A5073164050- Hemophilia Treatment and Research
- Systemic Sclerosis and Related Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Temporomandibular Joint Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Myeloid Leukemia Treatments
- Shoulder Injury and Treatment
- Dermatologic Treatments and Research
- Bone health and treatments
- Skin Diseases and Diabetes
- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Platelet Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Hip disorders and treatments
- Salivary Gland Disorders and Functions
- Musculoskeletal synovial abnormalities and treatments
- Blood Coagulation and Thrombosis Mechanisms
- Peripheral Nerve Disorders
- Connective tissue disorders research
- Nerve Injury and Rehabilitation
- Autoimmune and Inflammatory Disorders Research
- Shoulder and Clavicle Injuries
University of Florence
2015-2025
Azienda Ospedaliero-Universitaria Careggi
2004-2020
University of Milano-Bicocca
2013
Florence (Netherlands)
2010-2012
Centre for Higher Education
2012
University of Pisa
1996-2005
Ospedale Santa Chiara
1996
Screening for active tuberculosis (TB) and latent TB infection (LTBI) is mandatory prior to the initiation of tumour necrosis factor-alpha inhibitor therapy. However, no agreement exists on best strategy detecting LTBI in this population. The aim present study was analyse performance tuberculin skin test (TST) QuantiFERON-TB Gold in-tube (QFT-GIT) detection subjects with immunomediated inflammatory diseases (IMID). TST QFT-GIT were prospectively performed 398 consecutive IMID subjects, 310...
Summary. Haemarthrosis triggers haemophilic arthropathy (HA) because bleeding starts synovitis immediately, damages cartilage and leads to loss of function disability. The aim our study was investigate the capacity ultrasonography (US) in detecting joint damage HA. joints 62 patients (pts) with haemophilia A or B were consecutively evaluated scored (score ranging from 0 21) for effusion (E), bone remodelling (BR), (CD), synovial hypertrophy (SH), haemosiderin (H), osteophytes (O),...
Abstract Objective The aim of this study was to identify the main CT features that may help in distinguishing a progression interstitial lung disease (ILD) secondary SSc from COVID-19 pneumonia. Methods This multicentric included 22 international readers grouped into radiologist group (RADs) and non-radiologist (nRADs). A total 99 patients, 52 with 47 SSc-ILD, were study. Results Fibrosis inside focal ground-glass opacities (GGOs) upper lobes; fibrosis lower lobe GGOs; reticulations lobes...
Objective. To identify the clinical features that can help to distinguish between psoriatic arthritis (PsA) and fibromyalgia (FM). Methods. Our cross-sectional study was carried out in 10 Italian rheumatology centers January September 2009, enrolled all consecutive patients with PsA FM who agreed participate. Standard laboratory data for were collected from patients. Records made of somatic symptoms, response nonsteroidal antiinflammatory drugs (NSAID), self-evaluated pain, general health,...
In systemic sclerosis (SSc), joint involvement may reduce the functional capacity of hands. Intravenous immunoglobulins have previously been shown to benefit patients with SSc.To verify efficacy intravenous on and function in SSc.7 women SSc, 5 limited 2 diffuse a severe refractory were enrolled study. Methotrexate cyclophosphamide pulse therapy did not ameliorate symptoms. Hence, was prescribed at dosage g/kg body weight during 4 days/month for six consecutive courses. The presence...
Recent evidence suggests that patients with severe hemophilia B may have a less disease compared to A. To investigate clinical, radiological, laboratory and histological differences in the arthropathy of A B, 70 35 at least one joint bleeding were consecutively enrolled. Joint bleedings (50), regimen treatment (prophylaxis/on demand), World Federation Hemophilia, Pettersson ultrasound scores, serum soluble RANK ligand osteoprotegerin assessed all patients. RANK, expression was evaluated...
Abstract Objectives We characterized the microbiota in SSc, focusing on skin–oral–gut axis and serum faecal free fatty acid (FFA) profile. Methods Twenty-five SSc patients with ACA or anti-Scl70 autoantibodies were enrolled. The of faecal, saliva superficial epidermal samples was assessed through next-generation sequencing analysis. GC-MS used to quantify FFAs. Gastrointestinal symptoms investigated University California Los Angeles Scleroderma Clinical Trial Consortium Tract Instrument...
Abstract PDB is genetically heterogeneous. Mutations of the sequestosome1 gene have been reported in sporadic and familial forms Paget's patients French Canadian British descent. Mutational analyses different ethnic groups are needed to accurately investigate hereditary diseases. We describe two novel mutations 62 Italian patients, confirming role encoded protein this disorder. Introduction: disease bone (PDB) a relatively common metabolism affect up 3% whites over 55 years age. The disorder...
Objective. To define the diagnostic value of ultrasonographic (US) examination in comparison with magnetic resonance imaging (MRI) for assessment temporomandibular joint (TMJ) involvement rheumatoid arthritis (RA) and psoriatic (PsA).
Hemarthrosis triggers hemophilic arthropathy, involving the target joints. The histopathogenesis of blood-induced joint damage remains unclear. triad receptor activator nuclear factor-κB (RANK), RANK ligand (RANKL), and osteoprotegerin (OPG; RANK-RANKL-OPG) controls bone turnover. Our aim was to evaluate RANK-RANKL-OPG expression in synovium patients with severe arthropathy.Synovial biopsies were obtained from 18 arthropathy 16 osteoarthritis (OA) who undergoing total knee replacement...
Abstract Background Repeated intra‐articular bleedings in patients with haemophilia results a crippling arthropathy for which no specific treatment is currently available. Recent studies have shown that neoangiogenesis involved the pathologic process. The aim of this study was to determine whether angiogenesis dysregulated haemophilic joint disease ( HJD ). Methods Synovial tissue and synovial fluid were collected from severe undergoing knee or hip replacement control group consisting...
summary The aim of this work was to evaluate the accuracy and reliability ultrasonography in diagnosis temporomandibular joint (TMJ) disc position abnormalities compared with magnetic resonance imaging (MRI). Participants study were 41 consecutive patients signs symptoms disorders. All 82 TMJs evaluated detect by means MRI, performed blinded operators. respect MRI. Ultrasonography demonstrated good evaluation position, showing a sensitivity 65·8% specificity 80·4%, resulting positive...
Objective. Systemic sclerosis (SSc) is characterized by microvascular and macrovascular alterations. The D allele of the ACE I/D polymorphism known to be associated with an increased incidence atherosclerosis has been recently proposed as risk SSc. This study evaluates relationship between intima-media thickness (IMT), ankle-brachial pressure measurements (ABPI) in SSc patients. Methods. According presence (analysed PCR), 53 patients (47 females 6 males; median age was 60.4 ± 10.68 yrs;...
The aim of this study was to evaluate whether an increased capsular width evidenced by ultrasound (US) could be indirect marker temporomandibular joint (TMJ) effusion.138 TMJs were evaluated US and magnetic resonance imaging (MRI) two blinded calibrated investigators. measures (in mm) MRI diagnosis TMJ effusion (presence/absence) used perform a receiver operating characteristic (ROC) curve analysis in order assess the most accurate cut-off value that able discriminate between joints with...
In the present study we investigated predictive value of anti-cyclic citrullinated peptide antibodies (anti-CCP) in early rheumatoid arthritis (RA) with respect to bone damage.Fifty-four patients RA (onset <12 months), 35 classified as established >12 33 healthy donors and 76 non-RA autoimmune diseases, were enrolled. Anti-CCP IgG, IgA, IgM factors (RFs) determined at baseline. Disease activity score (DAS 28) was calculated entry. Bone involvement evaluated by X-rays sonography.The...
Objective. To compare clinical and X-ray examinations with US findings of SI joints (SIJ) in early SpA patients. Methods. Twenty-three patients, diagnosed according to Assessment SpondyloArthritis international Society criteria, were investigated clinically [sacral sulcus tenderness, BASMI, BASFI, BASDAI, pain fatigue visual analogue scale (VAS), morning stiffness sleep disturbance], SIJ X-rays (New York score) My Lab70 7–10 MHz (Esaote, Genoa, Italy), evaluating the width capsule posterior...
Recent reports show a correlation between haemophilia and osteoporosis. HIV, HCV their treatments are independently associated with an increased risk of Vitamin D plays pivotal role in bone mineralization. The aim our study was to compare levels, metabolism markers mineral density (BMD) patients or without co-infections. Seventy-eight adult severe moderate A B were subdivided into three groups 26 each (HIV-HCV co-infected, mono-infected uninfected). BMD measured by dual energy X-ray...