerosis complex (TSC), being result autosomal-dominant...
Background/Objectives: Tumoral calcinosis (TC) is an extremely rare inherited disease characterized by multilobulated, dense ectopic calcified masses, usually in the periarticular soft tissue regions. In a previous study, we isolated primary cell line from lesion of TC patient carrying previously undescribed GALNT3 mutation. Here, researched whether stem (SC) subpopulation, which may play critical role progression, could be present within these lesions. Methods: A putative SC subpopulation...
Polymorphisms of genes encoding enzymes the mevalonate pathway could modulate response to amino-bisphosphonate treatment in postmenopausal osteoporosis.A characterisation 234 Danish osteoporotic women (as part Prospective Epidemiological Risk Factors study (PERF)), treated for at least 2 years with amino-bisphosphonates, respect adenosine/cytosine (A/C) rs2297480 farnesyl pyrophosphate synthase (FDPS) gene polymorphism, was carried out by PCR-based enzymatic digestion and quantitative PCR...